Catalog No.
AHH45101
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human NKG2D/CD314 Fc Chimera is immobilized at 0.125 μg/mL, 100 μL/well, the concentration of recombinant human MICB (Cat #: AHH45101) that produces 50% of the optimal binding response is approximately 80-400 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala23-Thr308
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q29980
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MIC-B, MHC class I polypeptide-related sequence B, MICB, PERB11.2
Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk., PMID:40514331
Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells., PMID:40455858
Systematic Mendelian randomization of the human plasma proteome to identify therapeutic targets linking aging and frailty to perioperative delirium., PMID:40451486
Macrophage-derived pro-inflammatory cytokines augment the cytotoxicity of cytokine-induced killer cells by strengthening the NKG2D pathway in multiple myeloma., PMID:40369131
Plasma proteins and different onset subtype of COPD: Proteome-wide Mendelian randomization study and co-localization analyses., PMID:40355193
Ophthalmological manifestations and plasma markers of inflammation in Ebola survivors in post-treatment era., PMID:40301432
CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity., PMID:40274283
γδT cells, a key subset of T cell for cancer immunotherapy., PMID:40226616
Genetically druggable targets for MAPK-activated colorectal cancer by a two-sample mendelian randomization analysis., PMID:40210889
Mendelian randomization analysis of the causal relationship between plasma proteins and childhood asthma., PMID:40193678
Allele and Haplotype Frequencies of 17 HLA-Related Loci in Shenzhen Chinese Population by Next-Generation Sequencing., PMID:40193066
The clinical potential of PDL-1 pathway and some related micro-RNAs as promising diagnostic markers for breast cancer., PMID:40108523
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease., PMID:40085416
An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding., PMID:39999840
Plasma proteins and herpes simplex virus infection: a proteome-wide Mendelian randomization study., PMID:39992613
Sesamin induces cell cycle arrest and upregulation of NKG2D ligands in MG‑63 cells and increases susceptibility to NK cell cytotoxicity., PMID:39991723
Bidirectional Mendelian Randomization identifies plasma proteins associated with urticaria risk., PMID:39961865
Transcriptome-wide alternative splicing and transcript-level differential expression analysis of post-mortem Lewy body dementia brains., PMID:39924259
Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights., PMID:39902633
The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases., PMID:39866909
Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS., PMID:39762745
Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39762078
Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets., PMID:39676862
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial., PMID:39661372
Identification of oxidative stress-related biomarkers in uterine leiomyoma: a transcriptome-combined Mendelian randomization analysis., PMID:39640883
[The effect of c-Myc on regulating the immune-related ligands in Y subtype small cell lung cancer through histone deacetylase 1]., PMID:39622733
The MICA deletion across different populations., PMID:39571451
A mechanism of human cytomegalovirus for establishing latency through inhibition of HCMV UL16 expression by hcmv-miR-US33-5p., PMID:39557271
Genomics-driven integrative analysis highlights immune-related plasma proteins for psychiatric disorders., PMID:39491680
Distributions of MICA and MICB Alleles Typed by Amplicon-Based Next-Generation Sequencing in South Koreans., PMID:39470005
Causal associations of MICB, CTSA, and MMP9 proteins with oral cancer: Mendelian randomization study., PMID:39465349
Causal relationships between three plasma proteins and non-alcoholic fatty liver disease, mediated by Epstein-Barr virus EA-D antibody levels: a mendelian randomization study., PMID:39463412
[Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric cancer cells through down-regulation of major histocompatibility complex class I chain-related gene B (MICB) expression]., PMID:39442988
MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells., PMID:39379424
Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP data., PMID:39283896
A novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39211152
MICB*002:06, a novel exonic variant of MICB (MHC class I chain-related gene B)., PMID:39132702
The immunomodulatory effects of cannabidiol on Hsp70-activated NK cells and tumor target cells., PMID:39126837
Inhibition of MICA and MICB shedding enhances memory-like NK-cell-mediated cytotoxicity against multiple myeloma., PMID:39106432
Decoding the genetic landscape of juvenile dermatomyositis: insights from phosphorylation-associated single nucleotide polymorphisms., PMID:39085621
Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis., PMID:39010723
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification., PMID:38992170
The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation., PMID:38953028
The impact of MICB mismatches in unrelated haematopoietic stem cell transplantation., PMID:38932717
Characterisation of novel MICB alleles by next generation sequencing: MICB*055 and MICB*005:15., PMID:38923355
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
CTLA4 genetic variants associated with urothelial bladder cancer susceptibility., PMID:38879411
Proteasome inhibitors FHND6091 enhance the ability of NK cells to kill tumor cells through multiple mechanisms., PMID:38849039
MICB Genetic Variants and Its Protein Soluble Level Are Associated with the Risk of Chronic GvHD and CMV Infection after Allogeneic HSCT., PMID:38847554
A multi-ethnic reference panel to impute HLA classical and non-classical class I alleles in admixed samples: Testing imputation accuracy in an admixed sample from Brazil., PMID:38837862
For research use only. Not for human or drug use.
