Catalog No.
RHE35401
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
RAFT1, Rapamycin target protein 1, Mechanistic target of rapamycin, FRAP, FKBP12-rapamycin complex-associated protein, mTOR, FRAP1, FK506-binding protein 12-rapamycin complex-associated protein 1, Rapamycin and FKBP12 target 1, FRAP2, RAPT1, Serine/threonine-protein kinase mTOR, Mammalian target of rapamycin, MTOR
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P42345
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1W17
Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study., PMID:40352587
Impaired Autophagy Induced by oxLDL/β2GPI/anti-β2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction., PMID:34221236
The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair., PMID:32368441
Yokukansan, a Kampo medicine, enhances the level of neuronal lineage markers in differentiated P19 embryonic carcinoma cells., PMID:31692643
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors., PMID:30894200
CD71+VISTA+ erythroid cells promote the development and function of regulatory T cells through TGF-β., PMID:30550561
Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia., PMID:30278995
Long-term treatment with anti-VEGF does not induce cell aging in primary retinal pigment epithelium., PMID:29522724
EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas., PMID:29278885
A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway., PMID:28442920
Impact of mTOR expression on clinical outcome in paediatric patients with B-cell acute lymphoblastic leukaemia - preliminary report., PMID:27688725
CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways., PMID:27391150
MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer., PMID:27184134
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors., PMID:26771843
Expression of Mammalian Target of Rapamycin and Downstream Targets in Normal and Gestational Diabetic Human Term Placenta., PMID:26335179
Methods to identify molecular expression of mTOR pathway: a rationale approach to stratify patients affected by clear cell renal cell carcinoma for more likely response to mTOR inhibitors., PMID:25520878
AKT/mTOR and c-Jun N-terminal kinase signaling pathways are required for chrysotile asbestos-induced autophagy., PMID:24735948
Intracellular signaling pathways and size, shape, and rupture history of human intracranial aneurysms., PMID:22278358
Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma., PMID:21543427
Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein., PMID:21424608
Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours., PMID:21290341
The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases., PMID:20830770
Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling., PMID:20603172
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis., PMID:16884363
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth., PMID:15208673
For research use only. Not for human or drug use.
