Catalog No.
AHJ99001
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of mouse vascular endothelial cells (SVEC4‑10). When 4 x 10^4 cells/well are added to recombinant human CLMP/ASAM (Cat #: AHJ99001) coated plates (30 µg/mL, 100 µL/well), approximately 25%‑50% will adhere after one hour at 37 ℃.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly18-Met233
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H6B4
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CLMP, ACAM, CAR-like membrane protein, Adipocyte adhesion molecule, CXADR-like membrane protein, Coxsackie- and adenovirus receptor-like membrane protein, ASAM
CLMP increases 5-fluorouracil sensitivity in colorectal cancer through the inhibition of autophagy., PMID:39922002
Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts of Physical Activity and its Protective Role Against Dementia., PMID:39867359
Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development., PMID:39763071
Coxsackievirus and adenovirus receptor expression facilitates enteroviral infections to drive the development of pancreatic cancer., PMID:39627248
Exploring susceptibility and therapeutic targets for kidney stones through proteome-wide Mendelian randomization., PMID:39530187
Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral Entry., PMID:39339932
Liver-specific Coxsackievirus and adenovirus receptor deletion develop metabolic dysfunction-associated fatty liver disease., PMID:39285218
CAR expression in invasive breast carcinoma and its effect on adenovirus transduction efficiency., PMID:39256827
Congenital short bowel syndrome: Cases series in the same family and review of literature., PMID:39173431
CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling., PMID:38146657
CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer., PMID:37944525
CXADR-Like Membrane Protein Regulates Colonic Epithelial Cell Proliferation and Prevents Tumor Growth., PMID:37716376
Identification of fibroblast-related genes based on single-cell and machine learning to predict the prognosis and endocrine metabolism of pancreatic cancer., PMID:37588985
The IgSF Cell Adhesion Protein CLMP and Congenital Short Bowel Syndrome (CSBS)., PMID:36982793
CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis., PMID:36241608
Congenital Short-Bowel Syndrome Is Associated With a Novel Deletion Mutation in the CLMP Gene: Mutations in CLMP Caused CSBS., PMID:35111702
JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy., PMID:34427588
Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis., PMID:34127684
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor., PMID:33762416
Congenital Short-Bowel Syndrome: Clinical and Genetic Presentation in China., PMID:33464596
Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice., PMID:33408624
Whole-Exome Sequencing Identified Novel CLMP Mutations in a Family With Congenital Short Bowel Syndrome Presenting Differently in Two Probands., PMID:33384711
The CAR group of Ig cell adhesion proteins-Regulators of gap junctions?, PMID:33174233
CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction., PMID:33084169
Analyzing and validating the prognostic value and mechanism of colon cancer immune microenvironment., PMID:32859214
Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques., PMID:32852032
The coxsackievirus and adenovirus receptor: virological and biological beauty., PMID:32298477
Congenital short bowel syndrome: systematic review of a rare condition., PMID:32278545
Identification of novel human adenovirus candidates using the coxsackievirus and adenovirus receptor for cell entry., PMID:32272960
Transduction Efficiency of Adenovirus Vectors in Endothelial Cells and Vascular Smooth Muscle Cells., PMID:32168154
Skin barrier damage after exposure to paraphenylenediamine., PMID:31783056
Clues From Ultrasound for an Infant With Failure to Thrive., PMID:31589836
Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance., PMID:31465819
The Cxadr-Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice., PMID:31373105
External validation of molecular subtype classifications of colorectal cancer based on microsatellite instability, CIMP, BRAF and KRAS., PMID:31296182
Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism., PMID:31163079
CEACAM-1 promotes myocardial injury following coxsackievirus infection by regulating the coxsackievirus-adenovirus receptor., PMID:31083261
First Report of Congenital Short Bowel Syndrome in an Iranian Patient Caused by a Mutation in the CLMP Gene., PMID:31061750
Relationship between Cell Receptors and Tumor Cell Sensitivity to Oncolytic Enteroviruses., PMID:30450519
CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer., PMID:30385615
The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice., PMID:29361518
Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum., PMID:28381574
Influence of Hierarchical Interfacial Assembly on Lipase Stability and Performance in Deep Eutectic Solvent., PMID:28215070
A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo., PMID:28074864
Cell-cell communication mediated by the CAR subgroup of immunoglobulin cell adhesion molecules in health and disease., PMID:27871939
Two new mutations of the CLMP gene identified in a newborn presenting congenital short-bowel syndrome., PMID:27720179
Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity., PMID:27629708
Regulation of the Coxsackie and adenovirus receptor expression is dependent on cystic fibrosis transmembrane regulator in airway epithelial cells., PMID:27527752
Genetic screening of Congenital Short Bowel Syndrome patients confirms CLMP as the major gene involved in the recessive form of this disorder., PMID:27352967
Coxsackievirus and Adenovirus Receptor, a Tight Junction Protein, in Peri-Implantation Mouse Embryos., PMID:27226313
For research use only. Not for human or drug use.
