Catalog No.
RHC09801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, Trk A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P04629
Applications
FCM, IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4 ℃ short term (1-2 weeks).
Store at -20 ℃ 12 months.
Store at -80 ℃ long term.
Clone ID
R1B31
Author Correction: Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain., PMID:40269189
A practical approach to better identify NTRK 1-3 fusion-positive mesenchymal neoplasms by pan-Trk immunohistochemistry., PMID:40232379
Combined Chemotherapy-Immunotherapy for Advanced Biliary Tract Cancer (BTC): A Clinical, Genomic, and Biomarker Analysis., PMID:40167580
Spitz Spindle Cell/Reed Nevus With SQSTM1 :: NTRK2 Fusion and Atypical Features in an Older Male Patient: A Case Report and Review of Literature., PMID:39980385
Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain., PMID:39955330
NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas., PMID:39839837
Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models., PMID:39589827
TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma., PMID:38482675
Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer., PMID:38347302
Canadian Multicentric Pan-TRK (CANTRK) Immunohistochemistry Harmonization Study., PMID:37972928
Toxic Epidermal Necrolysis and Stevens - Johnson Syndrome Following Sintilimab Administration in a Non-Small Cell Lung Cancer Patient: A Case Report., PMID:37936597
A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review., PMID:37735390
Pan-TRK immunohistochemistry as screening tool for NTRK fusions: A diagnostic workflow for the identification of positive patients in clinical practice., PMID:37545217
The Pan-TRK Antibody is a Sensitive and Specific Tool for the Detection of NTRK Fusion Genes., PMID:37017998
A systematic comparison of pan-Trk immunohistochemistry assays among multiple cancer types., PMID:36759438
Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways., PMID:36575400
Low-grade tracheal adenocarcinoma with ETV6::NTRK3 fusion: unique morphology akin to subsets of sinonasal low-grade non-intestinal-type adenocarcinoma., PMID:35670854
A rare case of recurrent ovarian cancer with TPM3-NTRK1 gene rearrangement: A case report., PMID:35251641
Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers., PMID:35237889
Dermal lipofibromatosis-like neural tumor., PMID:35195930
The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908
Unique genomic alterations of cerebrospinal fluid cell-free DNA are critical for targeted therapy of non-small cell lung cancer with leptomeningeal metastasis., PMID:34793951
Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis., PMID:34671549
Applicability of pan-TRK immunohistochemistry for identification of NTRK fusions in lung carcinoma., PMID:33963267
Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients., PMID:33600668
Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix., PMID:33208671
Comprehensive analysis of ALK, ROS1 and RET rearrangements in locally advanced rectal cancer., PMID:33168793
Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related Kinase A., PMID:33153070
Harmonization of Molecular Testing for Non-Small Cell Lung Cancer: Emphasis on PD-L1., PMID:33102215
Identification of Actionable Fusions as an Anti-EGFR Resistance Mechanism Using a Circulating Tumor DNA Assay., PMID:33015522
Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions., PMID:32860002
Clinical Significance of Trk Receptor Expression as a New Therapeutic Target in Hepatocellular Carcinoma., PMID:32623639
Nerve growth factor from Indian Russell's viper venom (RVV-NGFa) shows high affinity binding to TrkA receptor expressed in breast cancer cells: Application of fluorescence labeled RVV-NGFa in the clinical diagnosis of breast cancer., PMID:32585227
NTRK and ALK rearrangements in malignant pleural mesothelioma, pulmonary neuroendocrine tumours and non-small cell lung cancer., PMID:32540558
Evolution and structure of clinically relevant gene fusions in multiple myeloma., PMID:32471990
NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases., PMID:31792356
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients., PMID:31653970
A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target., PMID:31640749
Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature., PMID:31567189
Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer., PMID:30986992
A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics., PMID:30700786
DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study., PMID:30584054
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast., PMID:30268765
Rapid Growth and Early Metastasis of Papillary Thyroid Carcinoma in an Adolescent Girl with Graves' Disease., PMID:30092570
Evaluation of pan-TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis-like neural tumour and histological mimics., PMID:29863809
Primary and Metastatic Melanoma With NTRK Fusions., PMID:29683819
Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors., PMID:29683818
Tropomyosin receptor kinase: a novel target in screened neuroendocrine tumors., PMID:29563190
Molecular pathology of lung cancer: current status and perspectives., PMID:29251665
Negative hyper-selection of metastatic colorectal cancer patients for anti-EGFR monoclonal antibodies: the PRESSING case-control study., PMID:29045518
For research use only. Not for human or drug use.
