Catalog No.
AHN20401
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human NLGN3 (Cat #: AHN20401) is immobilized at 2 μg/mL, biotinylated recombinant human Neurexin 1 beta binds with a typical ED50 = 150-900 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala39-Ser709 (Ser92Tyr)
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZ94
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NL3, Gliotactin homolog, NLGN3, KIAA1480, Neuroligin-3
What are the levels and interactions of neuroligin-1, neuroligin-3, and inflammatory cytokines (IL-6, IL-8) in children diagnosed with autism spectrum disorder?, PMID:39875012
Analyses of Human Genetic Data to Identify Clinically Relevant Domains of Neuroligins., PMID:39766868
Adult neurogenesis in the ventral hippocampus decreased among animal models of neurodevelopmental disorders., PMID:39764171
Corrigendum: Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes., PMID:39726846
Prenatal THC exposure drives sex-specific alterations in spatial memory and hippocampal excitatory/inhibitory balance in adolescent rats., PMID:39571245
Conserved autism-associated genes tune social feeding behavior in C. elegans., PMID:39468047
Attenuated responses to attention-modulating drugs in the neuroligin-3R451C mouse model of autism., PMID:39092656
Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number., PMID:39003414
Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes., PMID:38977697
Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes., PMID:38752179
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance., PMID:38475840
Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation., PMID:38272450
Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3R451C Mouse Model of Autism., PMID:38255906
Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis., PMID:38254206
Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling., PMID:37880221
Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept., PMID:37842184
Neuroligin-3 activates Akt-dependent Nrf2 cascade to protect osteoblasts from oxidative stress., PMID:37774803
Altered Epigenetic Marks and Gene Expression in Fetal Brain, and Postnatal Behavioural Disorders, Following Prenatal Exposure of Ogg1 Knockout Mice to Saline or Ethanol., PMID:37759530
Regulation of NLGN3 and the Synaptic Rho-GEF Signaling Pathway by CDK5., PMID:37699715
Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3R451C mouse model of autism., PMID:37542090
Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal-Glial Synapses and Reduced Expression in Nlgn3R451C Mice., PMID:37509099
Targeting Wnt/β-catenin-mediated upregulation of oncogenic NLGN3 suppresses cancer stem cells in glioblastoma., PMID:37443071
Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency., PMID:36810932
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3., PMID:36635704
The Emerging Role of the Gut-Brain-Microbiota Axis in Neurodevelopmental Disorders., PMID:36587154
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism., PMID:36280753
Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression., PMID:35955861
Behavioral manifestations in rodent models of autism spectrum disorder: protocol for a systematic review and network meta-analysis., PMID:35883206
Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism., PMID:35850732
Gender differences in effects of prenatal and postnatal exposure to electromagnetic field and prenatal zinc on behaviour and synaptic proteins in rats., PMID:35364275
Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma., PMID:35148403
Quantification of the trans-synaptic partners neurexin-neuroligin in CSF of neurodegenerative diseases by parallel reaction monitoring mass spectrometry., PMID:34990894
Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo., PMID:34845591
Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction., PMID:34690695
Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring., PMID:34575826
Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size., PMID:34542148
Neuronal-driven glioma growth requires Gαi1 and Gαi3., PMID:34373757
An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum., PMID:34262438
NF1 mutation drives neuronal activity-dependent initiation of optic glioma., PMID:34040258
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice., PMID:33758193
Integrative Analysis Identified Key Schizophrenia Risk Factors from an Abnormal Behavior Mouse Gene Set., PMID:33672431
Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus., PMID:33355091
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2., PMID:33347690
Spontaneous motor-behavior abnormalities in two Drosophila models of neurodevelopmental disorders., PMID:33164597
Neuroligins and Neurodevelopmental Disorders: X-Linked Genetics., PMID:32848696
Rescue of oxytocin response and social behaviour in a mouse model of autism., PMID:32760004
Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus., PMID:32381505
Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells., PMID:32372724
Altered Caecal Neuroimmune Interactions in the Neuroligin-3R451C Mouse Model of Autism., PMID:32327975
Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference., PMID:31827744
For research use only. Not for human or drug use.
