Catalog No.
RHK53801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Inositol polyphosphate-5-phosphatase of 145 kDa, inositol polyphosphate-5-phosphatase, 145kDa, INPP5D, p150Ship, INPP5D
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92835
Applications
FCM, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4 ℃ short term (1-2 weeks).
Store at -20 ℃ 12 months.
Store at -80 ℃ long term.
Clone ID
R1A67
SHIP-1 Differentially Regulates IgE-Induced IL-10 and Antiviral Responses in Human Monocytes., PMID:39668409
Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas., PMID:38701792
SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism., PMID:37916396
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints., PMID:37749326
Case report: Clinicopathological and molecular characteristics of pediatric-type follicular lymphoma., PMID:37539011
Multistep IgE Mast Cell Desensitization Is a Dose- and Time-Dependent Process Partially Regulated by SHIP-1., PMID:36881903
Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro., PMID:34721399
Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs., PMID:33326804
CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis., PMID:31950225
PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer., PMID:31516390
Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus., PMID:31451659
Monomer hapten and hapten-specific IgG inhibit mast cell activation evoked by multivalent hapten with different mechanisms., PMID:31339552
Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells., PMID:31004680
Epstein-Barr virus microRNAs regulate B cell receptor signal transduction and lytic reactivation., PMID:30615681
Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells., PMID:30341350
IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells., PMID:30210494
Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB., PMID:29351998
Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation., PMID:29138425
IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice., PMID:29138419
Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a., PMID:28409542
Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway., PMID:28341640
Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils., PMID:27999175
FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells., PMID:27456487
Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice., PMID:26518471
CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs., PMID:26422753
B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens., PMID:26152931
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia., PMID:25799995
Identification of SHIP-1 and SHIP-2 homologs in channel catfish, Ictalurus punctatus., PMID:25743379
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells., PMID:25312647
MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis., PMID:24708712
SHIP1 and the negative control of mast cell/basophil activation by supra-optimal antigen concentrations., PMID:24679713
SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation., PMID:24598798
Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells., PMID:24210883
Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection., PMID:22535180
The SH2-domain of SHIP1 interacts with the SHIP1 C-terminus: impact on SHIP1/Ig-α interaction., PMID:22182704
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy., PMID:22078222
A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling., PMID:21622861
Role of SHIP-1 in the adaptive immune responses to aeroallergen in the airway., PMID:21151496
Concerted action of Helios and Ikaros controls the expression of the inositol 5-phosphatase SHIP., PMID:20602434
Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2., PMID:19477690
C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1., PMID:19423845
Activation of human peripheral IgM+ B cells is transiently inhibited by BCR-independent aggregation of Fc gammaRIIB., PMID:18832691
FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation., PMID:18791164
Functionality of the IgA Fc receptor (FcalphaR, CD89) is down-regulated by extensive engagement of FcepsilonRI., PMID:18700185
Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models., PMID:18625911
A mouse Fcgamma-Fcepsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases., PMID:17949802
A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity., PMID:17942927
The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production., PMID:17579026
Peritoneal cell-derived mast cells: an in vitro model of mature serosal-type mouse mast cells., PMID:17475876
A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity., PMID:17404292
For research use only. Not for human or drug use.
