Catalog No.
AHN41801
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human EDAA2/Ectodysplasin A2 is immobilized at 1 µg/mL (100 µL/well), recombinant human EDA2R (Cat #: AHN41801) binds with an ED50 of 40.0-500 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Glu136
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HAV5
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EDA-A2 receptor, XEDAR, EDA2R, TNFRSF27, X-linked ectodysplasin-A2 receptor, Tumor necrosis factor receptor superfamily member 27
Plasma Proteomics Reveals Dysregulated Pathways Across the Spectrum LMNA Cardiomyopathy., PMID:40509996
Exploratory Study of Prognostic Plasma Biomarkers in Patients with Pulmonary Arterial Hypertension., PMID:40451321
Unraveling the role of proteins in dementia: insights from two UK cohorts with causal evidence., PMID:40092369
Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses., PMID:39988718
[Research progress on molecular mechanism related to skeletal muscle atrophy]., PMID:39780580
Large-Scale Plasma Proteomics Improves Prediction of Peripheral Artery Disease in Individuals With Type 2 Diabetes: A Prospective Cohort Study., PMID:39749935
Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity., PMID:39075931
Proteomics profiling and association with cardiorenal complications in type 2 diabetes subtypes in Asian population., PMID:39059739
Tumour-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism., PMID:39001644
Protein biomarker signature in patients with spinal and bulbar muscular atrophy., PMID:38973610
Expression of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) Candidate Genes EDA2R, PCDH9, and TRAF7 in Normal Human Kidney Development and CAKUT., PMID:38927638
Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization., PMID:38883777
EDA2R-NIK signaling in cancer cachexia., PMID:38801457
Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway., PMID:38797667
Exploratory study of blood biomarkers in patients with post-stroke epilepsy., PMID:38557165
Ectodysplasin A2 receptor signaling in skeletal muscle pathophysiology., PMID:38443222
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements., PMID:38233393
Transcription factor FoxO1 regulates myoepithelial cell diversity and growth., PMID:38212454
Microarray analysis of hub genes, non-coding RNAs and pathways in lung after whole body irradiation in a mouse model., PMID:37212632
EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia., PMID:37165186
High-throughput proteomic analysis reveals systemic dysregulation in virally suppressed people living with HIV., PMID:37079385
Molecular Profiling of Inflammatory Processes in a Mouse Model of IC/BPS: From the Complete Transcriptome to Major Sex-Related Histological Features of the Urinary Bladder., PMID:36982831
Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight/obesity and metabolic syndrome., PMID:36964401
Microarray analysis identifies coding and non-coding RNA markers of liver injury in whole body irradiated mice., PMID:36604457
Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease., PMID:36263181
Knockdown of EDA2R alleviates hyperoxia-induced lung epithelial cell injury by inhibiting NF-κB pathway., PMID:36086968
Single-Nucleus Transcriptional Profiling of Chronic Kidney Disease after Cisplatin Nephrotoxicity., PMID:35092726
Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases., PMID:34938205
Understanding the impact of missense mutations on the structure and function of the EDA gene in X-linked hypohidrotic ectodermal dysplasia: A bioinformatics approach., PMID:34817077
Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra., PMID:34103547
Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology., PMID:33981223
Tumor Suppressor Gene XEDAR Promotes Differentiation and Suppresses Proliferation and Migration of Gastric Cancer Cells Through Upregulating the RELA/LXRα Axis and Deactivating the Wnt/β-Catenin Pathway., PMID:33637015
Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice., PMID:33594251
Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor., PMID:32736705
EDA2R mediates podocyte injury in high glucose milieu., PMID:32304771
RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis., PMID:31885785
XEDAR inhibits the proliferation and induces apoptosis of gastric cancer cells by regulating JNK signaling pathway., PMID:31829409
Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice., PMID:31607478
Studies on sporadic non-syndromic thoracic aortic aneurysms: II. Alterations of extra-cellular matrix components and focal adhesion proteins., PMID:29708036
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma., PMID:29338018
Androgenetic alopecia: a review., PMID:28349362
Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia., PMID:28106506
Mutational spectrum in 101 patients with hypohidrotic ectodermal dysplasia and breakpoint mapping in independent cases of rare genomic rearrangements., PMID:27305980
Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia., PMID:27060448
Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing., PMID:26814133
X-linked ectodermal dysplasia receptor (XEDAR) gene silencing prevents caspase-3-mediated apoptosis in Sjögren's syndrome., PMID:26659383
Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses., PMID:26589571
XEDAR activates the non-canonical NF-κB pathway., PMID:26260321
Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss., PMID:24352509
Genetic variants at 20p11 confer risk to androgenetic alopecia in the Chinese Han population., PMID:23990985
For research use only. Not for human or drug use.
