Catalog No.
AHK26801
Biological activity
Measured by its ability to inhibit anti-CD3 Ab induced IFN-gamma secretion by human peripheral blood mononuclear cells (PBMC). The ED50 for this effect is 0.5-3 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg20-Pro283
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y279
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein Z39Ig, CRIg, V-set and immunoglobulin domain-containing protein 4, VSIG4, Z39IG
Synovium-on-a-Chip Reveals Fibroblast-Macrophage Crosstalk Underpinning Joint Homeostasis and Evaluation of Gout Therapies., PMID:40411870
VSIG4 Promotes Tumour-Associated Macrophage M2 Polarization and Immune Escape in Colorectal Cancer via Fatty Acid Oxidation Pathway., PMID:40405491
A serum biomarker panel and miniarray detection system for tracking disease activity and flare risk in lupus nephritis., PMID:40375995
Transcriptomic analysis of differential expression between surviving and nonsurviving patients infected by the SARS-CoV-2 Delta variant., PMID:40374692
VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity., PMID:40346775
Urinary V-Set Ig Domain-Containing Protein 4 and Immune Complexes for Tracking Lupus Nephritis and Renal Pathology., PMID:40331437
Perivascular RELMα-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis., PMID:40313955
VSIG4 Alleviates Intracranial Hemorrhage Injury by Regulating Oxidative Stress and Neuroinflammation in Macrophages via the NRF2/HO-1 Signaling Pathway., PMID:40302349
Comprehensive analysis of CMTM family and immune infiltration in esophageal carcinoma., PMID:40179060
Single-cell and spatial analyses reveal the effect of VSIG4+S100A10+TAMs on the immunosuppression of glioblastoma and anti-PD-1 immunotherapy., PMID:40127797
V-set and immunoglobulin domain containing 4 as a potential predictor of Alzheimer's disease and advanced aging., PMID:40116682
Plasma proteins predict kidney function trajectories in type 2 diabetes., PMID:39950984
Identification of potential drug targets for four site-specific cancers by integrating human plasma proteome with genome., PMID:39933395
VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1., PMID:39920772
The oncogenic functions of SPARCL1 in bladder cancer., PMID:39548034
Identification of PFKFB3 as a key factor in the development of colorectal cancer and immunotherapy resistance., PMID:39261380
Non-alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis., PMID:39143741
Causal relationship between complement C1QB and colorectal cancer: a drug target Mendelian randomization study., PMID:39109334
The immunomodulatory role of paracrine signalling factor VSIG4 in peritoneal metastases., PMID:39080370
Inhibition of the TCF12/VSIG4 axis by palbociclib diminishes the proliferation and migration of glioma cells and decreases the M2 polarization of glioma-associated microglia., PMID:38967729
The role of SPI1/VSIG4/THBS1 on glioblastoma progression through modulation of the PI3K/AKT pathway., PMID:38960279
Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types., PMID:38892347
V-set and immunoglobulin domain containing 4 inhibits oxidative stress, mitochondrial dysfunction, and inflammation to attenuate Parkinson's disease progression by activating the JAK2/STAT3 pathway., PMID:38759519
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production., PMID:38216011
Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction., PMID:38169731
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis., PMID:38113649
Comprehensive analyses for the coagulation and macrophage-related genes to reveal their joint roles in the prognosis and immunotherapy of lung adenocarcinoma patients., PMID:38022584
Integrating scRNA-seq to explore novel macrophage infiltration-associated biomarkers for diagnosis of heart failure., PMID:37974098
Cell-type-specific molecular characterization of cells from circulation and kidney in IgA nephropathy with nephrotic syndrome., PMID:37908345
Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients., PMID:37877121
Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis., PMID:37866785
Identification of differential immune cells and related diagnostic genes in patients with diabetic retinopathy., PMID:37773794
Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer., PMID:37684436
Identification of immune-related genes in the prognosis of head and neck cancer using a novel prognostic signature model., PMID:37620228
Tetraspan MS4A6D is a coreceptor of MHC class II antigen (MHC-II) that promotes macrophages-derived inflammation., PMID:37429063
VSIG4 interaction with heparan sulfates inhibits VSIG4-complement binding., PMID:37341346
VSIG4 Silencing Inhibits Glioblastoma Growth by Regulating the JAK2/STAT3 Pathway., PMID:37292180
Excavation of diagnostic biomarkers and construction of prognostic model for clear cell renal cell carcinoma based on urine proteomics., PMID:37260987
V-Set Immunoglobulin Domain-Containing Protein 4 as a Novel Serum Biomarker of Lupus Nephritis and Renal Pathology Activity., PMID:37163449
Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac Fibrosis After Myocardial Infarction., PMID:37153746
Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma., PMID:37097516
Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer., PMID:37073135
Integrative analysis of transcriptomic landscape and urinary signature reveals prognostic biomarkers for clear cell renal cell carcinoma., PMID:37035174
The Role of V-Set Ig Domain-Containing 4 in Chronic Kidney Disease Models., PMID:36836636
Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH., PMID:36745210
Therapeutic modulation of V Set and Ig domain-containing 4 (VSIG4) signaling in immune and inflammatory diseases., PMID:36642683
Novel plasma protein biomarkers from critically ill sepsis patients., PMID:36572854
Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes., PMID:36440192
The biology of VSIG4: Implications for the treatment of immune-mediated inflammatory diseases and cancer., PMID:36343787
IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer., PMID:36328145
For research use only. Not for human or drug use.
