Catalog No.
AHH28801
Biological activity
Measured by its ability to induce IL-6 secretion by mouse embryonic fibroblast cells (NIH‑3T3). The ED50 for this effect is 0.4‑2 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
IL17A [Gly24-Ala155] & IL17F [Arg31-Gln163]
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16552 & Q96PD4
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A,IL17F, Interleukin-17F, IL-17F, Cytokine ML-1
LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells., PMID:40410820
Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation., PMID:40127522
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders., PMID:39875232
Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8+ T cells to demote the antitumor immunity., PMID:37605139
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function., PMID:37580108
IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes., PMID:37115755
Brodalumab: Efficacy, safety, and survival in mid-term (52 weeks) on real clinical practice in Andalucia, Spain., PMID:36495585
Inhibiting IL-17A and IL-17F in Rheumatic Disease: Therapeutics Help to Elucidate Disease Mechanisms., PMID:35861937
The Yin and Yang of IL-17 in Systemic Sclerosis., PMID:35603223
Interleukin-17 promotes proliferation, migration, and invasion of trophoblasts via regulating PPAR-γ/RXR-α/Wnt signaling., PMID:35258399
Divergent functions of IL-17-family cytokines in DSS colitis: Insights from a naturally-occurring human mutation in IL-17F., PMID:34587561
Self-assembled chitosan nanoparticles for intranasal delivery of recombinant protein interleukin-17 receptor C (IL-17RC): preparation and evaluation in asthma mice., PMID:34180764
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression., PMID:32719138
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling., PMID:32187518
Immunological Variables Associated With Clinical and Endoscopic Response to Vedolizumab in Patients With Inflammatory Bowel Diseases., PMID:32100016
IL-17 Signaling in the Tumor Microenvironment., PMID:32060887
Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation., PMID:31175175
HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers., PMID:30840880
Population pharmacokinetics of brodalumab in patients with moderate to severe plaque psoriasis., PMID:30661290
Expression of IL-17F is associated with non-pathogenic Th17 cells., PMID:29959474
The human IL-17A/F heterodimer regulates psoriasis-associated genes through IκBζ., PMID:29938836
Association between serum interleukin-17A and clinical response to tofacitinib and etanercept in moderate to severe psoriasis., PMID:29748971
Dataset on characterization of recombinant interleukin-23α, IL-12p40 and IL-23 complex protein, which activates JAK-STAT signaling pathway in chicken cell lines using immunocytochemical staining., PMID:29541669
The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties., PMID:28827714
Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency., PMID:27930337
A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells., PMID:27594509
Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type., PMID:27589729
Brief Report: Arthritis in KRN T Cell Receptor-Transgenic Mice Does Not Require Interleukin-17 or Th17 Cells., PMID:26882006
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis., PMID:25918342
Molecular cloning, characterization and mRNA expression of duck interleukin-17F., PMID:25769677
Two novel gain-of-function mutations of STAT1 responsible for chronic mucocutaneous candidiasis disease: impaired production of IL-17A and IL-22, and the presence of anti-IL-17F autoantibody., PMID:25288569
Interleukin (IL)-17A, F and AF in inflammation: a study in collagen-induced arthritis and rheumatoid arthritis., PMID:24813051
Characterization of IL-22 and antimicrobial peptide production in mice protected against pulmonary Cryptococcus neoformans infection., PMID:24760968
Interleukin-17A in lipid metabolism and atherosclerosis., PMID:24508995
Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis., PMID:24504806
Identification of a soluble isoform of human IL-17RA generated by alternative splicing., PMID:24084331
Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma., PMID:23801634
Regulation of IL-17 family members by adrenal hormones during experimental sepsis in mice., PMID:23499051
Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1., PMID:22037550
Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice., PMID:21949019
Measuring autoantibodies against IL-17F and IL-22 in autoimmune polyendocrine syndrome type I by radioligand binding assay using fusion proteins., PMID:21535082
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity., PMID:21350122
IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis., PMID:20231694
IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen., PMID:19357249
Expression of interleukin-17RC protein in normal human tissues., PMID:18928529
The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex., PMID:18684971
IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice., PMID:18056371
An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment., PMID:18025225
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses., PMID:17452998
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells., PMID:17355969
For research use only. Not for human or drug use.
