Catalog No.
AHJ28501
Biological activity
Measured by its ability to stimulate human T cell proliferation. The ED50 for this effect is 0.75-4.5 µg/mL. Optimal dilutions should be determined by each laboratory for each application.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Tyr16-Leu155
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TDQ1
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IREM1, Immunoglobulin superfamily member 13, NK inhibitory receptor, CD300 antigen-like family member F, CD300F, CD300LF, CLM-1, IGSF13, NKIR, IREM-1, Immune receptor expressed on myeloid cells 1, CMRF35-like molecule 1, CD300f, IgSF13, CLM1
Phosphatidylserine-binding receptor, CD300f, on macrophages mediates host invasion of pathogenic and non-pathogenic rickettsiae., PMID:40310290
[Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]., PMID:39307798
Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models., PMID:38600251
Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3., PMID:38517345
Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury., PMID:37798310
CD300f signalling induces inhibitory human monocytes/macrophages., PMID:37302321
Myricetin served as antagonist for negatively regulate MRGPRX2 mediated pseudo-allergic reactions through CD300f/SHP1/SHP2 phosphorylation., PMID:36958208
Clarithromycin-treated chronic spontaneous urticaria with the negative regulation of FcεRΙ and MRGPRX2 activation via CD300f., PMID:35853276
Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2-induced pseudo-allergic reaction., PMID:35312106
CD300a and CD300f molecules regulate the function of leukocytes., PMID:33548578
Targeting CD300f to enhance hematopoietic stem cell transplantation in acute myeloid leukemia., PMID:32215656
CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness., PMID:32152116
A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection., PMID:31548687
Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation., PMID:31501529
Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain., PMID:31476319
CD300f is a potential therapeutic target for the treatment of food allergy., PMID:31471969
CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation., PMID:31338922
Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils., PMID:30479367
CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions., PMID:29345367
Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections., PMID:29221685
Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis., PMID:29051512
CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production., PMID:28725048
Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment., PMID:28655892
Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation., PMID:28414292
Astrocytic Expression of the Immunoreceptor CD300f Protects Hippocampal Neurons from Amyloid-β Oligomer Toxicity In Vitro., PMID:28155597
Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation., PMID:28073916
A key requirement for CD300f in innate immune responses of eosinophils in colitis., PMID:27118491
Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice., PMID:26768664
CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype., PMID:26259611
CD300f associates with IL-4 receptor α and amplifies IL-4-induced immune cell responses., PMID:26124135
Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation., PMID:25673319
[An inhibitory receptor LMIR3/CD300f recognizes ceramide]., PMID:24505937
p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression., PMID:24477292
Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation., PMID:24035150
CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis., PMID:23820751
The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide., PMID:23123064
Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors., PMID:22291008
Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K., PMID:22288587
CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines., PMID:22043923
Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury., PMID:21951326
Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis., PMID:21865548
CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1., PMID:21536801
CD300 heterocomplexes, a new and family-restricted mechanism for myeloid cell signaling regulation., PMID:20959446
The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase., PMID:17202342
For research use only. Not for human or drug use.
