Catalog No.
AHH28901
Biological activity
Measured by its ability to inhibit anti-CD3 antibody induced IL-2 or IFN-gamma secretion by human T cells. The ED50 for this effect 1-7.5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu21-Ser101
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16553
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SCA-2, TSA-1, 9804, Retinoic acid-induced gene E protein, TSA1, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, SCA2, RIGE, LY6E, RIG-E
Identification and immunoassay of biomarkers associated with T cell exhaustion in systemic lupus erythematosus., PMID:40207215
Induction of LY6E regulates interleukin-1β production, potentially contributing to the immunopathogenesis of systemic lupus erythematosus., PMID:40114200
Altered LY6E and TRIM6 expression in PBMCs correlated with HBsAg clearance and response to Peg-IFN-α treatment in HBeAg-negative chronic hepatitis B patients., PMID:40089754
PLSCR1 suppresses SARS-CoV-2 infection by downregulating cell surface ACE2., PMID:39945535
Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils., PMID:39833171
Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion., PMID:39487896
Exploring Molecular Drivers of PARPi Resistance in BRCA1-Deficient Ovarian Cancer: The Role of LY6E and Immunomodulation., PMID:39408764
Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection., PMID:39313785
Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formation., PMID:39287391
Study of LY9 as a potential biomarker for prognosis and prediction of immunotherapy efficacy in lung adenocarcinoma., PMID:39193519
Type I interferon gene expression signature as a marker to predict response to cyclophosphamide based treatment in proliferative lupus nephritis., PMID:39033304
Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes., PMID:38918127
The antiviral state of the cell: lessons from SARS-CoV-2., PMID:38795501
Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencing., PMID:38560173
Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID., PMID:38522030
Role of long non-coding RNA DLY6E in regulating TMUV infection., PMID:38438020
Identification and verification of inflammatory biomarkers for primary Sjögren's syndrome., PMID:38376769
Single-cell analysis with childhood and adult systemic lupus erythematosus., PMID:38347676
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing., PMID:38299418
Interferon-stimulated neutrophils as a predictor of immunotherapy response., PMID:38181798
N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA., PMID:38169284
LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression., PMID:38114778
Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages., PMID:38047075
Increased expression of SCARF genes favoring SARS-CoV-2 infection in key target organs in CKD., PMID:38046008
Cytosolic nucleic acid sensing and mitochondrial transcriptomic changes as early triggers of metabolic disease in db/db mice., PMID:37979047
Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry., PMID:37676001
Identification of fibroblast-related genes based on single-cell and machine learning to predict the prognosis and endocrine metabolism of pancreatic cancer., PMID:37588985
LY6E is a pan-coronavirus restriction factor in the respiratory tract., PMID:37443277
Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population., PMID:37340842
Risk prediction for dermatomyositis-associated hepatocellular carcinoma., PMID:37259059
A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response., PMID:37250795
Epigenetic and Tumor Microenvironment for Prognosis of Patients with Gastric Cancer., PMID:37238607
High expression of LY6E is an independent prognostic factor of colorectal cancer patients., PMID:36866762
LY6E protects mice from pathogenic effects of murine coronavirus and SARS-CoV-2., PMID:36747632
Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma., PMID:36607476
IL1RN and PRRX1 as a Prognostic Biomarker Correlated with Immune Infiltrates in Colorectal Cancer: Evidence from Bioinformatic Analysis., PMID:36483329
Development of T-cell engagers selective for cells co-expressing two antigens., PMID:36206404
Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats., PMID:36195733
Interferon-alpha regulates expression of lncRNA MALAT1 and interferon-stimulated genes, as well as chemokine production, in primary Sjögren's syndrome., PMID:36189916
LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood-brain barrier., PMID:36165190
Glucocorticoids mediate transcriptome-wide alternative polyadenylation: Potential mechanistic and clinical implications., PMID:36128656
Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder., PMID:36077244
Genomic and Transcriptomic Analyses of NF1-Mutant Melanoma Identify Potential Targeted Approach for Treatment., PMID:35988589
Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus., PMID:35967341
Coronavirus disease 2019 and the placenta: A literature review., PMID:35872511
The structural and functional divergence of a neglected three-finger toxin subfamily in lethal elapids., PMID:35830808
Association between interferon-I producing plasmacytoid dendritic cells and thrombotic antiphospholipid syndrome., PMID:35612283
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection., PMID:35580180
Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection., PMID:35468127
LY6S, a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance., PMID:35440514
For research use only. Not for human or drug use.
