Catalog No.
YXX54201
Expression system
E. coli
Species
Plasmodium falciparum (malaria parasite P. falciparum)
Protein length
Ser387-Asp1035
Predicted molecular weight
71.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A0A0K2JPB8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
VAR2CSA
Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour-Derived Extracellular Vesicles., PMID:40527727
A machine learning framework to identify complex physicochemical features of B cell epitopes., PMID:40321766
Use of the Malaria Protein VAR2CSA for the Detection of Small Extracellular Vesicles to Diagnose Adenocarcinoma., PMID:40241173
Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion., PMID:39804934
Cytoadhesion of Plasmodium falciparum-Infected Red Blood Cells Changes the Expression of Cytokine-, Histone- and Antiviral Protein-Encoding Genes in Brain Endothelial Cells., PMID:39630601
Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental Plasmodium falciparum Malaria., PMID:39585195
Transcription and Copy Number Variation of Plasmodium falciparum var2csa among Nonpregnant Malaria Patients in Thailand., PMID:39561405
Combining rVAR2 and Anti-EpCAM to Increase the Capture Efficiency of Non-Small-Cell Lung Cancer Cell Lines in the Flow Enrichment Target Capture Halbach (FETCH) Magnetic Separation System., PMID:39337304
Antibody response to malaria vaccine candidates in pregnant women with Plasmodium falciparum and Schistosoma haematobium infections., PMID:38587985
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine., PMID:38437239
Acquisition of antibodies that block Plasmodium falciparum adhesion to placental receptor chondroitin sulfate A with increasing gravidity in Malian women., PMID:38274790
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture., PMID:38270586
Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites., PMID:38117828
Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA., PMID:37932470
Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A., PMID:37828011
Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso., PMID:37754682
VAR2CSA Ectodomain Labeling in Plasmodium falciparum Infected Red Blood Cells and Analysis via Flow Cytometry., PMID:37575395
Are high avidity antibodies to Plasmodium falciparum antigens preferentially transferred across the placenta of premature and term babies?, PMID:37515848
Malaria Biomimetic for Tumor Targeted Drug Delivery., PMID:37435892
A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein., PMID:37396303
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?, PMID:37228009
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M., PMID:37156765
Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies., PMID:37091678
Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection., PMID:36746966
The Rapid and Spontaneous Postpartum Clearance of Plasmodium falciparum Is Related to Expulsion of the Placenta., PMID:36740589
A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites., PMID:36515978
Disulfide bond and crosslinking analyses reveal inter-domain interactions that contribute to the rigidity of placental malaria VAR2CSA structure and formation of CSA binding channel., PMID:36470436
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil., PMID:36457056
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA., PMID:36383559
A mutated glycosaminoglycan-binding domain functions as a novel probe to selectively target heparin-like epitopes on tumor cells., PMID:36265583
A nuclear redox sensor modulates gene activation and var switching in Plasmodium falciparum., PMID:35939693
Expression of Large Full-Length PfEMP1 Proteins in HEK293 Cells., PMID:35881353
Extraction and Immunoprecipitation of VAR2CSA, the PfEMP1 Associated with Placental Malaria., PMID:35881351
Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assay., PMID:35838346
Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo., PMID:35831417
Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria., PMID:35631041
Plasmodium falciparum in Aotus nancymaae: A New Model for Placental Malaria., PMID:35290467
Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women., PMID:35248084
A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates., PMID:35103596
Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait., PMID:35026728
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer., PMID:34966741
PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait., PMID:34909438
Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity., PMID:34799664
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility., PMID:34762909
An Invariant Protein That Colocalizes With VAR2CSA on Plasmodium falciparum-Infected Red Cells Binds to Chondroitin Sulfate A., PMID:34718641
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination., PMID:34611164
Can complement fix placental malaria?, PMID:34503499
Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine., PMID:34450283
Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women., PMID:34425801
High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women., PMID:34220804
For research use only. Not for human or drug use.
