Catalog No.
AHJ53401
Biological activity
Measured in a cell proliferation assay using mouse pro‑B cells (BaF3) transfected with human FGF RIIIc. The ED50 for this effect is 0.1‑0.4 µg/mL in the presence of recombinant Mouse Klotho and heparin.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Tyr25-Ile251
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9GZV9
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphatonin, FGF-23, HYPF, FGF23, Fibroblast growth factor 23, Tumor-derived hypophosphatemia-inducing factor
Klotho promotes bone formation in rheumatoid arthritis-associated osteoporosis by modulating the Fgf23/Fgfr1/NF-κB pathway and inhibiting ferroptosis., PMID:40513341
Association of atrial fibrillation burden and clinical profile with blood biomarkers: Results from the ISOLATION Ablation Cohort., PMID:40496590
Use of burosumab in McCune Albright syndrome: case report and review of literature in mosaic disorders with FGF23 overproduction., PMID:40491596
Hepatic transcriptome profiling unveils candidate genes in cattle with liver abscesses under the influence of beef genetics in dairy cattle., PMID:40489480
Exploring the Role of FGF7 in Tumor-Induced Osteomalacia. Clinic-Pathologic Analysis in a Patient with a Sino-Nasal Phosphaturic Mesenchymal Tumor., PMID:40488899
High fat diet induces gastric production of fibroblast growth factor 23 (FGF23)., PMID:40483378
High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation Through Central Fibroblast Growth Factor Receptor Signaling., PMID:40469026
Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population., PMID:40464156
Bone mineralization and the effects of elevated osteopontin: from symmetry-breaking foci to 3D space-filling tessellation., PMID:40439195
Assessment of bone status and bone turnover in pediatric patients with familiar hypomagnesemia with hypercalciuria and nephrocalcinosis., PMID:40425732
Plasma inflammation-related proteins associated with anxiety and depression disorders in IBD patients., PMID:40419679
Diagnostic potential of increased Klotho and FGF23 protein concentrations after myocardial infarction in patients with acute coronary syndrome., PMID:40417994
Tumour-induced osteomalacia due to a rare intrathoracic phosphaturic mesenchymal tumour., PMID:40409766
Hormonal and mineral dysregulation determine the dynamics of calcification in adenine-induced CKD in male rats., PMID:40396885
FGF-23 and Long-term Outcome in Peripheral Artery Disease., PMID:40394833
Crosstalk between kidney and bones: New perspective for modulating osteoporosis., PMID:40389172
Burosumab treatment of tumour-induced osteomalacia from a rib lesion., PMID:40379296
Causal relationship between molecular markers of biological aging and orthopedic diseases: A two-sample bidirectional Mendelian randomization study., PMID:40373834
Klotho plasma levels are an independent predictorof mortality in women with acute coronary syndrome., PMID:40369094
Diagnostic and Prognostic Evaluation of Novel Biomarkers Compared to ESC 0/1 h and 0/3 h Algorithms in Patients with Suspected Non-ST-Elevation Myocardial Infarction., PMID:40363990
Hyperphosphatemia in Kidney Failure: Pathophysiology, Challenges, and Critical Role of Phosphorus Management., PMID:40362897
Non-Oxidised Parathyroid Hormone and a Panel of Markers of Calcium-Phosphate Metabolism for Analysis of Secondary Hyperparathyroidism in Selected Patient Groups-A Quality Assurance Project., PMID:40362516
Updates on renal phosphate transport., PMID:40357590
Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study., PMID:40325450
The roles and signalling pathways of lncMALAT1 in coronary artery disease: A protocol for systematic review of in vivo and in vitro studies., PMID:40323939
Thromboxane A2 or activated platelets slightly low-er Fgf23 expression in vitro., PMID:40319868
Risk factors for coronary artery calcification in Chinese patients undergoing maintenance hemodialysis: a meta-analysis., PMID:40314886
Effects of aging on chronic kidney disease mineral and bone disorder., PMID:40314085
Cellular communication networks in fibrosis: Insights from the MASLD pig model., PMID:40304567
A Child with Cutaneous-Skeletal Hypophosphatemia Syndrome Caused by a Mosaic HRAS Mutation: Outcome of Treatment with Anti-FGF23 Antibody., PMID:40295341
The Diagnosis and Therapy of XLH., PMID:40295317
The Critical Role of Vitamin D Supplementation for Skeletal and Neurodevelopmental Outcomes in Preterm Neonates., PMID:40284243
The Roxadustat (FG-4592) ameliorates tubulointerstitial fibrosis by promoting intact FGF23 cleavage., PMID:40281613
Metabolism-related hepatokines change in biliary atresia: ANGPTL6 as a potential biomarker., PMID:40281461
Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications., PMID:40279260
Gαq/11 Signaling Modulates Fibroblast Growth Factor 23 Production and Contributes to Acute Kidney Injury., PMID:40275688
Advancing patient evidence in XLH (APEX): rationale and design of a real-world XLH global data unification program., PMID:40260280
A Randomised Prospective Crossover Study on the Effects of Medium Cut-Off Membranes on FGF-23 and Inflammatory Mediators in Patients Receiving Regular Haemodialysis., PMID:40258362
Fibroblast growth factor (FGF) 23 and FGF receptor 4 induced cardiac mitochondrial dysfunction as a new target in CKD?, PMID:40254356
Fibroblast growth factor 23 as a risk factor for incident diabetes., PMID:40237064
Biomarker and cognitive decline in atrial fibrillation: a prospective cohort study., PMID:40234472
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways., PMID:40229627
Case report: Reversible Fanconi syndrome due to vitamin D deficiency in a patient with epilepsy harbouring a pathogenic variant in the SLC34A1 gene., PMID:40225330
Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis., PMID:40220947
Development of animal models with chronic kidney disease-mineral and bone disorder based on clinical characteristics and pathogenesis., PMID:40201764
Vascular calcification inhibitors in chronic kidney disease., PMID:40185382
The role of osteopontin in chronic kidney disease-mineral bone disorder., PMID:40166833
Tumor-induced rickets/osteomalacia (TIO): diagnostic pitfalls and therapeutic options., PMID:40156290
Fibroblast growth factor 23 neutralizing antibody partially rescues bone loss and increases hematocrit in sickle cell disease mice., PMID:40155665
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?, PMID:40152642
For research use only. Not for human or drug use.
