Catalog No.
AHK80601
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human GPC2/Glypican-2 (Cat #: AHK80601) at 4 µg/mL (100 µL/well) can bind recombinant human Midkine with a linear range of 4-200 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Pro18-Ser553
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N158
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glypican-2, GPC2
Structural Features of Glypicans and their Impact on Wnt Signaling in Cancer., PMID:40416340
A model of basement membrane-related regulators for prediction of prognoses in esophageal cancer and verification in vitro., PMID:40234833
Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma., PMID:39908652
A novel basement membrane-related gene signature for predicting prognosis of HNSCC., PMID:39833042
CAR T-cells for pediatric solid tumors: where to go from here?, PMID:39317919
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma., PMID:39164224
rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors., PMID:39043602
Identification and validation of basement membrane-related genes predicting prognosis and immune infiltration associated with bladder cancer., PMID:39029072
GPC2 promotes prostate cancer progression via MDK-mediated activation of PI3K/AKT signaling pathway., PMID:39014225
Enhanced anti-tumor activity mediated by combination chimeric antigen receptor T cells targeting GD2 and GPC2 in high-risk neuroblastoma., PMID:38904586
Basement membrane-associated gene expression as a predictor of survival in oral cancer., PMID:38877482
Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells., PMID:38864848
Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts., PMID:38786073
Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum., PMID:38562841
GPC2 as a diagnostic and prognostic marker regulated progression of colorectal cancer., PMID:38220478
BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma., PMID:37688570
Comprehensive in silico analysis of glycosylphosphatidylinositol- anchored protein (GPI-AP) related genes expression profiles in human normal and cancer tissues., PMID:37609818
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer., PMID:37410084
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior., PMID:36944188
Association between GPC2 polymorphisms and neuroblastoma risk in Chinese children., PMID:36920409
Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated., PMID:36800341
Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma., PMID:36631162
GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies., PMID:36460335
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors., PMID:36167467
An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma., PMID:35852863
Genome-Wide Association Study of Egg-Laying Traits and Egg Quality in LingKun Chickens., PMID:35795788
GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer., PMID:35345673
Development of Glypican-2 Targeting Single-Domain Antibody CAR T Cells for Neuroblastoma., PMID:35157288
Fine-tuning CARs for best performance., PMID:35016025
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity., PMID:34971569
Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization., PMID:34465595
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope., PMID:34337560
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice., PMID:34195677
Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3., PMID:33992682
Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma., PMID:33902495
Prognostic value of Glypican family genes in early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy and possible mechanisms., PMID:33302876
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities., PMID:32620753
Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., PMID:32019583
Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology., PMID:31951107
Glypicans as Cancer Therapeutic Targets., PMID:30352677
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma., PMID:28898695
Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma., PMID:28739923
Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis., PMID:28440309
Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination., PMID:26722758
Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors., PMID:25935541
Regulation of Zn and Fe transporters by the GPC1 gene during early wheat monocarpic senescence., PMID:25524236
Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers., PMID:23251904
Divergent functions of orthologous NAC transcription factors in wheat and rice., PMID:22278768
Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice., PMID:21111798
Effect of glypican-1 gene on the pulp cells during the reparative dentine process., PMID:20515442
For research use only. Not for human or drug use.
