Catalog No.
AHN56901
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human CBLN2 (Cat #: AHN56901) is coated at 5 μg/mL, biotinylated recombinantrat NRXN-1 beta binds with an apparent KD <1.5 nM.
Measured by its ability to enhance neurite outgrowth of rat embryonic cortical neurons (E16-E18). Recombinant human CBLN2 (Cat #: AHN56901), immobilized at 3-30 μg/mL, is able to significantly enhance neurite outgrowth.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg50-Leu224
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IUK8
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CBLN2, Cerebellin-2
Histone H3 lysine 9 tri-methylation is associated with pterygium., PMID:40033254
CBLN2 overexpression inhibits colorectal cancer progression and improves immunotherapy responses., PMID:39577217
Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants., PMID:37944084
Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-κB/HIF-1α/Twist1 pathway., PMID:37355224
Cerebellin-neurexin complexes instructing synapse properties., PMID:37209532
Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner., PMID:36205393
Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain., PMID:34685624
Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis., PMID:34599306
Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors., PMID:34158618
GluD1 is a signal transduction device disguised as an ionotropic receptor., PMID:34135511
CBLN2 rs2217560 was Associated with Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus., PMID:30539924
Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs., PMID:30287486
Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin., PMID:29784783
The genomic landscape of small cell carcinoma of the esophagus., PMID:29728688
Spinal injection of newly identified cerebellin-1 and cerebellin-2 peptides induce mechanical hypersensitivity in mice., PMID:29705514
Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain., PMID:29691328
Cerebellins are differentially expressed in selective subsets of neurons throughout the brain., PMID:28714144
Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats., PMID:27805868
Genome-wide association study of meat quality traits in chicken., PMID:26400276
The genetics of pulmonary arterial hypertension., PMID:24951767
The genetic basis of pulmonary arterial hypertension., PMID:24442418
Genetics and the molecular pathogenesis of pulmonary arterial hypertension., PMID:24078385
Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord., PMID:23853053
GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis., PMID:23651021
Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism., PMID:22948383
Cerebellins: capstones to bridge the synaptic cleft., PMID:22288876
The Cbln family of proteins interact with multiple signaling pathways., PMID:22220752
Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes., PMID:22191730
Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice., PMID:22117778
Localization of cerebellin-2 in late embryonic chicken brain: implications for a role in synapse formation and for brain evolution., PMID:21456003
Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions., PMID:21410790
Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons., PMID:21356198
Identification of cerebellin2 in chick and its preferential expression by subsets of developing sensory neurons and their targets in the dorsal horn., PMID:20506477
Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis., PMID:19212655
Precerebellin-related genes and precerebellin 1 peptide in endocrine glands of the rat - pattern of their expression., PMID:19082514
Expression of precerebellins in cultured rat calvaria osteoblast-like cells., PMID:18813864
Cbln and C1q family proteins: new transneuronal cytokines., PMID:18278437
Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons., PMID:18001291
Characterization of a transneuronal cytokine family Cbln--regulation of secretion by heteromeric assembly., PMID:17331201
Distinct expression of Cbln family mRNAs in developing and adult mouse brains., PMID:16930405
Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells., PMID:15702230
Genomic structure and mapping of precerebellin and a precerebellin-related gene., PMID:7877445
For research use only. Not for human or drug use.
