Catalog No.
AHK27201
Biological activity
Immobilized human TSLP (R127A, R130A) at 1μg/ml (100μl/Well). Dose response curve for human TSLPR/CRLF2 (Cat #: AHK27201) with the EC50 of 15.5ng/ml.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly25-Lys231
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HC73
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytokine receptor-like 2, CRLF2, CRL2, Thymic stromal lymphopoietin protein receptor, Cytokine receptor-like factor 2, TSLPR, ILXR, IL-XR, TSLP receptor
Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model., PMID:40443683
PM2.5 Stimulates Macrophage-Derived Thymic Stromal Lymphopoietin (TSLP) to Induce a Mouse Model of Allergic Conjunctivitis., PMID:40191989
Triclosan exacerbates atopic dermatitis in mouse models via thymic stromal lymphopoietin., PMID:40059030
TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps., PMID:39940994
Targeting alarmins in asthma: From bench to clinic., PMID:39855362
TSLP and TSLPr Expression and Localization in the Airways of COPD and Non-COPD Patients., PMID:39821119
TSLP acts on regulatory T cells to maintain their identity and limit allergic inflammation., PMID:39792638
Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction., PMID:39703503
Structure-based design and disulfide stapling of interfacial cyclic peptidic inhibitors from thymic stromal lymphopoietin (TSLP) receptor to competitively target TSLP., PMID:39571720
Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis., PMID:39524451
Expression of Epithelial Alarmin Receptor on Innate Lymphoid Cells Type 2 in Eosinophilic Chronic Obstructive Pulmonary Disease., PMID:39452061
CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL., PMID:39420220
Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells., PMID:39373526
Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP/TSLPR/pSTAT5 signals., PMID:39277019
Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy., PMID:38892164
Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases., PMID:38877290
Formononetin protects against Aspergillus fumigatus Keratitis: Targeting inflammation and fungal load., PMID:38593508
Epidermal keratinocyte-specific STAT3 deficiency aggravated atopic dermatitis-like skin inflammation in mice through TSLP upregulation., PMID:38053996
EFFECT OF ANTI-TSLPR MONOCLONAL ANTIBODY ON VIABILITY, PROAPOPTOTIC GENES EXPRESSION, AND PRODUCTION OF PRO-INFLAMMATORY CYTOKINES IN MCF-7 AND A549 CELLS., PMID:37824770
Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL., PMID:37634013
Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma., PMID:37628907
Gain of chromosome 21 increases the propensity for P2RY8::CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression., PMID:37483494
Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth., PMID:37422429
TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts., PMID:37364323
'Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting., PMID:37156894
Severe asthma ILC2s demonstrate enhanced proliferation that is modified by biologics., PMID:37114915
Thymic stromal lymphopoietin rather than IL-33 drives food allergy after epicutaneous sensitization to food allergen., PMID:36878383
Correlation of the surface expression of thymic stromal lymphopoietin receptor with the presence of CRLF2 gene rearrangements in children with B-lineage acute lymphoblastic leukemia., PMID:36748719
B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling., PMID:36608149
Thymic stromal lymphopoietin induces platelet mitophagy and promotes thrombosis in Kawasaki disease., PMID:36341698
Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response., PMID:36311787
Linalyl Acetate Ameliorates Mechanical Hyperalgesia Through Suppressing Inflammation by TSLP/IL-33 Signaling., PMID:36287299
Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment., PMID:36107619
The potential role of interleukin (IL)-25/IL-33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis., PMID:36082495
TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease., PMID:36076269
Nonylphenol exacerbates ovalbumin-induced allergic rhinitis via the TSLP-TSLPR/IL-7R pathway and JAK1/2-STAT3 signaling in a mouse model., PMID:36029577
TSLP protects against sepsis-induced liver injury by inducing autophagy via activation of the PI3K/Akt/STAT3 pathway., PMID:35751928
Potential genetic biomarker of Saudi Arabian patients with colorectal cancer., PMID:35587061
Emerging role for thymic stromal lymphopoietin-responsive regulatory T cells in colorectal cancer progression in humans and mice., PMID:35584230
Thymic stromal lymphopoietin (TSLP) is a potent pro-inflammatory mediator which is epigenetically deregulated in endometriosis., PMID:35381481
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin., PMID:35351157
Thymic stromal lymphopoietin controls hair growth., PMID:35216683
The autoimmune encephalitis-related cytokine TSLP in the brain primes neuroinflammation by activating the JAK2-NLRP3 axis., PMID:35020848
Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response., PMID:34763990
ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases., PMID:34728559
Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism., PMID:34659250
Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression., PMID:34573368
Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors., PMID:34443392
Human Lung-Resident Macrophages Express and Are Targets of Thymic Stromal Lymphopoietin in the Tumor Microenvironment., PMID:34440780
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion., PMID:34326208
For research use only. Not for human or drug use.
