Catalog No.
YHC87501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys174-Asp331
Predicted molecular weight
19.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11274
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Renal carcinoma antigen NY-REN-26, BCR1, BCR, D22S11, Breakpoint cluster region protein
Validation of a novel NGS based BCR::ABL1 kinase domain mutation detection assay in Indian cohort., PMID:38977756
Glioblastoma, IDH-Wildtype With Epithelioid Morphology and a BCR::NTRK2 Fusion., PMID:38562049
Emergence of a BCR::ABL1 rearrangement following a uniquely complex clonal evolution pattern in a patient undergoing Fms-like tyrosine kinase 3 inhibitor therapy for acute myeloid leukemia., PMID:36180046
LncRNA FIRRE stimulates PTBP1-induced Smurf2 decay, stabilizes B-cell receptor, and promotes the development of diffuse large B-cell lymphoma., PMID:35416325
Identification of putative genetic variants in major depressive disorder patients in Pakistan., PMID:35040003
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3., PMID:34941574
A rare case of atypical chronic myeloid leukemia associated with t(8;22)(p11.2;q11.2)/ BCR-FGFR1 rearrangement: A case report and literature review., PMID:34551378
A case of a patient characterized by t(8;22)(p11;q11) and BCR/FGFR1 fusion gene, who was successfully treated with haploidentical hematopoietic stem cell transplantation., PMID:34493159
Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis., PMID:34292334
Loss function of Bcr mutation causes gastrointestinal dysmotility and brain developmental defects., PMID:34190380
Genomics of Resistance to Targeted Therapies., PMID:34174982
Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway., PMID:34109977
Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL., PMID:33895809
CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation., PMID:33879857
Mutation Profile in BCR-ABL1-Negative Myeloproliferative Neoplasms: A Single-Center Experience From India., PMID:33789164
Nuclear localization of BCR and cortactin indicates their potential role in regulation of actin branching in nucleus., PMID:33785719
BCR-NTRK2 fusion in a pediatric patient with spinal gangliocytoma., PMID:33773051
BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation., PMID:33534893
Identification of "regulation of RhoA activity panel" as a prognostic and predictive biomarker for gastric cancer., PMID:33288739
miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors., PMID:33171493
Integrated genomic analysis using chromosomal microarray, fluorescence in situ hybridization and mate pair analyses: Characterization of a cryptic t(9;22)(p24.1;q11.2)/BCR-JAK2 in myeloid/lymphoid neoplasm with eosinophilia., PMID:32827877
Scaffold hopping of the SYK inhibitor entospletinib leads to broader targeting of the BCR signalosome., PMID:32731189
Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors., PMID:32659728
Spectrum of gene mutations identified by targeted next-generation sequencing in Chinese leukemia patients., PMID:32638549
The adaptor protein APS modulates BCR signalling in mature B cells., PMID:32470518
CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Bcr-Abl-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways., PMID:32276588
Prognostic Significance of bcr-1 and bcr-3 Isoforms of PML-RARA and FLT3-ITD in Patients With Acute Promyelocytic Leukemia., PMID:32033928
Functional characterization of two rare BCR-FGFR1+ leukemias., PMID:31980503
CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition., PMID:31974435
Myeloid neoplasm with eosinophilia and BCR-JAK2/t(9;22)(p24;q11.2) morphologically mimicking chronic myeloid leukemia., PMID:31865248
Repurposing Drugs by In Silico Methods to Target BCR Kinase Domain in Chronic Myeloid Leukemia., PMID:31759365
Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak., PMID:31707540
Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome., PMID:31525277
Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3., PMID:31472403
The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest., PMID:31461398
Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation., PMID:31439673
B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota., PMID:31433298
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections., PMID:31433296
Chronic Myeloid Leukemia as Secondary Malignancy Following the Treatment of Hodgkin Lymphoma: A Case Series., PMID:31366526
Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia., PMID:31230372
SETD2, GIGYF2, FGFR3, BCR, KMT2C, and TSC2 as candidate genes for differentiating multilocular cystic renal neoplasm of low malignant potential from clear cell renal cell carcinoma with cystic change., PMID:31098421
BCR-ABL1-like B-Lymphoblastic Leukemia/Lymphoma with FOXP1-ABL1 Rearrangement: Comprehensive Laboratory Identification Allowing Tyrosine Kinase Inhibitor Use., PMID:30938769
BCR-NTRK2 fusion in a low-grade glioma with distinctive morphology and unexpected aggressive behavior., PMID:30936198
Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice., PMID:30413411
Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation., PMID:30336225
Allogeneic hematopoietic stem cell transplantation for 8p11 myeloproliferative syndrome with BCR-FGFR1 gene rearrangement: a case report and literature review., PMID:30087462
Evolving treatment strategies in CML - moving from early and deep molecular responses to TKI discontinuation and treatment-free remission: is there a need for longer-term trial outcomes?, PMID:29862545
Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma., PMID:29549872
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation., PMID:29514960
RETRACTED: Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K., PMID:29501569
For research use only. Not for human or drug use.
