Catalog No.
AHN57001
Biological activity
Measured by its ability to enhance neurite outgrowth of dissociated E13 chick embryonic dorsalroot ganglia (DRG) neurons. Able to significantly enhance neurite outgrowth when immobilized at 3-12 µg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln42-Ser676
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N0W4
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HNLX, NLGN4X, Neuroligin-4, X-linked, KIAA1260, NLGN4, Neuroligin X
Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function., PMID:40032531
Analyses of Human Genetic Data to Identify Clinically Relevant Domains of Neuroligins., PMID:39766868
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation., PMID:38902533
Gene Signature Associated with Nervous System in an Experimental Radiation- and Estrogen-Induced Breast Cancer Model., PMID:38137332
Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury., PMID:38091407
NLGN4X TCR transgenic T cells to treat gliomas., PMID:37715782
The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain., PMID:36747195
Of Humans and Gerbils- Independent Diversification of Neuroligin-4 Into X- and Y-Specific Genes in Primates and Rodents., PMID:35431802
Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction., PMID:34690695
Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size., PMID:34542148
RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma., PMID:34403115
Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus., PMID:33721831
Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder: Clinical, cytogenetic, and molecular characterization., PMID:33369065
An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons., PMID:33268543
Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms., PMID:32873342
Neuroligins and Neurodevelopmental Disorders: X-Linked Genetics., PMID:32848696
Understanding the Landscape of X-linked Variants Causing Intellectual Disability in Females Through Extreme X Chromosome Inactivation Skewing., PMID:32564284
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y., PMID:32243781
Elevated Plasma X-Linked Neuroligin 4 Expression Is Associated with Autism Spectrum Disorder., PMID:32155636
Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells., PMID:32100075
Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents., PMID:32011705
Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y., PMID:31852540
Sex identification in horses (Equus caballus) based on the gene pair NLGN4X/NLGN4Y., PMID:31318073
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons., PMID:31257103
Y chromosome gene copy number and lack of autism phenotype in a male with an isodicentric Y chromosome and absent NLGN4Y expression., PMID:31161682
5-ALA/SFC Attenuated Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats., PMID:31141180
Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease., PMID:29622757
Diagnostic efficacy and new variants in isolated and complex autism spectrum disorder using molecular karyotyping., PMID:29564645
Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder., PMID:29428674
Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survival., PMID:29244827
Male homosexuality and maternal immune responsivity to the Y-linked protein NLGN4Y., PMID:29229842
Binding of mycotoxins to proteins involved in neuronal plasticity: a combined in silico/wet investigation., PMID:29123130
Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation., PMID:28948087
Expanding the genetic spectrum of ANOS1 mutations in patients with congenital hypogonadotropic hypogonadism., PMID:28122887
Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort., PMID:27782075
Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression., PMID:27626693
Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder., PMID:26901793
GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability., PMID:26055424
Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking., PMID:25778475
Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses., PMID:25675530
Ochratoxin A as possible factor trigging autism and its male prevalence via epigenetic mechanism., PMID:25597866
Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features., PMID:25558953
Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients., PMID:24570023
Gene expression signatures of primary and metastatic uterine leiomyosarcoma., PMID:24485798
Screening of NLGN3 and NLGN4X genes in Thai children with autism spectrum disorder., PMID:24362370
A genome-wide survey of transgenerational genetic effects in autism., PMID:24204716
Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence., PMID:23907288
Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism., PMID:23851596
Expression and significance of neuroligins in myenteric cells of Cajal in Hirschsprung's disease., PMID:23840625
Xp22.3 interstitial deletion: a recognizable chromosomal abnormality encompassing VCX3A and STS genes in a patient with X-linked ichthyosis and mental retardation., PMID:23791652
For research use only. Not for human or drug use.
