Catalog No.
RHD30602
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
CHC1, RCC1, Chromosome condensation protein 1, Regulator of chromosome condensation, Cell cycle regulatory protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P18754
Applications
FCM, IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1Q93
Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch., PMID:39149911
Antinuclear antibodies in individuals with COVID-19 reflect underlying disease: Identification of new autoantibodies in systemic sclerosis (CDK9) and malignancy (RNF20, RCC1, TRIP13)., PMID:36738952
Identification of new telomere- and telomerase-associated autoantigens in systemic sclerosis., PMID:36634459
The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif11; SuURES Su(var)3-906 Mutations Suppressing Underreplication., PMID:34831030
Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27kip1 /CDK4 axis in non-small cell lung cancer., PMID:33630417
Somatic Mutations in NEK9 Cause Nevus Comedonicus., PMID:27153399
The MRN-CtIP pathway is required for metaphase chromosome alignment., PMID:23434370
CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling., PMID:23228632
Xtr, a plural tudor domain-containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis., PMID:22889276
Modulation of CD4+ T-cell activation by CD95 co-stimulation., PMID:21052094
Relative contributions of chromatin and kinetochores to mitotic spindle assembly., PMID:19805628
Xtr, a plural tudor domain-containing protein, coexists with FRGY2 both in cytoplasmic mRNP particle and germ plasm in Xenopus embryo: its possible role in translational regulation of maternal mRNAs., PMID:21314676
Perturbation of the chromosomal binding of RCC1, Mad2 and survivin causes spindle assembly defects and mitotic catastrophe., PMID:18712773
Adjuvant effects of bacillus Calmette-Guerin DNA or CpG-oligonucleotide in the immune response to Taenia solium cysticercosis vaccine in porcine., PMID:18021362
Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus., PMID:17971412
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies., PMID:17904189
Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase., PMID:17443675
Developmental and tissue expression of Xenopus laevis RPGR., PMID:16384984
RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins., PMID:16043481
Proteomic analysis of mantle-cell lymphoma by protein microarray., PMID:15650054
Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly., PMID:12494999
Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus., PMID:12456727
Complex expression pattern of RPGR reveals a role for purine-rich exonic splicing enhancers., PMID:12407146
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression., PMID:12101123
Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system., PMID:11231159
HERC3 binding to and regulation by ubiquitin., PMID:11163799
GTP hydrolysis by Ran is required for nuclear envelope assembly., PMID:10911995
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression., PMID:10850413
Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran., PMID:10679025
DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness., PMID:10571079
Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts., PMID:10381400
Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate., PMID:9817595
An RCC1-type guanidine exchange factor for the Ran G protein is found in the Plasmodium falciparum nucleus., PMID:9763300
Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr)., PMID:9677393
Inhibition by anti-RCC1 monoclonal antibodies of RCC1-stimulated guanine nucleotide exchange on Ran GTPase., PMID:9498556
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway., PMID:9394008
The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport., PMID:9348536
Direct and indirect association of the small GTPase ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts., PMID:8885229
A giant nucleopore protein that binds Ran/TC4., PMID:7603572
The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1., PMID:7782302
Isolation of human NuMA protein., PMID:7957946
Preliminary findings of chromosomal alterations and expression of cell cycle genes in head an neck tumors., PMID:11894785
NuMA is required for the proper completion of mitosis., PMID:8432734
Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis., PMID:8421051
Nuclear PRP20 protein is required for mRNA export., PMID:7679070
Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm., PMID:1337289
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide., PMID:1961752
Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1., PMID:1944575
Analysis of yeast prp20 mutations and functional complementation by the human homologue RCC1, a protein involved in the control of chromosome condensation., PMID:1865879
The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1., PMID:2022188
For research use only. Not for human or drug use.
