Catalog No.
AHN56801
Biological activity
Measured by its ability of the immobilized protein to support the adhesion of human acute T cell leukemia cells (Jurkat). When 5 x 10^4 cells per well are added to recombinant human SECTM1 (Cat #: AHN56801) coated plates, cell adhesion is enhanced in a dose dependent manner. The ED50 for this effect is 1.5-7.5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln29-Gly145
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WVN6
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SECTM1, K12, Secreted and transmembrane protein 1, Protein K-12
Development and Validation of Early Alert Model for Diabetes Mellitus-Tuberculosis Comorbidity., PMID:40284755
SECTM1 acts as an immune-related biomarker of poor prognosis and promotes cancer progression by modulating M2 macrophage polarization in esophageal squamous cell carcinoma., PMID:39944684
Deficiency of SECTM1 impairs corneal wound healing in aging., PMID:38887148
SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFβ1/Smad signaling pathway., PMID:38164182
Comprehensive Analyses Revealed Eight Immune Related Signatures Correlated With Aberrant Methylations as Prognosis and Diagnosis Biomarkers for Kidney Renal Papillary Cell Carcinoma., PMID:37455213
Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells., PMID:37277920
SECTM1-based CAR T cells enriched with CD7-low/negative subsets exhibit efficacy in CD7-positive malignancies., PMID:36848638
The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., PMID:32075873
Molecular and genomic characterization of a novel equine molluscum contagiosum-like virus., PMID:31922947
Corneal Epithelial Stem Cells Repopulate the Donor Area within 1 Year from Limbus Removal for Limbal Autograft., PMID:27665215
Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia., PMID:27064756
Tex19 and Sectm1 concordant molecular phylogenies support co-evolution of both eutherian-specific genes., PMID:26459560
Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7., PMID:24211252
Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells., PMID:24170316
SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway., PMID:24157461
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation., PMID:22184754
The T/NK cell co-stimulatory molecule SECTM1 is an IFN "early response gene" that is negatively regulated by LPS in human monocytic cells., PMID:21749909
Transcriptional profiling of Francisella tularensis infected peripheral blood mononuclear cells: a predictive tool for tularemia., PMID:18680519
Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma., PMID:15742156
Characterization of putative stem cell phenotype in human limbal epithelia., PMID:15153612
Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2., PMID:14769151
Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretroviral therapy., PMID:11861829
Identification of CD7 as a cognate of the human K12 (SECTM1) protein., PMID:10652336
Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms., PMID:9480746
For research use only. Not for human or drug use.
