Catalog No.
AHN57601
Biological activity
Measured by its ability to cleave the fluorogenic peptide substrate, SUC-Ala-Ala-ProPhe-AMC. The specific activity is >400 pmol/min/μg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Leu268
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99895
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Caldecrin, CTRC, CLCR, Chymotrypsin-C
Case Study: Genetic and In Silico Analysis of Familial Pancreatitis., PMID:40428425
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD., PMID:40343765
To be, or not to be cleaved: Directed evolution of a canonical serine protease inhibitor against active and inactive protease pair identifies binding loop residue critical for prevention of proteolytic cleavage., PMID:40298105
MicroRNA-486-3p Targets Chymotrypsin C to Regulate Pancreatic Cancer Progression and Immunosuppressive Factor Expression., PMID:39985497
Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV., PMID:39966732
Safety, Tolerability, and Pharmacokinetics of Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC07-523LS in Newborn Infants Exposed to HIV-1., PMID:39821046
Study of a panel of genetic mutations in fibrocalcific pancreatic diabetes (FCPD): SPINK1 (N34S) mutation unlikely to be relevant., PMID:39738564
Histological, histochemical, and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering., PMID:39538248
Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog., PMID:39265662
Conservation of antiviral systems across domains of life reveals immune genes in humans., PMID:39208803
SARS-CoV-2 seropositivity in African women living with HIV and their infants., PMID:38992577
Q&A: Barriers to testing for NTRK fusions in metastatic lung and thyroid cancer., PMID:38953729
Diagnosing NTRK fusions in lung and thyroid cancer., PMID:38953726
Efficacy and safety of NTRK inhibitors in patients with NTRK fusion-positive lung and thyroid cancers., PMID:38953725
A De Novo CaSR Missense Variant in Combination with Two Inherited Missense Variants in CFTR and SPINK1 Detected in a Patient with Chronic Pancreatitis., PMID:38927485
Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases., PMID:38876922
Diagnostic yield of repeat genetic testing in idiopathic chronic pancreatitis., PMID:38657903
Understanding the toxicity mechanism of gelsemine in zebrafish., PMID:38447648
Genetic Factors Associated With Adverse Pregnancy Outcomes in Chronic Pancreatitis., PMID:38334943
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct., PMID:38317495
Acute Fluid Biomarkers for Diagnosis and Prognosis in Children with Mild Traumatic Brain Injury: A Systematic Review., PMID:38133736
Micronutrients and nutritional status among children living with HIV with and without severe acute malnutrition: IMPAACT P1092., PMID:37919816
Genetic Investigations in Turkish Idiopathic Pancreatitis Patients Show Unique Characteristics., PMID:37823318
Substrate specificity of human chymotrypsin-like protease (CTRL) characterized by phage display-selected small-protein inhibitors., PMID:37604733
Clinical and Genetic Description of Hereditary Chronic Pancreatitis in Pakistani Children., PMID:37603299
Spectrum of PRSS1, SPINK1, CTRC, CFTR, and CPA1 Gene Variants in Chronic Pancreatitis Patients in Russia., PMID:37389024
Fecal Protein Profile in Eight Dogs Suffering from Acute Uncomplicated Diarrhea before and after Treatment., PMID:36977272
Comparative Genomic and Transcriptomic Analyses Reveal the Impacts of Genetic Admixture in Kazaks, Uyghurs, and Huis., PMID:36869755
Soluble and insoluble protein aggregates, endoplasmic reticulum stress, and vascular dysfunction in Alzheimer's disease and cardiovascular diseases., PMID:36823398
Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation., PMID:36797199
The Coexistence of TRPV6 Variants With Other Pancreatitis-Associated Genes Affects Pediatric-Onset Pancreatitis., PMID:36599151
Alterations in the pH of pancreatic juice are associated with chymotrypsin C inactivation and lithostathine precipitation in chronic pancreatitis patients: a proteomic approach., PMID:36572850
FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells., PMID:36515690
Different genotype and a liquid whey-supplemented diet influence the resilience of pigs through immune-modulation and anti-inflammatory response., PMID:36439344
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses., PMID:36395603
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma., PMID:36116415
Proteomic Analysis Identifies Three Reliable Biomarkers of Intestinal Inflammation in the Stools of Patients With Inflammatory Bowel Disease., PMID:36040453
Expanding ACMG variant classification guidelines into a general framework., PMID:35974416
Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis., PMID:35934298
Highly mutated monoclonal antibody 3F2 targets a conformational and strain-restricted epitope in human immunodeficiency virus gp41 with significant antibody-dependent cell cytotoxicity., PMID:35871426
Genotype-Phenotype Correlations in Asian Indian Children and Adolescents with Primary Hyperparathyroidism., PMID:35567607
Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms., PMID:35331647
Periodontal Disease Augments Cardiovascular Disease Risk Biomarkers in Rheumatoid Arthritis., PMID:35327515
A generic protocol for the affinity-purification of native macromolecular complexes from poxvirus-infected cells., PMID:35118428
Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis., PMID:34923708
Structure and function of the poxvirus transcription machinery., PMID:34861934
Multiplex Protein Biomarker Profiling in Patients with Familial Hypercholesterolemia., PMID:34680994
Structural basis of the complete poxvirus transcription initiation process., PMID:34556871
The Impacts of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis., PMID:34461303
Faecal proteome in clinically healthy dogs and cats: Findings in pooled faeces from 10 cats and 10 dogs., PMID:33981443
For research use only. Not for human or drug use.
