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Anti-BIRC3/IAP2 Antibody (R1A77)

Catalog #:   RHG55501 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, IHC, IP, WB
Accession: Q13489
Overview

Catalog No.

RHG55501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000

Target

AIP1, API2, BIRC3, CIAP2, HAIP1, IAP homolog C, RNF49, MIHC, MALT2, Apoptosis inhibitor 2, IAP2, BIRC3

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13489

Applications

IF, IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4 ℃ short term (1-2 weeks). Store at -20 ℃ 12 months. Store at -80 ℃ long term.

Clone ID

R1A77

Data Image
  • Western blot
    Western blot analysis of IAP2 expression in Ramos cell lysate.
References

Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and rheumatoid arthritis., PMID:39913998

Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing., PMID:38175592

Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats., PMID:37398677

Clinical relevance of molecular aspects in extranodal marginal zone lymphoma: a critical appraisal., PMID:37389189

Targeting cIAPs attenuates CCl4-induced liver fibrosis by increasing MMP9 expression derived from neutrophils., PMID:34914932

Kaempferol sensitizes tumor necrosis factor-related apoptosis-inducing ligand-resistance chronic myelogenous leukemia cells to apoptosis., PMID:34820749

Ibrutinib With Rituximab in First-Line Treatment of Older Patients With Mantle Cell Lymphoma., PMID:34797699

BET Inhibition Enhances TNF-Mediated Antitumor Immunity., PMID:34782346

Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM)., PMID:34506616

Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations-NOTCH1, SF3B1, MYD88, BIRC3., PMID:34442029

Venetoclax Plus Rituximab in Relapsed Chronic Lymphocytic Leukemia: 4-Year Results and Evaluation of Impact of Genomic Complexity and Gene Mutations From the MURANO Phase III Study., PMID:32986498

Targeted next-generation sequencing reveals molecular heterogeneity in non-chronic lymphocytic leukemia clonal B-cell lymphocytosis., PMID:32738175

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications., PMID:32720348

Response in patients with BIRC3-mutated relapsed/refractory chronic lymphocytic leukemia treated with fixed-duration venetoclax and rituximab., PMID:32611578

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax., PMID:32206772

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial., PMID:32015491

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways., PMID:31831875

Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism., PMID:31654570

Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes., PMID:31631721

The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma., PMID:31521140

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia., PMID:31371416

Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia., PMID:31230372

LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p., PMID:31215169

Impact of gene mutations and chromosomal aberrations on progression-free survival in chronic lymphocytic leukemia patients treated with front-line chemoimmunotherapy: Clinical practice experience., PMID:31054420

Splenic marginal zone lymphomas in acquired C1-inhibitor deficiency: clinical and molecular characterization., PMID:30073422

Normal serum protein electrophoresis and mutated IGHV genes detect very slowly evolving chronic lymphocytic leukemia patients., PMID:29745034

A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity., PMID:29679556

Genetic landscape of ultra-stable chronic lymphocytic leukemia patients., PMID:29365086

Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis., PMID:29307797

Zoledronic acid overcomes chemoresistance by sensitizing cancer stem cells to apoptosis., PMID:29300112

Novel prognostic molecular factors: a quantum leap in the field of chronic lymphocytic leukemia., PMID:28994094

Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL., PMID:28592889

[Chronic lymphocytic leukemia: pathophysiology and current therapy]., PMID:28592762

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups., PMID:28584254

Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia., PMID:28582465

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer., PMID:28481875

Distinct molecular genetics of chronic lymphocytic leukemia in Taiwan: clinical and pathogenetic implications., PMID:28255015

MALT lymphoma: A paradigm of NF-κB dysregulation., PMID:27452667

Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy., PMID:27226433

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors., PMID:27198719

CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia., PMID:27109509

Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma., PMID:27070702

Genomic Features: Impact on Pathogenesis and Treatment of Chronic Lymphocytic Leukemia., PMID:26890126

Chronic lymphocytic leukemia (CLL)-Then and now., PMID:26690614

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations., PMID:26675346

A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia., PMID:26630574

[Molecular Prognostic Markers and Their Clinical Relevance in Chronic Lymphocytic Leukemia]., PMID:26489496

c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival., PMID:26096449

The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia., PMID:25963298

Mutations in chronic lymphocytic leukemia and how they affect therapy choice: focus on NOTCH1, SF3B1, and TP53., PMID:25696844

Datasheet
$ 290
Product specifications
50 μg 290 100 μg 484

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For research use only. Not for human or drug use.

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Anti-BIRC3/IAP2 Antibody (R1A77) [RHG55501]
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