Catalog No.
AHN36901
Biological activity
Measured by its binding ability in a functional ELISA. When rhEphA6 (Cat #: AHN36901) is immobilized at 2 μg/mL, 100 μL/well, it binds biotinylated rhEphrin-A3 with a linear range of 0.31-20 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Trp23-Val550
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UF33
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EHK2, Ephrin type-A receptor 6, EHK-2, EPHA6, HEK12, EPH homology kinase 2, EPH-like kinase 12, EK12
Hepatic transcriptome profiling unveils candidate genes in cattle with liver abscesses under the influence of beef genetics in dairy cattle., PMID:40489480
Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion., PMID:40228894
Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases., PMID:39415254
[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation]., PMID:39034804
A pan-cancer analysis of EphA family gene expression and its association with prognosis, tumor microenvironment, and therapeutic targets., PMID:38952552
Runs of Homozygosity Detection and Selection Signature Analysis for Local Goat Breeds in Yunnan, China., PMID:38540373
Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer., PMID:37906960
The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer., PMID:36598552
ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer., PMID:36053834
Pharmacogenetics of taxane-induced neurotoxicity in breast cancer: Systematic review and meta-analysis., PMID:35892315
Molecular Dynamics Simulation Investigation of the Binding and Interaction of the EphA6-Odin Protein Complex., PMID:35732074
Ephrin Receptors (Ephs) Expression in Thymic Epithelial Tumors: Prognostic Implications and Future Therapeutic Approaches., PMID:34943502
Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in Chemotherapy., PMID:33977106
Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients., PMID:33833937
A genome-wide association study for prolificacy in three Polish sheep breeds., PMID:33608865
Stem-like Cells from Invasive Breast Carcinoma Cell Line MDA-MB-231 Express a Distinct Set of Eph Receptors and Ephrin Ligands., PMID:33099474
Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma., PMID:32843430
IFNβ-induced exosomal linc-EPHA6-1 promotes cytotoxicity of NK cells by acting as a ceRNA for hsa-miR-4485-5p to up-regulate NKp46 expression., PMID:32652136
Podocyte RNA sequencing reveals Wnt- and ECM-associated genes as central in FSGS., PMID:32302353
Epigenetic age signatures in bones., PMID:32087494
Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis., PMID:31483918
Inhibition of EphA/Ephrin-A signaling using genetic and pharmacologic approaches improves recovery following traumatic brain injury in mice., PMID:31319723
A Pilot, Phase II, Randomized, Open-Label Clinical Trial Comparing the Neurotoxicity of Three Dose Regimens of Nab-Paclitaxel to That of Solvent-Based Paclitaxel as the First-Line Treatment for Patients with Human Epidermal Growth Factor Receptor Type 2-Negative Metastatic Breast Cancer., PMID:31023863
Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells., PMID:30789269
Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats., PMID:30071829
Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis., PMID:29955086
Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer., PMID:29552165
Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth., PMID:29535823
EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population., PMID:29208002
Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy., PMID:27582484
EphA5 and EphA6: regulation of neuronal and spine morphology., PMID:27489614
Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study., PMID:27271309
Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue., PMID:26941654
Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review., PMID:26585358
Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry., PMID:26384852
Identification of disrupted AUTS2 and EPHA6 genes by array painting in a patient carrying a de novo balanced translocation t(3;7) with intellectual disability and neurodevelopment disorder., PMID:26333717
EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression., PMID:26041887
Next-generation sequencing in African Americans with colorectal cancer., PMID:25941412
Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans., PMID:25941411
Novel recurrently mutated genes in African American colon cancers., PMID:25583493
EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice., PMID:25166508
A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas., PMID:24945320
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy., PMID:24795639
Comparative analysis of gene transcripts for cell signaling receptors in bone marrow-derived hematopoietic stem/progenitor cell and mesenchymal stromal cell populations., PMID:24405801
Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3 weeks after single-dose MDMA administration in Dark Agouti rats., PMID:24378229
Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs., PMID:23805279
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy., PMID:23776197
Rare autosomal copy number variations in early-onset familial Alzheimer's disease., PMID:23752245
Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping., PMID:21753007
Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells., PMID:21672356