Catalog No.
AHK97701
Biological activity
Measured by its ability to inhibit the adhesion of human acute lymphoblastic leukemia T lymphocytes (J45.01) on immobilized JAM3 (Cat #: AHK97701). When 0.2 µg/mL (100 µL/well) of rhJAM-B is immobilized on goat anti-human IgG Fc Chimera antibody coated wells, the ED50 for this effect is 0.1-0.5 µg/mL in the presence of 1 x 10^5 cells/well.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Val32-Asn241
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BX67
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
JAM-3, JAM-C, JAM-2, Junctional adhesion molecule 3, Junctional adhesion molecule C, sJAM-C, JAM3
The role of PAX1 and JAM3 methylation in predicting the pathological upgrading of cervical intraepithelial neoplasia before conization., PMID:40399320
Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection., PMID:40313764
The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection., PMID:40204948
Upstream transcription factor 1 suppresses laryngeal squamous cell carcinoma progression through transcriptional activation of junctional adhesion molecule 3., PMID:40071730
Epigenetic silencing of JAM3 promotes laryngeal squamous cell carcinoma development by inhibiting the Hippo pathway., PMID:39749700
Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women., PMID:39726021
High-adhesion ovarian cancer cell resistance to ferroptosis: The activation of NRF2/FSP1 pathway by junctional adhesion molecule JAM3., PMID:39706500
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection., PMID:39696066
Triage performance of DNA methylation for women with high-risk human papillomavirus infection., PMID:39603822
Threonine attenuates lipopolysaccharide-induced intestinal inflammatory responses in rabbits., PMID:39549129
Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US)., PMID:39528979
Computational insights into irinotecan's interaction with UBE2I in ovarian and endometrial cancers., PMID:39476484
Junctional adhesion molecular 3 (JAM3) is a novel tumor suppressor and improves the prognosis in breast cancer brain metastases via the TGF-β/Smad signal pathway., PMID:39320657
Dietary Mulberry leaf 1-deoxynijirimycin supplementation shortens villus height and improves intestinal barrier in fattening rabbits., PMID:39210821
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non‒16/18 human papillomavirus-positive women: a multicenter prospective study in China., PMID:39152491
Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML., PMID:38954834
Dynamic changes in key factors of the blood-brain barrier in early diabetic mice., PMID:38874450
[A multicenter study on the accuracy of PAX1/JAM3 dual genes methylation testing for screening cervical cancer]., PMID:38782754
JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway., PMID:38760803
Expression of genes related to ileal barrier function in heritage and modern broiler chickens., PMID:38717281
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients., PMID:38448375
JAM3: A prognostic biomarker for bladder cancer via epithelial-mesenchymal transition regulation., PMID:38400838
Effects of betaine on growth performance and intestinal health of rabbits fed different digestible energy diets., PMID:38290533
Expression and hypermethylation of JAM and EPB41L3 in cervical squamous cell carcinoma: Clinical significance and applications., PMID:38213260
Downregulation of JAM3 occurs in cholangiocarcinoma by hypermethylation: A potential molecular marker for diagnosis and prognosis., PMID:38124399
JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development., PMID:38095908
Inclusion of Quillaja Saponin Clarity Q Manages Growth Performance, Immune Response, and Nutrient Transport of Broilers during Subclinical Necrotic Enteritis., PMID:37630454
Prognostic significance of JAM 3 in gastric cancer: An observational study from TCGA and GEO., PMID:37115068
Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma., PMID:36990421
The activation of EP300 by F11R leads to EMT and acts as a prognostic factor in triple-negative breast cancers., PMID:36782375
Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma., PMID:36768928
Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling., PMID:36461092
Identification of novel rare copy number variants associated with sporadic tetralogy of Fallot and clinical implications., PMID:35882632
Decreased junctional adhesion molecule 3 expression induces reactive oxygen species production and apoptosis in trophoblasts†., PMID:35871541
miR-127-5p Targets JAM3 to Regulate Ferroptosis, Proliferation, and Metastasis in Malignant Meningioma Cells., PMID:35818586
Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis., PMID:35768842
Tracking the Molecular Scenarios for Tumorigenic Remodeling of Extracellular Matrix Based on Gene Expression Profiling in Equine Skin Neoplasia Models., PMID:35742950
Study on the Mechanism of MicroRNA551b-5p in Severe Acute Pancreatitis Capillary Leakage Syndrome., PMID:35256892
The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia., PMID:35032792
Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins., PMID:35013117
Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3., PMID:35013102
Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans., PMID:34861679
Cancer-associated fibroblasts in colorectal cancer., PMID:34839457
Long-Term Maintenance of Viable Adult Rat Sertoli Cells Able to Establish Testis Barrier Components and Function in Response to Androgens., PMID:34572053
Analyzing normal and disrupted leukemic stem cell adhesion to bone marrow stromal cells by single-molecule tracking nanoscopy., PMID:34435622
Junctional Adhesion Molecule 3 Expression in the Mouse Airway Epithelium Is Linked to Multiciliated Cells., PMID:34395412
Tumor immune microenvironment of primary colorectal adenocarcinomas metastasizing to the liver or lungs., PMID:34351649
A novel homozygous variant in JAM3 gene causing hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts (HDBSCC) with neonatal onset., PMID:34292449
Genome sequencing for detection of pathogenic deep intronic variation: A clinical case report illustrating opportunities and challenges., PMID:34159711
Flow Cytometry Analysis of Mouse Hematopoietic Stem and Multipotent Progenitor Cells., PMID:34057715
For research use only. Not for human or drug use.
