Catalog No.
YHD91101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser60-Ser250
Predicted molecular weight
23.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30793
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GCH1, GTP cyclohydrolase I, DYT5, GTP cyclohydrolase 1, GTP-CH-I, GCH
Screening for biomarkers of bronchopulmonary dysplasia: a bioinformatics analysis., PMID:40386354
Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets., PMID:40329437
Association of GCH1 polymorphism with Parkinson disease susceptibility: A meta-analysis., PMID:40258736
Clinical and Basic Research on Dopa-Responsive Dystonia: Neuropathological and Neurochemical Findings., PMID:40109402
Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis., PMID:40022222
Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc-/GPX4 pathway., PMID:39944356
Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling., PMID:39941119
Functional movement disorders in dopa-responsive dystonia., PMID:39848138
Pathogenic Variant in the 5'-Untranslated Region of GCH1 and Clinical Heterogeneity in a Chinese Family with Dopa-Responsive Dystonia., PMID:39801809
Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation., PMID:39723384
CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1., PMID:39541845
Association of Amyotrophic Lateral Sclerosis and Dopa-responsive dystonia in a Tunisian patient., PMID:39531950
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain., PMID:39178277
Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration., PMID:39153477
Enhancement of Haloperidol-Induced Catalepsy by GPR143, an l-DOPA Receptor, in Striatal Cholinergic Interneurons., PMID:39142836
Comparative Transcriptome Analysis Reveals Differential Cutaneous Gene Expression in the Color Variation of Two Ornamental Discus, Red Melon and Red Cover., PMID:39140294
Characterization of Dnajc12 knockout mice, a model of hypodopaminergia., PMID:39026821
Autosomal Recessive Guanosine Triphosphate Cyclohydrolase I Deficiency: Redefining the Phenotypic Spectrum and Outcomes., PMID:39001623
Citronellal improves endothelial dysfunction by affecting the stability of the GCH1 protein., PMID:38993132
De novo p.Glu61Ter mutation in GCH1 in a Moroccan patient with dopa-responsive dystonia: a case report., PMID:38974698
Inhibition of Ferroptosis by Mesenchymal Stem Cell-Derived Exosomes in Acute Spinal Cord Injury: Role of Nrf2/GCH1/BH4 Axis., PMID:38955534
Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression., PMID:38906233
Identification of an inflammatory response-related gene prognostic signature and immune microenvironment for cervical cancer., PMID:38903179
Genetic Influence on Capsaicin Tolerance: Precision Nutrition Implications for Obesity Handling., PMID:38810602
Sex Differences in Dystonia., PMID:38778444
Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells., PMID:38757341
Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury., PMID:38689083
FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications., PMID:38615304
An Inversion Affecting the GCH1 Gene as a Novel Finding in Dopa-Responsive Dystonia., PMID:38497520
Triphenyltin induced darker body coloration by disrupting melanocortin system and pteridine metabolic pathway in a reef fish, Amphiprion ocellaris., PMID:38461573
Dissecting genetic architecture of rare dystonia: genetic, molecular and clinical insights., PMID:38458754
Host transcriptomics and machine learning for secondary bacterial infections in patients with COVID-19: a prospective, observational cohort study., PMID:38310908
Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways., PMID:38290383
Large-Scale Screening: Phenotypic and Mutational Spectrum in Isolated and Combined Dystonia Genes., PMID:38214203
Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1., PMID:38084654
Endogenous chemicals guard health through inhibiting ferroptotic cell death., PMID:38059412
SRSF1 inhibits ferroptosis and reduces cisplatin chemosensitivity of triple-negative breast cancer cells through the circSEPT9/GCH1 axis., PMID:38040194
A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis., PMID:37833746
Importance of targeted next-generation sequencing in pediatric patients with developmental epileptic encephalopathy., PMID:37820178
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis., PMID:37735250
Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview., PMID:37638996
Whole exome sequencing and clinical investigation of young onset dystonia: What can we learn?, PMID:37607452
Effects of DNA, RNA, and Protein Methylation on the Regulation of Ferroptosis., PMID:37497000
GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner., PMID:37463466
Implementation of a Drug Screening Platform to TargetGch1 Expression in Injured Mouse Dorsal Root Ganglion Neurons., PMID:37188109
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury., PMID:37184360
17β-Estradiol Suppresses Gastric Inflammatory and Apoptotic Stress Responses and Restores nNOS-Mediated Gastric Emptying in Streptozotocin (STZ)-Induced Diabetic Female Mice., PMID:36979006
Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions., PMID:36908807
Genetic screening of Filipinos suspected with familial Parkinson's disease: A pilot study., PMID:36774704
Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury., PMID:36735402
For research use only. Not for human or drug use.
