Catalog No.
AHN57701
Biological activity
When recombinant human NKG2D/CD314 is immobilized at 2 µg/mL (100 µL/well), recombinant human ULBP3 (Cat #: AHN57701) His-tag binds with an ED50 of 0.100-1.20 µg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly27-Pro216
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BZM4
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NKG2DL3, N2DL3, RAET1N, UL16-binding protein 3, N2DL-3, ULBP3, NKG2D ligand 3, ALCAN-gamma, Retinoic acid early transcript 1N
The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling., PMID:39963517
B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies., PMID:39579618
UL16‑binding protein 1 is a significant prognostic and diagnostic marker for breast cancer., PMID:39492940
The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation., PMID:38953028
Unveiling the role of the KLF4/Lnc18q22.2/ULBP3 axis in the tumorigenesis and immune escape of hepatocellular carcinoma under hypoxic condition., PMID:38780505
Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease., PMID:38410511
CLPTM1L is a GPI-anchoring pathway component targeted by HCMV., PMID:37389656
Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing., PMID:37298418
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients., PMID:36741391
A signature based on NKG2D ligands to predict the recurrence of hepatocellular carcinoma after radical resection., PMID:36210637
The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology., PMID:35936986
Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation., PMID:35584138
In vivo efficacy of decitabine as a natural killer cell-mediated immunotherapy against isocitrate dehydrogenase mutant gliomas., PMID:35104792
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition., PMID:34721381
Downregulation of NKG2DLs by TGF-β in human lung cancer cells., PMID:34253166
Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma., PMID:33909599
Genetic Variability of Human Cytomegalovirus Clinical Isolates Correlates With Altered Expression of Natural Killer Cell-Activating Ligands and IFN-γ., PMID:33897679
Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study., PMID:33779082
[Effects and Mechanism of PARP Inhibitor Olaparib on the Expression of NKG2D Ligands in HL-60 Cells]., PMID:33283705
Down-regulation of UL16-binding protein 3 mediated by interferon-gamma impairs immune killing in nasopharyngeal carcinoma., PMID:33194048
Celecoxib upregulates ULBP-1 expression in lung cancer cells via the JNK/PI3K signaling pathway and increases susceptibility to natural killer cell cytotoxicity., PMID:33014157
Metabolism of short-chain fatty acid propionate induces surface expression of NKG2D ligands on cancer cells., PMID:32996653
Polymorphisms associated to bovine paratuberculosis: investigation of their role in DNA-protein interactions and transcriptional regulation., PMID:32761582
Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D., PMID:32698530
Expressions of natural cytotoxicity receptor, NKG2D and NKG2D ligands in endometriosis., PMID:31655348
[Influence of Oridonin on the Icilling Acitivity of NK-92 MI Cells Targeting Cell THP1 and Its Mechanism]., PMID:31607286
Symptomatic Carotid Atherosclerotic Plaques Are Associated With Increased Infiltration of Natural Killer (NK) Cells and Higher Serum Levels of NK Activating Receptor Ligands., PMID:31354703
Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients., PMID:31303272
Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma., PMID:31292299
MG132 selectively upregulates MICB through the DNA damage response pathway in A549 cells., PMID:30483783
Combined inhibition of JAK1,2/Stat3‑PD‑L1 signaling pathway suppresses the immune escape of castration‑resistant prostate cancer to NK cells in hypoxia., PMID:29693186
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4⁺ T Cells., PMID:29023371
[Decitabine Enhances the Sensitivity of Leukemia Stem Cell to Allo-NK Cell-Mediated Killing]., PMID:28245380
NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline., PMID:27734028
Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression., PMID:27733551
Human Herpesvirus 6B Downregulates Expression of Activating Ligands during Lytic Infection To Escape Elimination by Natural Killer Cells., PMID:27535049
ULBP3: a marker for alopecia areata incognita., PMID:27142445
IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression., PMID:27116977
Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility., PMID:27002316
Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity., PMID:26992229
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models., PMID:26871660
STAT3 signaling pathway is involved in decitabine induced biological phenotype regulation of acute myeloid leukemia cells., PMID:26692933
Maternal IL-6 can cause T-cell-mediated juvenile alopecia by non-scarring follicular dystrophy in mice., PMID:26660334
[Study of NK cells dysfunction in multiple myeloma patients]., PMID:26632464
Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts., PMID:26361968
Oxaliplatin regulates expression of stress ligands in ovarian cancer cells and modulates their susceptibility to natural killer cell-mediated cytotoxicity., PMID:26138671
Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection., PMID:25995251
Transfer of the human NKG2D ligands UL16 binding proteins (ULBP) 1-3 is related to lytic granule release and leads to ligand retransfer and killing of ULBP-recipient natural killer cells., PMID:25980678
Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids., PMID:25933805
MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer., PMID:25510288
For research use only. Not for human or drug use.
