Catalog No.
AHJ18001
Biological activity
Measured by its binding ability in a functional ELISA. In a 100 μL reaction mixture containing rhIFNLR1/IL-28RA (Cat #: AHJ18001) at 1 μg/mL and rhIL-28A dilutions at 1-1000 ng/mL, the concentration of rhIL-28A that produces 50% of the optimal binding response is found to be approximately 40-200 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg21-Ala228
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IU57
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytokine receptor class-II member 12, IFN-lambda-R1, CRF2-12, IFNLR1, IL28RA, IL-28 receptor subunit alpha, Cytokine receptor family 2 member 12, Interleukin-28 receptor subunit alpha, IL-28RA, Interferon lambda receptor 1, IFN-lambda receptor 1, IL-28R-alpha, LICR2, Likely interleukin or cytokine receptor 2
Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2., PMID:40155377
IFNλ1 is a STING-dependent mediator of DNA damage and induces immune activation in lung cancer., PMID:40012911
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis., PMID:39953266
Function of Interferon Lambda Receptor 1 Variants in Stem Cell-Derived Hepatocytes with Abrogated Endogenous IFNLR1., PMID:39929255
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering., PMID:39827213
Identification of Novel Proteins Mediating Causal Association Between Smoking and Essential Hypertension: A Mendelian Randomization Study., PMID:39604029
Antiviral Effect of Melatonin on Caco-2 Cell Organoid Culture: Trick or Treat?, PMID:39595940
Context-specific anti-inflammatory roles of type III interferon signaling in the lung in nonviral injuries., PMID:39455422
Expression and function of interferon lambda receptor 1 variants., PMID:39435588
Interferon lambda signaling in neutrophils enhances the pathogenesis of Bordetella pertussis infection., PMID:39302155
Cell-intrinsic regulation of phagocyte function by interferon lambda during pulmonary viral, bacterial super-infection., PMID:39178311
Molecular characteristics of rhesus macaque interferon-lambda receptor 1 (mmuIFNLR1): Sequence identity, distribution and alteration after simian-human immunodeficiency virus infection in the skin and buccal mucosa., PMID:39103005
Type III interferon drives pathogenicity to Staphylococcus aureus via the airway epithelium., PMID:38934617
Structure-function of type I and III interferons., PMID:38608537
Can inflammatory plasma proteins predict Long COVID or Fatigue severity after SARS-CoV-2 infection?, PMID:38508399
Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology., PMID:38426749
Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium., PMID:38136633
Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes., PMID:38070830
Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies., PMID:37834019
Understanding the immune profile of sudden infant death syndrome - proteomic perspectives., PMID:37792385
Deletion of Interferon Lambda Receptor Elucidates Susceptibility to the Murine Model of Biliary Atresia., PMID:37725010
Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation., PMID:37725008
Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1., PMID:37499093
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling., PMID:37440406
PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells., PMID:37146414
Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling., PMID:36992341
Kinetics of interferon-λ and receptor expression in response to in vitro respiratory viral infection., PMID:36950890
Suicide-Related Single Nucleotide Polymorphisms, rs4918918 and rs10903034: Association with Dementia in Older Adults., PMID:36421848
Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity., PMID:36385011
The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection., PMID:36379255
Respiratory Syncytial Virus Protects Bystander Cells against Influenza A Virus Infection by Triggering Secretion of Type I and Type III Interferons., PMID:36326278
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas., PMID:36206767
Interferon Signaling-Dependent Contribution of Glycolysis to Rubella Virus Infection., PMID:35631058
Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner., PMID:35471083
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium., PMID:35137688
Transcriptome analysis of the early stage ifnlr1-mutant zebrafish indicates the immune response to auditory dysfunction., PMID:34968768
Type III Interferons: Emerging Roles in Autoimmunity., PMID:34899712
Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza., PMID:34899695
Identification of Shared and Asian-Specific Loci for Systemic Lupus Erythematosus and Evidence for Roles of Type III Interferon Signaling and Lysosomal Function in the Disease: A Multi-Ancestral Genome-Wide Association Study., PMID:34783190
Interferon Lambda Regulates Cellular and Humoral Immunity in Pristane-Induced Lupus., PMID:34769174
Runs of homozygosity analysis reveals population characteristics of yellow-feathered chickens using re-sequencing data., PMID:34747677
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2., PMID:34723226
B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus., PMID:34706932
Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection., PMID:34705554
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota., PMID:34520306
Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects., PMID:34497603
IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease., PMID:34436524
Treatment induced clearance of hepatitis E viruses by interferon-lambda in liver-humanized mice., PMID:34392598
Downregulated expression of IL‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma., PMID:34195850
Role of IFNLR1 gene in PRRSV infection of PAM cells., PMID:34056880
For research use only. Not for human or drug use.
