Catalog No.
AHK98201
Biological activity
Measured by its ability to bind rrMAG in a functional ELISA.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Cys27-Ser447
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BZR6
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NgR, Nogo receptor, Reticulon-4 receptor, RTN4R, Nogo-66 receptor, NOGOR
Characterization of the N-terminal region of Crtac1B/LOTUS, an endogenous Nogo receptor-1 antagonist, required for secretion and soluble function., PMID:40494480
NgR1 knockout increased neuronal excitability and altered seizure pattern in traumatic brain injury mice brain after PTZ-induced seizure., PMID:40233041
Antibodies targeting ADAM17 reverse neurite outgrowth inhibition by myelin-associated inhibitors., PMID:40132887
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
Hippocampal Nogo66-NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disorders., PMID:39412367
Viral capsid structural assembly governs the reovirus binding interface to NgR1., PMID:39347978
Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through Its Interaction with Teneurin-4., PMID:39195260
Behavioral stress and antidepressant treatments altered hippocampal expression of Nogo signal-related proteins in rats., PMID:38157668
Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice., PMID:38097540
Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a Novel Drug Target., PMID:37958606
Development of neural repair therapy for chronic spinal cord trauma: soluble Nogo receptor decoy from discovery to clinical trial., PMID:37865850
Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation., PMID:37449592
How does Nogo receptor influence demyelination and remyelination in the context of multiple sclerosis?, PMID:37361998
NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein., PMID:37276413
Identification of biomarkers for glycaemic deterioration in type 2 diabetes., PMID:37137910
Nogo receptor-Fc delivered by haematopoietic cells enhances neurorepair in a multiple sclerosis model., PMID:37091588
Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice., PMID:36961417
Molecular Characterization and Function of the Nogo-66 Receptor (NgR1) Gene in the Chinese Tree Shrew., PMID:36722229
A check on the immunological synapse., PMID:36649376
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse., PMID:36624164
Shenfu Injection Protects Brain Injury in Rats with Cardiac Arrest through Nogo/NgR Pathway., PMID:36600931
Glucopeptides derived from myelin-relevant proteins and hyperglucosylated nontypeable Haemophilus influenzae bacterial adhesin cross-react with multiple sclerosis specific antibodies: A step forward in the identification of native autoantigens in multiple sclerosis., PMID:36597597
Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression., PMID:36448220
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2., PMID:36288715
Augmented Expression of NOGO-A and Its Receptors in Human Retinal Pigment Epithelial Cells Following Treatment with Human Amniotic Fluid., PMID:36248281
Myelin-associated glycoprotein alters the neuronal secretome and stimulates the release of TGFβ and proteins that affect neural plasticity., PMID:36102862
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma., PMID:35886008
[Fasudil reduces apoptosis of SH-SY5Y cells induced by H2O2 and promotes synaptic plasticity by inhibiting neurite outgrowth inhibitor A and its receptor (NogoA/NgR) signaling pathway]., PMID:35786457
Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes., PMID:35618095
The Nogo-66 Receptors NgR1 and NgR3 Are Required for Commissural Axon Pathfinding., PMID:35437280
The Murine Neuronal Receptor NgR1 Is Dispensable for Reovirus Pathogenesis., PMID:35353001
Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization., PMID:35323639
RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction., PMID:35263212
Notoginsenoside R1 relieves the myocardial infarction via activating the JAK2/STAT3 signaling pathway in vivo and in vitro., PMID:35263202
Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma., PMID:35135857
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis., PMID:35092824
Novel contributors to B cell activation during inflammatory CNS demyelination; An oNGOing process., PMID:34975310
A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development., PMID:34848542
RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development., PMID:34758294
Anti-LINGO-1 improved remyelination and neurobehavioral deficit in cuprizone-induced demyelination., PMID:34712419
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury., PMID:34653401
NEP1‑40 promotes myelin regeneration via upregulation of GAP‑43 and MAP‑2 expression after focal cerebral ischemia in rats., PMID:34643252
NgR1 pathway expression in cerebral ischemic Sprague-Dawley rats with cognitive impairment., PMID:34630954
An in-depth analysis reveals two new genetic variants on 22q11.2 associated with vitiligo in the Chinese Han population., PMID:34350550
A Novel Role of Nogo Proteins: Regulating Macrophages in Inflammatory Disease., PMID:34224050
Go, cancer stem cell, go! CSCs overcome myelin inhibition to move within white matter pathways., PMID:33693693
LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation., PMID:33658590
Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice., PMID:33551743
B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF., PMID:33536561
Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation., PMID:33495810
For research use only. Not for human or drug use.
