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Anti-IRF1 Antibody (R1N19)

Catalog #:   RHC84402 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, IHC, IP, WB
Accession: P10914
Overview

Catalog No.

RHC84402

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000

Target

Interferon regulatory factor 1, IRF-1, IRF1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P10914

Applications

IF, IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1N19

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of IRF1 (green) in U87-MG using IRF1 antibody,and DAPI(blue).
  • Immunohistochemical
    Immunohistochemistry analysis of paraffin-embedded Human lung cancer tissue using IRF1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Western blot
    Western blot analysis of IRF1 in K562, C6, 3T3 lysates using IRF1 antibody.
References

Expression of Immune-Related Genes and Possible Regulatory Mechanisms in Chronic Antibody-Mediated Rejection after Kidney Transplantation., PMID:40495508

A novel dominant-negative variant of IRF8 in a mother and son: Clinical, phenotypic and biological characteristics., PMID:40072380

Antimalarial Drug Artemotil Promotes Induction of Type 1 Regulatory T Cells., PMID:39607628

FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma., PMID:39542656

Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection., PMID:39532200

The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1., PMID:39451043

Reduction of myeloid-derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment., PMID:39390760

Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection., PMID:39359232

Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1., PMID:38953362

Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168

Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets., PMID:38788537

The role of PANoptosis in renal vascular endothelial cells: Implications for trichloroethylene-induced kidney injury., PMID:38714087

An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer., PMID:38519913

Exploration of the shared gene signatures and biological mechanisms between ischemia-reperfusion injury and antibody-mediated rejection in renal transplantation., PMID:38266883

Interferon-regulatory factor-1 boosts bevacizumab cardiotoxicity by the vascular endothelial growth factor A/14-3-3γ axis., PMID:38234115

Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody., PMID:38164171

Interferon gamma immunoPET imaging to evaluate response to immune checkpoint inhibitors., PMID:38130991

Role of Cherry Valley duck IRF1 mediated signal pathway in host anti-duck Tembusu virus., PMID:37979488

IL-33 Suppresses the Progression of Atherosclerosis via the ERK1/2-IRF1-VCAM-1 Pathway., PMID:37957490

Expression of programmed death-ligand 1, IRF1 and CD8 T lymphocyte infiltration in a primary subset of breast cancer patients in Sudan., PMID:37876597

Human inborn errors of immunity associated with IRF4., PMID:37809068

Targeting PI3Kα increases the efficacy of anti-PD-1 antibody in cervical cancer., PMID:37469254

IFNγ Transcribed by IRF1 in CD4+ Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis., PMID:37199578

Requirement of scavenger receptors for activation of the IRF-3/IFN-β/STAT-1 pathway in TLR4-mediated production of NO by LPS-activated macrophages., PMID:37059259

Type I interferon score is associated with the severity and poor prognosis in anti-MDA5 antibody-positive dermatomyositis patients., PMID:37006269

A specific anti-COVID-19 BNT162b2 vaccine-induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients., PMID:36969367

CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner., PMID:36930652

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia., PMID:36857629

Probiotics Alleviate Food Protein Allergy in Mice by Activating TLR4 Signaling Pathway., PMID:36815217

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion., PMID:35810186

Traditional Chinese Medicine Pien-Tze-Huang Inhibits Colorectal Cancer Growth and Immune Evasion by Reducing β-catenin Transcriptional Activity and PD-L1 Expression., PMID:35185580

BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer., PMID:35083874

Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling., PMID:35027670

Endotoxin-Stimulated Hepatic Stellate Cells Augment Acetaminophen-Induced Hepatocyte Injury., PMID:34954210

T cell and memory B cell responses in tetravalent DNA, tetravalent inactivated and tetravalent live-attenuated prime-boost dengue vaccines in rhesus macaques., PMID:34823910

Functional screen of inflammatory bowel disease genes reveals key epithelial functions., PMID:34758847

SOX10 Regulates Melanoma Immunogenicity through an IRF4-IRF1 Axis., PMID:34728538

Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells., PMID:34536158

BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression., PMID:34301753

Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19., PMID:34108657

A rapid method for solubilization of chimeric human interferon regulatory factor-1 (IRF-1) protein in Escherichia coli., PMID:33721170

Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance., PMID:33554047

MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298

Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy., PMID:33291616

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes., PMID:33278357

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion., PMID:33171124

m6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy., PMID:32964498

Variation in genes implicated in B-cell development and antibody production affects susceptibility to pemphigus., PMID:32926429

Dendritic cells' characteristics in patients with treated systemic lupus erythematosus., PMID:32730703

Cyclophilin inhibitors restrict Middle East respiratory syndrome coronavirus via interferon-λ in vitro and in mice., PMID:32616594

Datasheet

Document Download

Anti-IRF1 Antibody (R1N19).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-IRF1 Antibody (R1N19) [RHC84402]
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