Catalog No.
RHG55601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:500-1:1000
Target
TNFR2-TRAF-signaling complex protein 2, API1, hIAP2, BIRC2, C-IAP1, Inhibitor of apoptosis protein 2, hIAP-2, MIHB, RING finger protein 48, RNF48, Cellular inhibitor of apoptosis 1, RING-type E3 ubiquitin transferase BIRC2, Baculoviral IAP repeat-containing protein 2, IAP homolog B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13490
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2E44
Chimeric antigen receptor dendritic cells targeted delivery of a single tumoricidal factor for cancer immunotherapy., PMID:39105847
An 8-aminoquinoline-naphthyl copper complex causes apoptotic cell death by modulating the expression of apoptotic regulatory proteins in breast cancer cells., PMID:38908670
Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles., PMID:38596136
Targeting the TNF/IAP pathway synergizes with anti-CD3 immunotherapy in T-cell acute lymphoblastic leukemia., PMID:38437728
CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects., PMID:37595047
The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy., PMID:37304285
Identification of cerebrospinal fluid biomarker candidates for anti-N-methyl-D-aspartate receptor encephalitis: High-throughput proteomic investigation., PMID:36389787
Inhibitor of apoptosis proteins antagonist SM164 ameliorates experimental MPO-ANCA-associated vasculitis via enhancing fatty acid oxidation in neutrophils., PMID:36308438
Kaempferol sensitizes tumor necrosis factor-related apoptosis-inducing ligand-resistance chronic myelogenous leukemia cells to apoptosis., PMID:34820749
BET Inhibition Enhances TNF-Mediated Antitumor Immunity., PMID:34782346
Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death., PMID:34634376
Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant., PMID:33257690
Galectin-3 mediates survival and apoptosis pathways during Trypanosoma cruzi-host cell interplay., PMID:32535113
The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein., PMID:32290047
Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection., PMID:32234472
Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis., PMID:31885495
Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways., PMID:31831875
Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells., PMID:31581454
Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy., PMID:31266830
Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner., PMID:30036391
Nimbolide induced apoptosis by activating ERK-mediated inhibition of c-IAP1 expression in human hepatocellular carcinoma cells., PMID:29962003
Regulation of innate and adaptive antitumor immunity by IAP antagonists., PMID:29807457
A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity., PMID:29679556
Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells., PMID:29663486
Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α., PMID:29152118
Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)., PMID:28424988
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease., PMID:27503909
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma., PMID:27070702
Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells., PMID:26944210
PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy., PMID:26799286
Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets., PMID:26608647
Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells., PMID:26575016
The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis., PMID:26383618
Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia., PMID:26096065
CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes., PMID:25493017
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions., PMID:25476903
Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma., PMID:25344582
Pro-apoptotic effect of an anti-CD37 scFv-Fc fusion protein, in combination with the anti-CD20 antibody, ofatumumab, on tumour cells from B-cell malignancies., PMID:25154027
Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly., PMID:24855207
cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation., PMID:24276241
Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis., PMID:24184825
Smac mimetic compound LCL161 sensitizes esophageal carcinoma cells to radiotherapy by inhibiting the expression of inhibitor of apoptosis protein., PMID:24170321
Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer., PMID:24104966
Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain., PMID:24083782
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells., PMID:23269627
Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism., PMID:23225169
Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma., PMID:23029050
Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation., PMID:22519592
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner., PMID:22469979
Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma., PMID:22198862
For research use only. Not for human or drug use.
