Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Antibody / Recombinant Antibody

Anti-RPE65 Antibody (R2G92)

Catalog #:   RHH27401 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IP, WB
Accession: Q16518
Overview

Catalog No.

RHH27401

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IP: 1:20-1:50, WB: 1:1000-1:2000

Target

Retinoid isomerohydrolase, Retinol isomerase, Retinal pigment epithelium-specific 65 kDa protein, RPE65, Lutein isomerase, Meso-zeaxanthin isomerase, All-trans-retinyl-palmitate hydrolase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q16518

Applications

IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2G92

Data Image
  • Western blot
    Western blot analysis of RPE65 expression in mouse eyeball lysate.
  • Western blot
    All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
References

Genetic mutation in HSF4 is associated with retinal degeneration in mice., PMID:40023307

Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles., PMID:38892233

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium., PMID:34448806

Effect of Long-term Anti-VEGF Treatment on Viability and Function of RPE Cells., PMID:33998943

Immune responses to retinal gene therapy using adeno-associated viral vectors - Implications for treatment success and safety., PMID:33069860

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration., PMID:33027920

Palmitoylation of Metazoan Carotenoid Oxygenases., PMID:32331396

Safety of Same-Eye Subretinal Sequential Readministration of AAV2-hRPE65v2 in Non-human Primates., PMID:31660416

Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy., PMID:31580392

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium., PMID:31245172

Effects of Ranibizumab, Bevacizumab, and Aflibercept on Senescent Retinal Pigment Epithelial Cells., PMID:30091312

Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice., PMID:29874126

Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy., PMID:29774302

Antigen-specificity of antiretinal antibodies in patients with noninfectious uveitis., PMID:28985805

The effects of platelet gel on cultured human retinal pigment epithelial (hRPE) cells., PMID:28632489

Association of Circulating Markers With Outcome Parameters in the Bevacizumab and Ranibizumab in Diabetic Macular Edema Trial., PMID:27842163

Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice., PMID:27537685

Time-Dependent Changes of Cell Proliferation After Laser Photocoagulation in Mouse Chorioretinal Tissue., PMID:25813995

Histopathology of the Retina from a Three Year-Old Suspected to Have Joubert Syndrome., PMID:27747301

Protection of cone photoreceptor M-opsin degradation with 9-cis-β-carotene-rich alga Dunaliella bardawil in Rpe65(-/-) mouse retinal explant culture., PMID:25006880

Update on current and future novel therapies for dry age-related macular degeneration., PMID:23971874

Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer., PMID:23833067

Bioactive substrates for human retinal pigment epithelial cell growth from elastin-like recombinamers., PMID:23554132

Histology and immunochemistry evaluation of autologous translocation of retinal pigment epithelium-choroid graft in porcine eyes., PMID:23256869

Differential proteomics and functional research following gene therapy in a mouse model of Leber congenital amaurosis., PMID:22953002

The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina., PMID:22845794

Early apoptosis of rod photoreceptors in Rpe65(-/-) mice is associated with the upregulated expression of lysosomal-mediated autophagic genes., PMID:22227450

Histopathology and functional correlations in a patient with a mutation in RPE65, the gene for retinol isomerase., PMID:21931134

Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19., PMID:21743014

An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species., PMID:21676174

The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65., PMID:21493626

Elastin-like recombinamers as substrates for retinal pigment epithelial cell growth., PMID:21442725

Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis., PMID:21169527

Gene therapy in the second eye of RPE65-deficient dogs improves retinal function., PMID:20703309

Altered expression of retinal molecular markers in the canine RPE65 model of Leber congenital amaurosis., PMID:20671290

Quantification of retinal pigment epithelial phenotypic variation using laser scanning cytometry., PMID:20606706

Effective and sustained delivery of hydrophobic retinoids to photoreceptors., PMID:20574023

Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness., PMID:20374996

Importance of membrane structural integrity for RPE65 retinoid isomerization activity., PMID:20100834

A battery of cell- and structure-specific markers for the adult porcine retina., PMID:20086234

Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice., PMID:20053900

Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration., PMID:19953081

In vivo analysis of cone survival in mice., PMID:19737879

Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year., PMID:19583479

The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins., PMID:19458327

Isolation and characterization of a spontaneously immortalized bovine retinal pigmented epithelial cell line., PMID:19413901

Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement., PMID:19407011

Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice., PMID:19340848

Bacillus cereus-induced permeability of the blood-ocular barrier during experimental endophthalmitis., PMID:19264886

Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye., PMID:19190735

Datasheet

Document Download

Anti-RPE65 Antibody (R2G92).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Anti-RPE65 Antibody (R2G92) [RHH27401]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only