Catalog No.
RHG61402
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Cullin-3, KIAA0617, CUL-3, CUL3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13618
Applications
FCM, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2E80
Whole-genome CRISPR screening identifies molecular mechanisms of PD-L1 expression in adult T-cell leukemia/lymphoma., PMID:38142436
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation., PMID:37881876
Activity-based profiling of cullin-RING E3 networks by conformation-specific probes., PMID:37653169
Mitochondrial Dysfunction and Impaired Antioxidant Responses in Retinal Pigment Epithelial Cells Derived from a Patient with RCBTB1-Associated Retinopathy., PMID:37408192
Activity-based profiling of cullin-RING ligase networks by conformation-specific probes., PMID:36711970
NCC regulation by WNK signal cascade., PMID:36685207
Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function., PMID:36196997
Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function., PMID:35385574
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice., PMID:34803491
Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells., PMID:34063559
Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells., PMID:32341059
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis., PMID:30872636
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex., PMID:27706223
Regulation of the MEI-1/MEI-2 Microtubule-Severing Katanin Complex in Early Caenorhabditis elegans Development., PMID:27527792
Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma., PMID:27488521
Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3., PMID:26435498
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution., PMID:25790038
The E3 ligase CUL3/RDX controls centromere maintenance by ubiquitylating and stabilizing CENP-A in a CAL1-dependent manner., PMID:24636256
Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy., PMID:22836768
Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons., PMID:21710140
Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation., PMID:20864537
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation., PMID:20154143
TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm., PMID:19930467
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes., PMID:19617556
Regulation of RhoBTB2 by the Cul3 ubiquitin ligase complex., PMID:18374159
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2., PMID:17636022
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation., PMID:16547521
Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis., PMID:16162871
In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3., PMID:11311237
For research use only. Not for human or drug use.
