Catalog No.
AHJ98601
Biological activity
Measured by its ability to cleave carnosine (beta-Ala-L-His) in a two-step assay. The specific activity is >250 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Pro28-His507
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96KN2
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Carnosine dipeptidase 1, Glutamate carboxypeptidase-like protein 2, Beta-Ala-His dipeptidase, CNDP1, CN1, CNDP dipeptidase 1, Serum carnosinase, CPGL2
Integrating metabolomics and transcriptomics to analyze differences in muscle mass and flavor formation in Gayal and yellow cattle., PMID:40438416
Integrated transcriptomic and metabolomic analysis of goose epididymis reveals molecular markers associated with sperm mobility., PMID:40273680
Low Plasma Carnosinase-1 Activity in Patients with Left Ventricular Systolic Dysfunction: Implications for Carnosine Therapy in Heart Failure., PMID:40141250
CNDP1 Overexpression by Promoter Hypomethylation Predicts Poor Prognosis and Immunotherapy Response in Mucosal Melanoma., PMID:40133062
Why Bestatin Prefers Human Carnosinase 2 (CN2) to Human Carnosinase 1 (CN1)., PMID:39574306
Cefadroxil Targeting of SLC15A2/PEPT2 Protects From Colistin Nephrotoxicity., PMID:39522761
The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis., PMID:39489227
CNDP1 Suppresses the Malignant Behavior of Hepatoma Cell via Restricting PI3K-AKT-mTOR Activation., PMID:39229979
Assessing carnosinase 1 activity for diagnosing congenital disorders of glycosylation., PMID:39226631
Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC., PMID:38987361
State of the Art in the Development of Human Serum Carnosinase Inhibitors., PMID:38893364
Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma., PMID:38883336
Identification of brain-enriched proteins in CSF as biomarkers of relapsing remitting multiple sclerosis., PMID:38880880
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study., PMID:38757252
Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis., PMID:38626544
Capillary blood protein markers of posttraumatic headache in children after concussion., PMID:38457794
Exploring candidate biomarkers for rheumatoid arthritis through cardiovascular and cardiometabolic serum proteome profiling., PMID:38420123
A proteomic classifier panel for early screening of colorectal cancer: a case control study., PMID:38383428
Characteristics of changes in plasma proteome profiling after sleeve gastrectomy., PMID:38375199
Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells., PMID:38104097
Astragaloside IV Attenuates Programmed Death-Ligand 1-Mediated Immunosuppression during Liver Cancer Development via the miR-135b-5p/CNDP1 Axis., PMID:37894415
Exploratory mass spectrometry of cerebrospinal fluid from persons with autopsy-confirmed LATE-NC., PMID:37674727
[A preliminary discussion on carnosine dipeptidase 1 as a potential novel biomarker for the diagnostic and prognostic evaluation of hepatocellular carcinoma]., PMID:37400388
Carnosinase-1 Knock-Out Reduces Kidney Fibrosis in Type-1 Diabetic Mice on High Fat Diet., PMID:37372000
Recent Progress in Genetics and Epigenetics Research on Diabetic Nephropathy in Malaysia., PMID:37187702
Serum and urinary carnosinase-1 correlate with kidney function and inflammation., PMID:36319874
Genome-Wide Identification of Associations of Circulating Molecules With Spontaneous Coronary Artery Dissection and Aortic Aneurysm and Dissection., PMID:35571188
Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues., PMID:35141507
A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease., PMID:34946941
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control., PMID:34845204
Novel Relationship Between Plasmalogen Lipid Signatures and Carnosine in Humans., PMID:34328693
Identifi cation of the Underlying Genetic Factors of Skin Aging in a Korean Population Study., PMID:35349426
Proteomic Analysis of Serum Differentially Expressed Proteins Between Allergic Bronchopulmonary Aspergillosis and Asthma., PMID:33184749
Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration., PMID:32974084
Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBROb/Ob mice., PMID:32803273
Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose., PMID:32733966
A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice., PMID:32664451
Association of Proteins Modulating Immune Response and Insulin Clearance During Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus., PMID:32326243
Carnosinase-1 overexpression, but not aerobic exercise training, affects the development of diabetic nephropathy in BTBR ob/ob mice., PMID:32150446
Quantitative Comparative Proteomics Reveals Candidate Biomarkers for the Early Prediction of Gestational Diabetes Mellitus: A Preliminary Study., PMID:32111749
Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease., PMID:31950064
Carnosine and Kidney Diseases: What We Currently Know?, PMID:31362685
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications., PMID:31073745
Carnosine and Diabetic Nephropathy., PMID:30914013
Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy., PMID:30610469
Plasma proteome profiling of high-altitude polycythemia using TMT-based quantitative proteomics approach., PMID:30605725
Carnosine modulates the Sp1-Slc31a1/Ctr1 copper-sensing system and influences copper homeostasis in murine CNS-derived cells., PMID:30485136
Genetics, Genomics, and Precision Medicine in End-Stage Kidney Disease., PMID:30082052
Detection of carnosinase-1 in urine of healthy individuals and patients with type 2 diabetes: correlation with albuminuria and renal function., PMID:29961141
Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity., PMID:29922921
For research use only. Not for human or drug use.
