Catalog No.
RHG57501
Species reactivity
Human, Mouse, Rat, Hamster
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13526
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2E51
OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth., PMID:39862868
Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia., PMID:39857613
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis., PMID:39724988
Investigation of the expression of Cis P-tau and Pin1 proteins following air pollution induction in the brain tissue of C57BL/6 mice., PMID:39192599
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery., PMID:38889227
Allergic inflammation triggers dyslipidemia via IgG signalling., PMID:38864116
Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation., PMID:38727267
Identification of Individual Target Molecules Using Antibody-Decorated DeepTipTM Atomic-Force Microscopy Probes., PMID:38667203
The role of the Pin1-cis P-tau axis in the development and treatment of vascular contribution to cognitive impairment and dementia and preeclampsia., PMID:38628595
Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting., PMID:38299128
Prolyl isomerase Pin1 sculpts the immune microenvironment of colorectal cancer., PMID:38199598
Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia., PMID:37669931
Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies., PMID:37638382
Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines., PMID:37240193
Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer., PMID:36252998
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype., PMID:36223740
Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement., PMID:35879297
Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis., PMID:35796272
Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela., PMID:35501632
Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP., PMID:35235182
Phase II Single-Arm Study to Assess Trastuzumab and Vinorelbine in Advanced Breast Cancer Patients With HER2-Negative Tumors and HER2-Positive Circulating Tumor Cells., PMID:34994617
Distinct phosphorylation profiles of tau in brains of patients with different tauopathies., PMID:34536819
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy., PMID:34388391
Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice., PMID:34078745
Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury., PMID:33979671
A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma., PMID:33067267
Effect of Eribulin With or Without Pembrolizumab on Progression-Free Survival for Patients With Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer: A Randomized Clinical Trial., PMID:32880602
Tau Pathology Triggered by Spinal Cord Injury Can Play a Critical Role in the Neurotrauma Development., PMID:32808121
Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases., PMID:30197831
Okadaic acid-induced tau hyperphosphorylation and the downregulation of Pin1 expression in primary cortical neurons., PMID:29860071
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation., PMID:29686383
Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells., PMID:29603395
Regulation of asymmetric polar auxin transport by PsPIN1 in endodermal tissues of etiolated Pisum sativum epicotyls: focus on immunohistochemical analyses., PMID:29589195
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae., PMID:29042562
Immunofluorescence Analysis of Membrane-Associated Proteins for Clathrin-Mediated Endocytosis in Plant Root Cells., PMID:28861825
Involvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells., PMID:28214206
Dynamic PIN-FORMED auxin efflux carrier phosphorylation at the plasma membrane controls auxin efflux-dependent growth., PMID:28096328
Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration., PMID:27980715
Phosphorylation mechanisms in dopamine transporter regulation., PMID:27836487
Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells., PMID:27770268
Potential of the Antibody Against cis-Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury., PMID:27654282
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress., PMID:27556400
Deciphering transcriptome profiles of peripheral blood mononuclear cells in response to PRRSV vaccination in pigs., PMID:27528396
PIN1 Suppresses the Hepatic Differentiation of Pulp Stem Cells via Wnt3a., PMID:27439725
Protein Interacting with Never in Mitosis A-1 Induces Glutamatergic and GABAergic Neuronal Differentiation in Human Dental Pulp Stem Cells., PMID:27178251
Pin1-Targeted Therapy for Systemic Lupus Erythematosus., PMID:27159270
Phosphoproteomic Analysis Using the WW and FHA Domains as Biological Filters., PMID:26119529
Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease., PMID:25583562
Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease., PMID:25576397
Role of auxin during intercellular infection of Discaria trinervis by Frankia., PMID:25191330
For research use only. Not for human or drug use.
