Catalog No.
AHJ61001
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human CD248/TEM1 (Cat #: AHJ61001) is immobilized at 2 μg/mL (100 μL/well), the concentration of recombinant human Galectin‑3BP/MAC‑2BP that produces 50% of the optimal binding response is approximately 0.08-0.4 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln18-Arg685
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HCU0
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
Mesangial angiogenesis and interstitial eosinophilic infiltration in diabetic nephropathy are associated with elevated CD248 expression., PMID:40451785
CD248 deficiency promotes angiotensin II-induced aortic lesion by attenuating receptor stability in smooth muscle cells., PMID:40415469
A bioinformatics-driven approach to identify biomarkers and elucidate the pathogenesis of type 2 diabetes concurrent with pulmonary tuberculosis., PMID:40374744
Endosialin-directed CAR-T cell therapy: A promising approach for targeting triple-negative breast cancer., PMID:40318845
Pan-cancer analysis identified CD248 as a potential target for multiple tumor types., PMID:40276611
Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells., PMID:40148545
Histological signatures map anti-fibrotic factors in mouse and human lungs., PMID:40108456
Cd248a regulates pericyte development and viability in zebrafish., PMID:40097701
Expression of tumor endothelial marker 1 in cardiac fibroblast contributes to atrial fibrosis in atrial fibrillation., PMID:40082498
Genome-wide DNA methylation regulation analysis provides novel insights on post-radiation breast cancer., PMID:39955415
Corrigendum to "CD248 induces a maladaptive unfolded protein response in diabetic kidney disease." Kidney International 2023;103:304-319., PMID:39577997
CD248 Cleaved Form in Human Colorectal Cancer Stroma: Implications for Tumor Behavior and Prognosis., PMID:39542103
Deciphering the Dysregulating IGF-1-SP1-CD248 Pathway in Fibroblast Functionality during Diabetic Wound Healing., PMID:39293711
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration., PMID:39260826
CD248-expressing cancer-associated fibroblasts induce non-small cell lung cancer metastasis via Hippo pathway-mediated extracellular matrix stiffness., PMID:39164826
Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm., PMID:39113704
CD248 interacts with ECM to promote hypertrophic scar formation and development., PMID:38944165
Transcriptomic Analyses Reveal the Effects of Walnut Kernel Cake on Adipose Deposition in Pigs., PMID:38927603
CD248-expressing cancer-associated fibroblasts induce epithelial-mesenchymal transition of non-small cell lung cancer via inducing M2-polarized macrophages., PMID:38906929
Stromal Rigidity Stress Accelerates Pancreatic Intraepithelial Neoplasia Progression and Chromosomal Instability via Nuclear Protein Tyrosine Kinase 2 Localization., PMID:38631549
Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing., PMID:38508093
Group XIV C-type lectins: emerging targets in tumor angiogenesis., PMID:38468017
Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis., PMID:38413223
IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer., PMID:38396325
TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts., PMID:38254097
High plasma levels of endosialin and cardiovascular events in patients undergoing coronary angiography., PMID:38189922
Endosialin in Cancer: Expression Patterns, Mechanistic Insights, and Therapeutic Approaches., PMID:38164138
[Expression of endosialin in human hypertrophic scars and its regulation on fibroblast phenotype]., PMID:38129304
BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development., PMID:38101413
Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor., PMID:38087190
CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation., PMID:38061240
[IgG78-DM1 inhibits pulmonary fibrosis by targeting and killing CD248-positive myofibroblasts in mice]., PMID:37732571
Inflammatory Mesenchymal Stem Cells Express Abundant Membrane-Bound and Soluble Forms of C-Type Lectin-like CD248., PMID:37298499
Smoking during pregnancy is associated with the placental proteome., PMID:37209868
Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome., PMID:37115796
CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation., PMID:36997926
CD248 Regulates Inflammation and Encapsulation in Silicone-Related Capsule Formation., PMID:36988436
Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles., PMID:36714146
Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8+ T cells in clear cell renal cell carcinoma., PMID:36646951
Soluble tumor endothelial marker 1 in heart failure with reduced ejection fraction: A pilot study., PMID:36588577
Deciphering the Antifibrotic Property of Metformin., PMID:36552855
Interference in melanoma CD248 function reduces vascular mimicry and metastasis., PMID:36401329
CD248 induces a maladaptive unfolded protein response in diabetic kidney disease., PMID:36309126
Cd248a and Cd248b in zebrafish participate in innate immune responses., PMID:36119065
CXCL12 derived from CD248-expressing cancer-associated fibroblasts mediates M2-polarized macrophages to promote nonsmall cell lung cancer progression., PMID:35985448
CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer., PMID:35950912
Fibroblast expression of CD248 may contribute to exacerbation of microvascular damage during systemic sclerosis., PMID:35916713
TMT-based quantitative proteomics analysis and potential serum protein biomarkers for systemic lupus erythematosus., PMID:35810799
Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling., PMID:35732643
No Significant Association Between Plasma Endosialin Levels and the Presence or Severity of Coronary Artery Disease., PMID:35720228
For research use only. Not for human or drug use.
