Catalog No.
AHH45201
Biological activity
Immobilized recombinant human MICA (Cat #: AHH45201) at 2 μg/mL (100 μL/well) can bind NKG2D with a linear range of 0.61-14.3 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Gln308
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q29983
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MICA, MIC-A, MHC class I polypeptide-related sequence A, PERB11.1
Comprehensive Mendelian randomization analysis and experimental investigation identifies the causal relationship between immunity and kidney stone disease., PMID:40498118
Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor., PMID:40458406
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment., PMID:40442619
Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia., PMID:40440957
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference., PMID:40437880
AFM-Based Monitoring of Enzymatic Activity of Individual Molecules of Cytochrome CYP102A1., PMID:40422042
NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells., PMID:40421025
Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial., PMID:40389374
Identification of the Novel MICA*002:01:30 Allele in a Haematopoietic Stem Cell Donor From India., PMID:40387404
Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington's disease: a [18F]SynVesT-1 study., PMID:40381377
Macrophage-derived pro-inflammatory cytokines augment the cytotoxicity of cytokine-induced killer cells by strengthening the NKG2D pathway in multiple myeloma., PMID:40369131
Plasma proteins and different onset subtype of COPD: Proteome-wide Mendelian randomization study and co-localization analyses., PMID:40355193
EPS inhibitor treatment of Salmonella impacts evolution without selecting for resistance to biofilm inhibition., PMID:40328762
The Novel MICA*010:01:15 Allele in an Individual From West Bengal, India., PMID:40320791
Ophthalmological manifestations and plasma markers of inflammation in Ebola survivors in post-treatment era., PMID:40301432
"Virtual crossmatch reveals donor-specific MICA antibodies in antibody mediated rejection: First established Indian case"., PMID:40280498
CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity., PMID:40274283
γδT cells, a key subset of T cell for cancer immunotherapy., PMID:40226616
Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway., PMID:40213545
Allele and Haplotype Frequencies of 17 HLA-Related Loci in Shenzhen Chinese Population by Next-Generation Sequencing., PMID:40193066
The reverse sequence of Aβ amyloid self-triggers isolated nano-fibers and oligomers in lipid environment., PMID:40122490
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease., PMID:40085416
Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency., PMID:40061947
BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells., PMID:40029697
Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis., PMID:40021214
CAR-NK cells with dual targeting of PD-L1 and MICA/B in lung cancer tumor models., PMID:40000974
An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding., PMID:39999840
Plasma proteins and herpes simplex virus infection: a proteome-wide Mendelian randomization study., PMID:39992613
Sesamin induces cell cycle arrest and upregulation of NKG2D ligands in MG‑63 cells and increases susceptibility to NK cell cytotoxicity., PMID:39991723
Effective charge of high-generation PAMAM dendrimers in the adsorbed state., PMID:39923691
Changing the amyloid nucleation process using small molecules and substrates: a way to build two-dimensional materials., PMID:39902864
Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights., PMID:39902633
NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome., PMID:39885466
The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases., PMID:39866909
Role of the androgen receptor in melanoma aggressiveness., PMID:39837817
Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli., PMID:39836471
Sex differences in the time trends of sepsis biomarkers following polytrauma., PMID:39827304
Evolution of anti-MICA antibodies after imlifidase infusion for a high immunological risk kidney transplantation., PMID:39826255
Using the Radial Distribution Function to Analyze Atomic Force Microscopy Images of Colloidal Systems., PMID:39796067
AFM observation of protein translocation mediated by one unit of SecYEG-SecA complex., PMID:39779699
Melittin-Induced Structural Transformations in DMPG and DMPS Lipid Membranes: A Langmuir Monolayer and AFM Study., PMID:39770152
Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS., PMID:39762745
Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39762078
A disintegrin and metallopeptidase domain (ADAM) 12, ADAM 17 mRNA and ADAM10 protein hold potential as biomarkers for detection of early gastric cancer., PMID:39755747
Recognition of Self and Viral Ligands by NK Cell Receptors., PMID:39748148
Sticky organisms create underwater biological adhesives driven by interactions between EGF- and GlcNAc- containing polysaccharides., PMID:39747843
Self-Assembly Behavior of Zein on Two Different Substrates Visualized by Atomic Force Microscopy., PMID:39745119
Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates., PMID:39729164
Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab., PMID:39699928
Three-Year Overall Survival With Nivolumab Plus Relatlimab in Advanced Melanoma From RELATIVITY-047., PMID:39671533
For research use only. Not for human or drug use.
