Catalog No.
AMG78901
Biological activity
Immobilized Mouse GAS6 (Cat #: AMG78901) at 5μg/mL (100μL/well) on the plate. Dose response curve for human AXL with the EC50 of 3.1ng/mL.
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Val28-Pro674
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q61592
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AXLLG, Growth arrest-specific protein 6, AXL receptor tyrosine kinase ligand, GAS6, GAS-6,
Electrochemical immunosensing for rapid glaucoma disease diagnosis through simultaneous determination of SPP1 and GAS6 proteins in ocular fluids., PMID:40494269
GAS6/AXL signaling promotes M2 microglia efferocytosis to alleviate neuroinflammation in sepsis-associated encephalopathy., PMID:40480981
Modulation of microglial phagocytosis via the GAS6-MERTK pathway regulates pathological angiogenesis in the mouse oxygen-induced retinopathy model., PMID:40456730
Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin-A., PMID:40454659
Exploring the Link Between Vitamin K and Depression: A Systematic Review., PMID:40428819
Single-Cell RNA-Seq Reveals Aging-Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury., PMID:40374315
AXL and SRC in clear cell renal cell carcinoma: absence of mutations, rare alternative splicing events, but association of protein expression with poor prognosis., PMID:40260977
NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance., PMID:40217343
Dimerization of GAS2 mediates crosslinking of microtubules and F-actin., PMID:40169809
Does serum Gas6 level change in active uveitis?, PMID:40151682
Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions., PMID:40090391
Sex-specific molecular hallmarks point to increased atherogenesis susceptibility in male senescence-accelerated mice., PMID:40049367
AXL kinase inhibitor exhibits antitumor activity by inducing apoptotic cell death in triple-negative breast cancer cells., PMID:40044045
Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl., PMID:40040711
Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX3CR1+ synovial lining macrophage barrier., PMID:40038808
Gas6 induces AIM to suppress acute lung injury in mice by inhibiting NLRP3 inflammasome activation and inducing autophagy., PMID:40034700
Novel anti-inflammatory compounds that alleviate experimental autoimmune encephalomyelitis., PMID:40023067
Fatty acid uptake activates an AXL-CAV1-β-catenin axis to drive melanoma progression., PMID:40015991
Transcriptomic Insights into Gas6-Induced Placental Dysfunction: Gene Targets for Preeclampsia Therapy., PMID:39996749
Effects of Chlorella protothecoides-derived polydeoxyribonucleotides on skin regeneration and wound healing., PMID:39994014
AXL-Mediated Drug Resistance in ALK-Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts., PMID:39904499
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis., PMID:39897049
Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications., PMID:39896467
New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis., PMID:39892997
Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis., PMID:39878883
Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients., PMID:39861478
Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis., PMID:39844194
Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarisation., PMID:39788632
Mangiferin Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the GAS6/Axl Signaling Pathway., PMID:39780746
Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice., PMID:39774471
Lower Circulating Gas6 Levels Are Associated with Bulbar Phenotype and Faster Disease Progression in Amyotrophic Lateral Sclerosis Patients., PMID:39762711
Bone metastasis in endocrine-related cancer: unravelling invasion and destruction., PMID:39699130
Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease., PMID:39684449
Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis., PMID:39673059
High-Throughput Screening of an FDA-Approved Compound Library Reveals a Novel GAS6 Receptor Agonist for Therapeutic Intervention in Septic Myocardial and microvascular Injury via Modulation of Danger-Associated Molecular Patterns., PMID:39664568
Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway., PMID:39628480
Nano-Biomechanical Investigation of Phosphatidylserine-Mediated Ebola Viral Attachment via Human Gas6 and Axl., PMID:39599815
Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation., PMID:39566608
AXL/GAS6 signaling governs differentiation of tumor-associated macrophages in breast cancer., PMID:39510154
CD73 promotes non-small cell lung cancer metastasis by regulating Axl signaling independent of GAS6., PMID:39423241
The AXL inhibitor bemcentinib overcomes microenvironment-mediated resistance to pioglitazone in acute myeloid leukemia., PMID:39325663
GAS6 as a potential target to alleviate neuroinflammation during Japanese encephalitis in mouse models., PMID:39300526
Gas6/Axl signaling promotes hematoma resolution and motivates protective microglial responses after intracerebral hemorrhage in mice., PMID:39288830
The protective role of Mertk in JEV-induced encephalitis by maintaining the integrity of blood-brain barrier., PMID:39277738
Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain., PMID:39270646
Extracellular vesicles containing GAS6 protect the liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via MerTK-ERK-COX2 signaling., PMID:39256347
Learning from serum markers reflecting endothelial activation: longitudinal data in childhood-onset systemic lupus erythematosus., PMID:39242108
ATF3 coordinates the survival and proliferation of cardiac macrophages and protects against ischemia-reperfusion injury., PMID:39195894
Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours., PMID:39179860
Understanding the Molecular Landscape of Endometriosis: A Bioinformatics Approach to Uncover Signaling Pathways and Hub Genes., PMID:39108650
For research use only. Not for human or drug use.
