Catalog No.
RHF85301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
Retinoblastoma-binding protein 3, Retinoblastoma-associated protein 1, RBBP-3, Transcription factor E2F1, RBBP3, E2F1, E2F-1, RBAP-1, pRB-binding protein E2F-1, PBR3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q01094
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2B86
Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656
Unveiling the Molecular Mechanism of Trastuzumab Resistance in SKBR3 and BT474 Cell Lines for HER2 Positive Breast Cancer., PMID:38534787
TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma., PMID:38030304
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4., PMID:37198697
Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels., PMID:36358737
Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer., PMID:35289120
Translational control of E2f1 regulates the Drosophila cell cycle., PMID:35074910
Relationship between IGF-1 and body weight in inflammatory bowel diseases: Cellular and molecular mechanisms involved., PMID:34601192
Anti-Proliferative Effects of E2F1 Suppression in Glioblastoma Cells., PMID:34482308
LMCD1 antisense RNA 1 is a newly identified long noncoding RNA., PMID:34232945
In search for biomarkers and potential drug targets for uterine serous endometrial cancer., PMID:33754208
Regulation of E2F1 activity via PKA-mediated phosphorylations., PMID:33110360
RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis., PMID:33014855
Downregulation of SRPK2 promotes cell cycle arrest though E2F1 in non-small cell lung cancer., PMID:31833327
PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease., PMID:31748600
Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia., PMID:31066008
NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation., PMID:31043075
Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR., PMID:30958852
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab., PMID:30647455
Inhibition of microRNA-299-5p sensitizes glioblastoma cells to temozolomide via the MAPK/ERK signaling pathway., PMID:30061180
Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells., PMID:29969371
Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody., PMID:29955626
Arsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells., PMID:28420331
KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1., PMID:27780824
Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex., PMID:27771897
CADM1 regulates the G1/S transition and represses tumorigenicity through the Rb-E2F pathway in hepatocellular carcinoma., PMID:27298105
Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma., PMID:26722215
V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy., PMID:26356814
A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting [corrected]., PMID:26242403
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer., PMID:26178168
E2F8 as a Novel Therapeutic Target for Lung Cancer., PMID:26089541
Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy., PMID:25714011
Exploring the genes associated with the response to intravenous immunoglobulin in patients with Kawasaki disease using DNA microarray analysis., PMID:25449331
E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression., PMID:25341896
E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation., PMID:25341426
ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction., PMID:25246633
Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin., PMID:25042645
Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis., PMID:24901013
Transcription of the Geminin gene is regulated by a negative-feedback loop., PMID:24554762
Distinct and site-specific phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells., PMID:24466208
Loss of dE2F compromises mitochondrial function., PMID:24286825
MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module., PMID:24136167
The E2F1/DNMT1 axis is associated with the development of AR negative castration resistant prostate cancer., PMID:24038143
E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B., PMID:24014887
The monoclonal antibody CH12 augments 5-fluorouracil-induced growth suppression of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III., PMID:24007863
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function., PMID:23966291
Dynamic changes in the initial colonization of Actinomyces naeslundii and Streptococcus gordonii using a new animal model., PMID:23429078
Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development., PMID:23407946
Antiproliferative activity of Alpinia officinarum extract in the human breast cancer cell line MCF-7., PMID:23404367
Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization., PMID:23226476
For research use only. Not for human or drug use.
