Catalog No.
AHK28401
Biological activity
When recombinant human TMIGD2/CD28H/IGPR1 (Cat #: AHK28401) is immobilized at 0.125 μg/mL, 100 μL/well, the concentration of recombinant human B7-H7 that produces 50% of the optimal binding response is approximately 0.07-0.35 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu23-Gly150
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96BF3
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IGPR-1, CD28H, CD28 homolog, Immunoglobulin and proline-rich receptor 1, TMIGD2, IGPR1, Transmembrane and immunoglobulin domain-containing protein 2
Mir-615-5p inhibits cervical cancer progression by targeting TMIGD2., PMID:39789663
MicroRNA-486-3p affects cisplatin resistance in high-grade serous ovarian cancer by regulating TMIGD2: An experimental study., PMID:39145009
Human endogenous retrovirus-H long terminal repeat-associating 2: an emerging immune checkpoint for cancer immunotherapy., PMID:38973642
The Importance of HHLA2 in Solid Tumors-A Review of the Literature., PMID:38786018
TOP CAR with TMIGD2 as a safe and effective costimulatory domain in CAR cells treating human solid tumors., PMID:38718110
Pharmacological suppression of HHLA2 glycosylation restores anti-tumor immunity in colorectal cancer., PMID:38522775
B7-H7: A potential target for cancer immunotherapy., PMID:37290327
TMIGD2 as a potential therapeutic target in glioma patients., PMID:37261362
Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategies., PMID:37069229
Peripheral blood mononuclear cell derived biomarker detection using eXplainable Artificial Intelligence (XAI) provides better diagnosis of breast cancer., PMID:37030103
HHLA2 immune-regulatory roles in cancer., PMID:37011487
An immune checkpoint-based signature predicts prognosis and chemotherapy response for patients with small cell lung cancer., PMID:36989973
Overexpression and Role of HHLA2, a Novel Immune Checkpoint, in Colorectal Cancer., PMID:36982953
Differentially Infiltrated Identification of Novel Diagnostic Biomarkers Associated with Immune Infiltration in Nasopharyngeal Carcinoma., PMID:36438903
Protocol for evaluating antitumor activity of KIR3DL3 blockade in an NK cell-based xenogeneic lung tumor model., PMID:36386885
Comprehensive characterization of costimulatory molecule gene for diagnosis, prognosis and recognition of immune microenvironment features in sepsis., PMID:36368641
Prognosis Analysis and Validation of Fatty Acid Metabolism-Related lncRNAs and Tumor Immune Microenvironment in Cervical Cancer., PMID:35942212
KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy., PMID:35933091
NK Cells Equipped With a Chimeric Antigen Receptor That Overcomes Inhibition by HLA Class I for Adoptive Transfer of CAR-NK Cells., PMID:35585985
Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma., PMID:35441736
Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy., PMID:35439678
Immune-related lincRNA pairs predict prognosis and therapeutic response in hepatocellular carcinoma., PMID:35277569
Expression of HHLA2, TMIGD2, and GITR in salivary gland adenoid cystic carcinoma and mucoepidermoid carcinoma., PMID:35226778
HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells., PMID:35175496
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target., PMID:34244312
Identification of an immune checkpoint gene signature that accurately predicts prognosis and immunotherapy response in endometrial carcinoma., PMID:34158412
NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway., PMID:33962630
KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1., PMID:33229411
CD28 gene polymorphisms and acute cellular rejection after liver transplantation., PMID:33097290
Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy., PMID:32978258
Prognostic value of immune checkpoint molecules in breast cancer., PMID:32602545
Iron Deprivation in Human T Cells Induces Nonproliferating Accessory Helper Cells., PMID:32284314
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling., PMID:32005952
Phenotypical and potential functional characteristics of different immune cells expressing CD28H/B7-H5 and their relationship with cancer prognosis., PMID:31901178
Overexpression of B7H5/CD28H is associated with worse survival in human gastric cancer., PMID:31883303
The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress., PMID:31341021
Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy., PMID:31108883
The Expression Patterns and Associated Clinical Parameters of Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 and Transmembrane and Immunoglobulin Domain Containing 2 in Oral Squamous Cell Carcinoma., PMID:31089395
Expanded peripheral CD4+CD28null T cells and its association with atherosclerotic changes in patients with end stage renal disease on hemodialysis., PMID:30853362
B7-H5/CD28H is a co-stimulatory pathway and correlates with improved prognosis in pancreatic ductal adenocarcinoma., PMID:30548441
CD8+CD28- T cells: not only age-related cells but a subset of regulatory T cells., PMID:29375130
The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3., PMID:28258693
IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function., PMID:27838321
The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account., PMID:27191544
Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis., PMID:26071192
A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2., PMID:25869386
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein., PMID:25549724
B7-H5 costimulates human T cells via CD28H., PMID:23784006
Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis., PMID:22419821
For research use only. Not for human or drug use.
