Catalog No.
YXX54201
Expression system
E. coli
Species
Plasmodium falciparum (malaria parasite P. falciparum)
Protein length
Ser387-Asp1035
Predicted molecular weight
71.91 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A0A0K2JPB8
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
VAR2CSA
Note
For research use only.
High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women., PMID:34220804
Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women., PMID:34425801
Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine., PMID:34450283
Can complement fix placental malaria?, PMID:34503499
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination., PMID:34611164
An Invariant Protein That Colocalizes With VAR2CSA on Plasmodium falciparum-Infected Red Cells Binds to Chondroitin Sulfate A., PMID:34718641
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility., PMID:34762909
Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity., PMID:34799664
PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait., PMID:34909438
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer., PMID:34966741
Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait., PMID:35026728
A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates., PMID:35103596
Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women., PMID:35248084
Plasmodium falciparum in Aotus nancymaae: A New Model for Placental Malaria., PMID:35290467
Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria., PMID:35631041
Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo., PMID:35831417
Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assay., PMID:35838346
Extraction and Immunoprecipitation of VAR2CSA, the PfEMP1 Associated with Placental Malaria., PMID:35881351
Expression of Large Full-Length PfEMP1 Proteins in HEK293 Cells., PMID:35881353
A nuclear redox sensor modulates gene activation and var switching in Plasmodium falciparum., PMID:35939693
A mutated glycosaminoglycan-binding domain functions as a novel probe to selectively target heparin-like epitopes on tumor cells., PMID:36265583
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA., PMID:36383559
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil., PMID:36457056
Disulfide bond and crosslinking analyses reveal inter-domain interactions that contribute to the rigidity of placental malaria VAR2CSA structure and formation of CSA binding channel., PMID:36470436
A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites., PMID:36515978
The Rapid and Spontaneous Postpartum Clearance of Plasmodium falciparum Is Related to Expulsion of the Placenta., PMID:36740589
Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection., PMID:36746966
Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies., PMID:37091678
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M., PMID:37156765
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?, PMID:37228009
A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein., PMID:37396303
Malaria Biomimetic for Tumor Targeted Drug Delivery., PMID:37435892
Are high avidity antibodies to Plasmodium falciparum antigens preferentially transferred across the placenta of premature and term babies?, PMID:37515848
VAR2CSA Ectodomain Labeling in Plasmodium falciparum Infected Red Blood Cells and Analysis via Flow Cytometry., PMID:37575395
Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso., PMID:37754682
Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A., PMID:37828011
Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA., PMID:37932470
Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites., PMID:38117828
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture., PMID:38270586
Acquisition of antibodies that block Plasmodium falciparum adhesion to placental receptor chondroitin sulfate A with increasing gravidity in Malian women., PMID:38274790
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine., PMID:38437239
Antibody response to malaria vaccine candidates in pregnant women with Plasmodium falciparum and Schistosoma haematobium infections., PMID:38587985
Combining rVAR2 and Anti-EpCAM to Increase the Capture Efficiency of Non-Small-Cell Lung Cancer Cell Lines in the Flow Enrichment Target Capture Halbach (FETCH) Magnetic Separation System., PMID:39337304
Transcription and Copy Number Variation of Plasmodium falciparum var2csa among Nonpregnant Malaria Patients in Thailand., PMID:39561405
Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental Plasmodium falciparum Malaria., PMID:39585195
Cytoadhesion of Plasmodium falciparum-Infected Red Blood Cells Changes the Expression of Cytokine-, Histone- and Antiviral Protein-Encoding Genes in Brain Endothelial Cells., PMID:39630601
Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion., PMID:39804934
Use of the Malaria Protein VAR2CSA for the Detection of Small Extracellular Vesicles to Diagnose Adenocarcinoma., PMID:40241173
A machine learning framework to identify complex physicochemical features of B cell epitopes., PMID:40321766
Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour-Derived Extracellular Vesicles., PMID:40527727
For research use only. Not for human or drug use.
