Catalog No.
EHD25201
Expression system
Mammalian cells
Species
Homo sapiens (Human)
Protein length
Gln25-Arg471
Predicted molecular weight
53.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17643
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
5,6-dihydroxyindole-2-carboxylic acid oxidase, Glycoprotein 75, CAS2, TYRP1, TRP-1, TYRRP, TRP1, Catalase B, TYRP, Melanoma antigen gp75, TRP, DHICA oxidase, Tyrosinase-related protein 1
Metabolome and transcriptome analyses reveal the mechanism underlying the differences in skin development between the two duck breeds during embryonic stage., PMID:40499236
Polygenic Risk Score Analysis of 37 SNPs Associated with Melanoma Risk in Colombian Population., PMID:40429816
RNA sequencing and genome-wide association analysis reveal key genes responsible for different feather colors in Youjiang goose., PMID:40424883
Mgat4b-mediated selective N-glycosylation regulates melanocyte development and melanoma progression., PMID:40424122
Agarose Microgel-Based In Situ Cleavable Immuno-Rolling Circle Amplification for Multiplexed Single-Molecule Quantitation on Single Extracellular Vesicles., PMID:40320637
The Role of Two Tyrosinase-Like Glycoenzymes in Defining the Final Hue of Parrot Plumage., PMID:40195888
Disentangling the molecular mechanisms underlying yellow body coloration in a soft-shelled turtle., PMID:40091532
Association of Inherited Genetic Variants with Multiple Primary Melanoma., PMID:40036058
Melanin deposition and key molecular features in Xenopus tropicalis oocytes., PMID:40016733
In Vitro and In Silico Studies of Maculosin as a Melanogenesis and Tyrosinase Inhibitor., PMID:40005169
Dynamic Chromatin Accessibility and Transcriptional Regulation in the Eyes of Red Tilapia (Oreochromis sp.) in Response to Wintering Stress., PMID:39937323
Dynamic changes in the skin transcriptome for the melanin pigmentation in embryonic chickens., PMID:39693959
Research progress on pathogenesis of skin pigmentation in chronic liver disease., PMID:39689154
Assessment of Bioactivity of Homalomena aromatica Essential Oil From Northeast India Through Combinative In Vitro and In Silico Approaches., PMID:39601489
High-throughput, multiplexed quantification, and sorting of single EVs at single-molecule level., PMID:39553943
Plumage polymorphism in the black sparrowhawk (Accipiter melanoleucus) is strongly associated with the expression level of agouti signaling protein., PMID:39552347
Characterization and functional analysis of pl-miR-2188 in melanin synthesis in leopard coral grouper (Plectropomus leopardus)., PMID:39491612
Modulatory effects of oxytocin on normal human cultured melanocyte proliferation, migration, and melanogenesis., PMID:39388927
Tyrp1 is the mendelian determinant of the Axolotl (Ambystoma mexicanum) copper mutant., PMID:39333770
Discovery of Indole-Thiourea Derivatives as Tyrosinase Inhibitors: Synthesis, Biological Evaluation, Kinetic Studies, and In Silico Analysis., PMID:39273583
PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickens., PMID:39271811
Transcriptome-based screening and validation of key genes for wool color in cashmere goats., PMID:39259488
The biochemistry of melanogenesis: an insight into the function and mechanism of melanogenesis-related proteins., PMID:39228912
The amino acid transporter SLC16A10 promotes melanogenesis by facilitating the transportation of phenylalanine., PMID:39171634
Differentiation of cultured hair follicle neural crest stem cells into functional melanocytes., PMID:39170163
Transcriptomic and Metabolomic Analyses Reveal Molecular Regulatory Networks for Pigmentation Deposition in Sheep., PMID:39125816
Gut Microbiome-Driven metabolites influence skin pigmentation in TYRP1 mutant Oujiang Color Common Carp., PMID:39094713
UVB-induced TRPS1 regulates MITF transcription activity to promote skin pigmentation., PMID:39074626
Mechanism of the wine pomace tannin in hyperpigmentation inhibition: Impact on signaling pathways, cell proliferation, and tyrosinase activity., PMID:39038577
Kunzea Ericoides (Kanuka) Leaf Extracts Show Moisturisation, Antioxidant, and UV Protection Effects in HaCaT Cells and Anti-melanogenesis Effects in B16F10 Cells., PMID:39009952
New record of strawberry leopard (Panthera pardus) in Selous Game Reserve, Tanzania., PMID:38979004
Unveiling novel targets in melanoma under melanogenesis stimulation and photodynamic therapy by redox proteomics., PMID:38961772
Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp., PMID:38956500
A Nude Mouse Model of Xenografted Hypertrophic Scar Cells to Test Therapeutics in the Skin., PMID:38940034
PAX3 haploinsufficiency in Maine Coon cats with dominant blue eyes and hearing loss resembling the human Waardenburg syndrome., PMID:38869246
Tokishakuyakusan alleviates ultraviolet-induced skin pigmentation by decreasing the expression of melanogenesis-related enzymes., PMID:38762211
Comparative transcriptomic analyses reveal key genes underlying melanin distribution during embryonic development in geese (Anser anser)., PMID:38748993
Capsaicin combined with stem cells improved mitochondrial dysfunction in PIG3V cells, an immortalized human vitiligo melanocyte cell line, by inhibiting the HSP70/TLR4/mTOR/FAK signaling axis., PMID:38734811
Unique feather color characteristics and transcriptome analysis of hair follicles in Liancheng White ducks., PMID:38718539
Transcriptional variations at perilesional site in vitiligo patients: probably a fight for cell-survival., PMID:38662224
Mycosporine-Like Amino Acids as a Potential Inhibitor of Tyrosinase-Related Protein 1: Computational Screening, Pharmacokinetics, and Molecular Dynamics Simulation., PMID:38652428
Anti-Melanogenic Activity of Undecylprodigiosin, a Red Pigment Isolated from a Marine Streptomyces sp. SNA-077., PMID:38651201
Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure., PMID:38577337
Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis., PMID:38517309
Triphenyltin induced darker body coloration by disrupting melanocortin system and pteridine metabolic pathway in a reef fish, Amphiprion ocellaris., PMID:38461573
2,4,6-Triphenyl-1-hexene, an Anti-Melanogenic Compound from Marine-Derived Bacillus sp. APmarine135., PMID:38393043
CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes., PMID:38336975
Establishment of a synchronized tyrosinase transport system revealed a role of Tyrp1 in efficient melanogenesis by promoting tyrosinase targeting to melanosomes., PMID:38291221
Treatment of hypopigmented burn hypertrophic scars with short-term topical tacrolimus does not lead to repigmentation., PMID:38225772
Differential expression of ASIP transcripts reveals genetic mechanism underpinning black-tail independence from body plumage in yellow-bodied chickens., PMID:38194424
For research use only. Not for human or drug use.
