Catalog No.
ACN58301
Biological activity
Measured by its ability to cause heart reversals when injected into the right lateral plate of a population of Xenopus neurulae embryos. 80 ng per embryo induces 25-50% heartreversals.
Measured by its binding ability in a functional ELISA. Immobilized rchCAR/Caronte (Cat #: ACN58301) at 5µg/mL (100 µL/well) can bind hBMP-4 with a linear range of 0.8-100 ng/mL.
Expression system
Mammalian Cells
Species
Gallus gallus (Chicken)
Protein length
Asp16-Asn272
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9PUK2
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAR, Caronte
γδ T cells induced by zoledronate under macrophage-depleted conditions reduce disease severity and parasite number in Eimeria tenella-infected chicks., PMID:40450955
HSP90 Enhances Mitophagy to Improve the Resistance of Car-Diomyocytes to Heat Stress in Wenchang Chickens., PMID:39519247
Chick Embryo Chorioallantoic Membrane as a Platform for Assessing the In Vivo Efficacy of Chimeric Antigen Receptor T-cell Therapy in Solid Tumors., PMID:39225630
Cadmium causes spleen toxicity in chickens by regulating mitochondrial unfolded protein response and nuclear receptors response., PMID:39180780
Protective Effects of Astaxanthin on Ochratoxin A-Induced Liver Injury: Effects of Endoplasmic Reticulum Stress and Mitochondrial Fission-Fusion Balance., PMID:38393146
Variation in the affinity of three representative avian adenoviruses for the cellular coxsackievirus and adenovirus receptor., PMID:38374082
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study., PMID:38066564
The antioxidative influence of dietary creatine monohydrate and L-carnitine on laying performance, egg quality, ileal microbiota, blood biochemistry, and redox status of stressed laying quails., PMID:37939584
Development of fish gelatin/carrageenan/zein bio-nanocomposite active-films incorporated with turmeric essential oil and their application in chicken meat preservation., PMID:37119724
Resveratrol protects against cadmium-induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes., PMID:37115015
Chicken xenobiotic receptor upregulates the BCRP/ABCG2 transporter., PMID:36402040
Chicken-derived CD20 antibodies with potent B-cell depletion activity., PMID:36039695
Comparison of antagonistic effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR/PXR/Nrf2 pathways activation., PMID:35331899
Beneficial impact of dietary methyl methionine sulfonium chloride and/or L-carnitine supplementation on growth performance, feed efficiency, and serum biochemical parameters in broiler chicken: role of IGF-1 and MSTN genes., PMID:35141787
Cadmium induced Fak -mediated anoikis activation in kidney via nuclear receptors (AHR/CAR/PXR)-mediated xenobiotic detoxification pathway., PMID:34902763
Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers., PMID:33396089
Carnosine and anserine in chicken can quench toxic acrylamide under cooking conditions: Mass spectrometric studies on adduct formation and characterization., PMID:32688306
Identification of chicken CAR homology as a cellular receptor for the emerging highly pathogenic fowl adenovirus 4 via unique binding mechanism., PMID:32174269
Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated Mitophagy., PMID:32068207
Unravelling the receptor binding property of egg drop syndrome virus (EDSV) from the crystal structure of EDSV fiber head., PMID:31381914
Quantitative assessment of tolerance response to stress after exposure to oregano and rosemary essential oils, carvacrol and 1,8-cineole in Salmonella Enteritidis 86 and its isogenic deletion mutants ∆dps, ∆rpoS and ∆ompR., PMID:31229127
Effect of carvacrol essential oils on immune response and inflammation-related genes expression in broilers challenged by lipopolysaccharide., PMID:30590708
Insights into CYP2B6-mediated drug-drug interactions., PMID:27709010
The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor., PMID:27110634
The Coxsackievirus and Adenovirus Receptor: Glycosylation and the Extracellular D2 Domain Are Not Required for Coxsackievirus B3 Infection., PMID:27030267
Genetic parameters of IgM and IgG antibodies binding autoantigens in healthy chickens., PMID:26706361
A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors., PMID:25787118
Identification of candidate genes and mutations in QTL regions for immune responses in chicken., PMID:25752210
Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective., PMID:25711679
Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers., PMID:25455252
Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor., PMID:24741103
1,2-Dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH)-mediated steroid hormone receptor activation and gene regulation in chicken LMH cells., PMID:24375616
Improved liquid-chromatography tandem mass spectrometry method for the determination of the bioactive dipeptides, carnosine and anserine: application to analysis in chicken broth., PMID:22483913
Carnitine supplementation modulates high dietary copper-induced oxidative toxicity and reduced performance in laying hens., PMID:21710373
Regulation of expression and activity of selenoenzymes by different forms and concentrations of selenium in primary cultured chicken hepatocytes., PMID:20624339
Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans., PMID:19381778
Interferon regulatory factors (IRFs) repress transcription of the chicken ovalbumin gene., PMID:19341784
Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species., PMID:19162173
Identification of HI-like loop in CELO adenovirus fiber for incorporation of receptor binding motifs., PMID:17596306
Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP., PMID:17538635
In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase., PMID:17213310
Cloning and expression analysis of androgen receptor gene in chicken embryogenesis., PMID:16480982
Induction of drug metabolism: the role of nuclear receptors., PMID:14657421
Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor., PMID:12896978
Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors., PMID:12486395
BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo., PMID:12091312
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors., PMID:11981033
Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit., PMID:11867618
The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes., PMID:11455014
Chick CFC controls Lefty1 expression in the embryonic midline and nodal expression in the lateral plate., PMID:11397007
For research use only. Not for human or drug use.
