Catalog No.
RHH29002
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Dihydropyrimidinase-related protein 2, N2A3, CRMP-2, DPYSL2, ULIP-2, ULIP2, Collapsin response mediator protein 2, Unc-33-like phosphoprotein 2, CRMP2, DRP-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16555
Applications
FCM, IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2H07
CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation, and arthritic pain., PMID:40258133
Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline., PMID:39719537
Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline., PMID:39606475
Anti-CRMP2 antibody induces anxiety-like behavior and increases pyramidal neuron excitability in mice., PMID:38986818
CRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway., PMID:35927239
Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability., PMID:35618885
Identification of Anti-Collapsin Response Mediator Protein 2 Antibodies in Patients With Encephalitis or Encephalomyelitis., PMID:35479088
Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism., PMID:33483694
Can Maternal Autoantibodies Play an Etiological Role in ASD Development?, PMID:32581542
Peptides of neuron specific enolase as potential ASD biomarkers: From discovery to epitope mapping., PMID:31812776
Inhibition of Ubc9-Induced CRMP2 SUMOylation Disrupts Glioblastoma Cell Proliferation., PMID:31267313
Label-free and spectral-analysis-free detection of neuropsychiatric disease biomarkers using an ion-sensitive GaInAsP nanolaser biosensor., PMID:29894853
Increased Levels of Circulating Glial Fibrillary Acidic Protein and Collapsin Response Mediator Protein-2 Autoantibodies in the Acute Stage of Spinal Cord Injury Predict the Subsequent Development of Neuropathic Pain., PMID:29774780
Toll‑Like receptor 4 promotes the phosphorylation of CRMP2 via the activation of Rho‑kinase in MCAO rats., PMID:29749502
Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway., PMID:29238028
Interaction of Recombinant Gallus gallus SEPT5 and Brain Proteins of H5N1-Avian Influenza Virus-Infected Chickens., PMID:28895884
Antisera against Neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species., PMID:27765579
Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice., PMID:27423553
Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex., PMID:27324898
Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2., PMID:26804001
Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis., PMID:26555036
Expression of neuronal and signaling proteins in penumbra around a photothrombotic infarction core in rat cerebral cortex., PMID:26531025
Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis., PMID:26481340
Tax and Semaphorin 4D Released from Lymphocytes Infected with Human Lymphotropic Virus Type 1 and Their Effect on Neurite Growth., PMID:26389656
Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis., PMID:25721514
Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity., PMID:24474686
Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent., PMID:24224061
Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy., PMID:24066722
Autism-specific maternal autoantibodies recognize critical proteins in developing brain., PMID:23838888
Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC., PMID:23023514
ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA., PMID:22558255
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation., PMID:22544872
Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress., PMID:22443207
Proteomic analyses of lung lysates from short-term exposure of Fischer 344 rats to cigarette smoke., PMID:21627322
The memory enhancing effect of the APP-derived tripeptide Ac-rER is mediated through CRMP2., PMID:21255016
First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia., PMID:20573273
Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32., PMID:19652227
Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine., PMID:19457111
Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis., PMID:19405105
Calpain-mediated cleavage of collapsin response mediator protein(CRMP)-2 during neurite degeneration in mice., PMID:18052987
High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation., PMID:18006081
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression., PMID:17683481
Proteomic identification of a novel isoform of collapsin response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia., PMID:17051644
[Molecular mechanism of axon guidance]., PMID:16866215
Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism., PMID:16595691
Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain., PMID:15834957
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease., PMID:15676027
Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons., PMID:15033171
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology., PMID:12482610
Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes., PMID:11549731
For research use only. Not for human or drug use.
