Catalog No.
AHJ81401
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated human peripheral blood acute lymphoblastic leukemia cells (HSB2). When 5 x 10^4 cells/well are added to recombinant human ICAM5 (Cat #: AHJ81401) coated plates (25 µg/mL, 100 µL/well), >25% will adhere after 1 hour incubation at 37 ℃.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala28-Glu570
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UMF0
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Intercellular adhesion molecule 5, ICAM-5, ICAM5, TLN, Telencephalin, TLCN
Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics., PMID:40481979
Causal association between plasma proteins and lung adenocarcinoma: a two-sample mendelian randomization study., PMID:40468286
Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy., PMID:40148470
Large-scale plasma proteomics uncovers novel targets linking ambient air pollution and depression., PMID:40108257
Integrative Multi-omics Analysis and Mendelian Randomization Reveal Potential Therapeutic Targets and their Stratification in Lung Squamous Cell Carcinoma., PMID:39936431
LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro., PMID:39787147
Combined additive effects of neuronal membrane glycoprotein GPM6a and the intercellular cell adhesion molecule ICAM5 on neuronal morphogenesis., PMID:39352694
Involvement of ICAM5 in Carcinostasis Effects on LUAD Based on the ROS1-Related Prognostic Model., PMID:39318995
IL23R mutations associated with decreased risk of psoriasis lead to the differential expression of genes implicated in the disease., PMID:39306854
PLASMA PROTEOME, METABOLOME MENDELIAN RANDOMIZATION IDENTIFIES SEPSIS THERAPEUTIC TARGETS., PMID:39194222
Characterization of Inflammation/Immune-, Acute Phase-, Extracellular Matrix-, Adhesion-, and Serine Protease-Related Proteins in the Amniotic Fluid of Women With Early Preterm Prelabor Rupture of Membranes., PMID:39113666
Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation., PMID:39051921
Proteome-Wide Multicenter Mendelian Randomization Analysis to Identify Novel Therapeutic Targets for Lung Cancer., PMID:38824092
Genetic insight into putative causes of xanthelasma palpebrarum: a Mendelian randomization study., PMID:38601164
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma., PMID:38576019
Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study., PMID:38575325
Comprehensive genotyping analysis of single nucleotide polymorphisms responsible for beef marbling in Japanese Black cattle., PMID:38336623
DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression., PMID:38228798
Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers., PMID:37735436
Integrating genomics and proteomics data to identify candidate plasma biomarkers for lung cancer risk among European descendants., PMID:37679517
RANKL acts an unfavorable prognostic biomarker and potential target in advanced KRAS-mutated lung adenocarcinoma., PMID:37021520
Hypoxia-mediated chemotaxis and residence of macrophage in decidua by secreting VEGFA and CCL2 during normal pregnancy., PMID:36809184
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity., PMID:35772218
Role of chemokines in early pregnancy loss., PMID:35495608
Whole-genome sequencing reveals host factors underlying critical COVID-19., PMID:35255492
Proteomic profiling identifies novel proteins for genetic risk of severe COVID-19: the Atherosclerosis Risk in Communities Study., PMID:35212764
Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis., PMID:35189047
SAA1 regulates pro-labour mediators in term labour by activating YAP pathway., PMID:33719002
MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity., PMID:33467671
Receptor-Binding Assays of Enterovirus D68., PMID:32306362
Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts., PMID:32101770
ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome., PMID:31882402
Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome., PMID:31680833
Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid., PMID:31167912
Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization., PMID:30397341
Systematic Analysis of Gene Expression Profiles Controlled by hnRNP Q and hnRNP R, Two Closely Related Human RNA Binding Proteins Implicated in mRNA Processing Mechanisms., PMID:30214903
Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain., PMID:29720403
Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia., PMID:29311819
ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68., PMID:27923705
Genetic association study of systemic lupus erythematosus and disease subphenotypes in European populations., PMID:27021335
Aqueous Terminalia arjuna extract modulates expression of key atherosclerosis-related proteins in a hypercholesterolemic rabbit: A proteomic-based study., PMID:26934842
Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A., PMID:26789235
Blood Biomarkers in Moderate-To-Severe Traumatic Brain Injury: Potential Utility of a Multi-Marker Approach in Characterizing Outcome., PMID:26074866
Multivariate analysis of traumatic brain injury: development of an assessment score., PMID:25870583
ICAM-5: a neuronal dendritic adhesion molecule involved in immune and neuronal functions., PMID:25300135
Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions., PMID:25004970
Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2., PMID:24652679
Expression profiles of 507 proteins from a biotin label-based antibody array in human colorectal cancer., PMID:24366523
Subcellular localization of intercellular adhesion molecule-5 (telencephalin) in the visual cortex is not developmentally regulated in the absence of matrix metalloproteinase-9., PMID:23897576
Soluble ICAM-5, a product of activity dependent proteolysis, increases mEPSC frequency and dendritic expression of GluA1., PMID:23844251
For research use only. Not for human or drug use.
