Catalog No.
AHN38901
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human BTN2A1 (Cat #: AHN38901) is immobilized at 1 µg/mL (100 µL/well), the concentration of recombinant human DC‑SIGN/CD209 that produces 50% of the optimal binding response is approximately 0.1-0.5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln29-Ala248
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7KYR7
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BTN2A1, BT2.1, BTF1, Butyrophilin subfamily 2 member A1
Identifying novel protein biomarkers with cross-psychiatric disorders effects and potential intervention targets: Evidence from proteomic-Mendelian randomization., PMID:40334965
Mapping the extracellular molecular architecture of the pAg-signaling complex with α-Butyrophilin antibodies., PMID:40204806
A Brief Molecular History of Vγ9Vδ2 TCR-Mediated Phosphoantigen Sensing., PMID:40181561
Investigation of structural and dynamic properties of the Butyrophilin BTN3A1/BTN2A1 cytoplasmic complex by 19F solution NMR., PMID:40079188
Unusual Partners: γδ-TCR-Based T Cell Therapy in Combination with Oncolytic Virus Treatment for Diffuse Midline Gliomas., PMID:40076788
Large-Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain., PMID:40048323
Genome-wide Mendelian randomization mapping the influence of plasma proteome on major depressive disorder., PMID:39892755
Epstein-Barr Virus BRRF1 Induces Butyrophilin 2A1 in Nasopharyngeal Carcinoma NPC43 Cells via the IL-22/JAK3-STAT3 Pathway., PMID:39769218
BTN2A1: A Novel Target to Boost Tumor Killing Capacity of Human γδ T Cells., PMID:39475356
Exploring potential therapeutic targets for asthma: a proteome-wide Mendelian randomization analysis., PMID:39472987
Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis., PMID:39351539
BTN2A1 targeting reprograms M2-like macrophages and TAMs via SYK and MAPK signaling., PMID:39325623
Targeting BTN2A1 Enhances Vγ9Vδ2 T-Cell Effector Functions and Triggers Tumor Cell Pyroptosis., PMID:39302336
Potential of gamma/delta T cells for solid tumor immunotherapy., PMID:39253082
Phosphoantigen recognition by Vγ9Vδ2 T cells., PMID:39148158
A Ménage à trois: NLRC5, immunity, and metabolism., PMID:39035010
Cuproptosis-related gene DLAT is a biomarker of the prognosis and immune microenvironment of gastric cancer and affects the invasion and migration of cells., PMID:39031012
Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1., PMID:39029338
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers., PMID:39014161
Nominating novel proteins for anxiety via integrating human brain proteomes and genome-wide association study., PMID:38697224
Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)., PMID:38636565
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing., PMID:38374404
γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids., PMID:38090581
Anti-PD1 does not improve pyroptosis induced by γδ T cells but promotes tumor regression in a pleural mesothelioma mouse model., PMID:38077396
A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing., PMID:37993425
Analysis of Butyrophilin-Mediated Activation of γδ T Cells from Human Spleen., PMID:37991420
Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety., PMID:37961556
B7H3-targeting chimeric antigen receptor modification enhances antitumor effect of Vγ9Vδ2 T cells in glioblastoma., PMID:37770968
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells., PMID:37674084
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection., PMID:37648854
Frameshift mutations of immunomodulatory BTN2A1, BTN2A2, and BTNL3 genes in colon cancers., PMID:37634314
Low plasma PD-L1 levels, early tumor onset and absence of peritoneal carcinomatosis improve prognosis of women with advanced high-grade serous ovarian cancer., PMID:37179293
Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1., PMID:37171180
Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1., PMID:36995939
Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells., PMID:36824912
Prognostic role of soluble PD-1 and BTN2A1 in overweight melanoma patients treated with nivolumab or pembrolizumab: finding the missing links in the symbiotic immune-metabolic interplay., PMID:36818688
Genome-wide identification and skin expression of immunoglobulin superfamily in discus fish (Symphysodon aequifasciatus) reveal common genes associated with vertebrate lactation., PMID:36775217
Hypoxia-adapted Multiple Myeloma Stem Cells Resist γδ-T-Cell-mediated Killing by Modulating the Mevalonate Pathway., PMID:36697063
The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers., PMID:36685546
EBV latent membrane protein 1 augments γδ T cell cytotoxicity against nasopharyngeal carcinoma by induction of butyrophilin molecules., PMID:36632221
Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab., PMID:36543375
Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes., PMID:36509785
Can circulating PD-1, PD-L1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels enhance prognostic power of CA125 in patients with advanced high-grade serous ovarian cancer?, PMID:36212445
Cutting Edge: Bispecific γδ T Cell Engager Containing Heterodimeric BTN2A1 and BTN3A1 Promotes Targeted Activation of Vγ9Vδ2+ T Cells in the Presence of Costimulation by CD28 or NKG2D., PMID:36096643
Role of Vγ9vδ2 T lymphocytes in infectious diseases., PMID:35924233
γδ T Cells in the Tumor Microenvironment-Interactions With Other Immune Cells., PMID:35880177
BTN3A Targeting Vγ9Vδ2 T Cells Antimicrobial Activity Against Coxiella burnetii-Infected Cells., PMID:35833118
Butyrophilins: γδ T Cell Receptor Ligands, Immunomodulators and More., PMID:35371078
Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex., PMID:35081362
Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds., PMID:34815357
For research use only. Not for human or drug use.
