Catalog No.
YHC27901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu80-Asp333
Predicted molecular weight
30.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07858
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APP secretase, CPSB, Cathepsin B, Cathepsin B1, CTSB, APPS, SARS-like Coronaviruses
Unveiling the Role of Cathepsins on Lung Function in Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis., PMID:40502432
Causal effects and plasma protein mediators between type 2 diabetes and erectile dysfunction: a Mendelian randomization study., PMID:40463815
Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia., PMID:40457023
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy., PMID:40451585
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes., PMID:40448432
Identification, Expression Profiling, Microbial Binding, and Agglutination Analyses of Two Cathepsin B Genes in Black Rockfish (Sebastes schlegelii)., PMID:40422803
Identification of TRPV1-Inhibitory Peptides from Takifugu fasciatus Skin Hydrolysate and Their Skin-Soothing Mechanisms., PMID:40422786
Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 Mpro and Cathepsin., PMID:40415551
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage., PMID:40414453
The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B., PMID:40411408
TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages., PMID:40409189
Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells., PMID:40394663
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes., PMID:40387924
Combined effects and potential mechanisms of volatile organic compounds on thyroid disease in the US population: An integrated epidemiological and computational toxicology study., PMID:40378728
NF-kappa-B inhibitor alpha mediates cancer stemness characteristics in oral squamous cell carcinoma by interacting with cathepsin B., PMID:40316102
Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis., PMID:40214957
Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2., PMID:40205686
Cathepsin B promotes optic nerve axonal regeneration., PMID:40177832
Salmonella Typhi serine threonine kinase T4519 induces lysosomal membrane permeabilization by manipulating Toll-like receptor 2-Cystatin B-Cathepsin B-NF-κB-reactive oxygen species pathway and promotes survival within human macrophages., PMID:40168426
Identification and expression analysis of cathepsin B genes in Myzus persicae (Hemiptera: Aphididae) and their response to environmental stresses., PMID:40162632
Vanillic acid inhibits TGF-β type I receptor to protect bone marrow mesenchymal stem cells from radiation-induced bystander effects., PMID:40104744
Function of lamp2 Gene Response to Vibrio vulnificus Infection and LPS Stimulation in the Half-Smooth Tongue Sole (Cynoglossus semilaevis)., PMID:40076623
Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene., PMID:40063555
The SGLT2 inhibitor dapagliflozin suppresses endothelial cell pyroptosis mediated by the NF-κB/NLRP3 pathway through downregulation of CTSB., PMID:40058708
Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer., PMID:40057469
Stimuli-responsive polymer-dasatinib prodrug to reprogram cancer-associated fibroblasts for boosted immunotherapy., PMID:40054628
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes., PMID:40053464
Unraveling the Role of Cathepsin B Variants in Polycystic Ovary Syndrome: Insights from a Case-Control Study and Computational Analyses., PMID:40044993
The therapeutic potential of (R)-carvedilol in Huntington's disease through enhancement of autophagy-lysosomal pathway via GSK-3β inhibition., PMID:40011132
In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction., PMID:40007784
A Dual-Targeted Molecule for Disease-Activatable Proteolysis Targeting Chimeras and Targeted Radionuclide Therapy of Cancer., PMID:39989465
A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection., PMID:39964716
Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis., PMID:39962054
The molecular mechanism by which CTSB degrades FPN to disrupt macrophage iron homeostasis and promote the progression of atherosclerosis., PMID:39960586
Cathepsin B prevents cell death by fragmentation and destruction of pathological amyloid fibrils., PMID:39955315
Association Analysis of the Circulating Proteome With Sarcopenia-Related Traits Reveals Potential Drug Targets for Sarcopenia., PMID:39949133
Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning., PMID:39929099
Identifying novel drug targets for calcific aortic valve disease through Mendelian randomization., PMID:39922081
Development of ASGR-Mediated Hepatocyte-Targeting Cytotoxic Drug Conjugates with CTSB-Cleavable Linkers Incorporating Succinimide and Succinic Acid Monoamide., PMID:39918134
Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation., PMID:39905520
Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics., PMID:39896814
Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer's Disease., PMID:39896474
Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1., PMID:39894408
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle., PMID:39878121
The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment., PMID:39842563
A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson's disease., PMID:39837893
Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque., PMID:39814777
NR1D1 Inhibition Enhances Autophagy and Mitophagy in Alzheimer's Disease Models., PMID:39812544
hCeO2@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway., PMID:39802379
miR-21 and cathepsin B in familial Mediterranean fever: novel findings regarding their impact on disease severity., PMID:39779193
For research use only. Not for human or drug use.
