Catalog No.
AHH19601
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of human squamous cell carcinoma cells (FaDu). When 5 x 10^4 cells per well are added to rhCHI3L2 (Cat #: AHH19601) coated plates for 30 minutes at 37 ℃, cell adhesion is enhanced in a dose dependent manner with typical ED50 range of 0.7-2.8 μg/mL. Opitimal dilutions should be determined by each laboratory for each application.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Tyr27-Leu390
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15782
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHI3L2, YKL-39, Chondrocyte protein 39, Chitinase-3-like protein 2
Genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals., PMID:40093208
Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study., PMID:39624674
New insights into the role of the CHI3L2 protein in invasive ductal breast carcinoma., PMID:39557919
Dual role of exosomal circCMTM3 derived from GSCs in impeding degradation and promoting phosphorylation of STAT5A to facilitate vasculogenic mimicry formation in glioblastoma., PMID:39310105
A Predictive Noninvasive Single-Nucleotide Variation-Based Biomarker Signature for Resectable Pancreatic Cancer: Protocol for a Prospective Validation Study., PMID:38635586
Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics., PMID:38303405
Association of Genetic Markers with the Risk of Early-Onset Breast Cancer in Kazakh Women., PMID:38254997
Chitinases as a potential diagnostic and prognostic biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis., PMID:38194198
Analysis, validation, and discussion of key genes in placenta of patients with gestational diabetes mellitus., PMID:37873933
Synovial Fluid Proteomics From Serial Aspirations of ACL-Injured Knees Identifies Candidate Biomarkers., PMID:37191559
M2 macrophage marker CHI3L2 could serve as a potential prognostic and immunological biomarker in glioma by integrated single-cell and bulk RNA-Seq analysis., PMID:37147894
Differential Gene Expression and DNA Methylation in the Risk of Depression in LOAD Patients., PMID:36421693
A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer's disease brains., PMID:36136224
Chitinase 3-Like 2., PMID:35913110
IL-2, IL-6 and chitinase 3-like 2 might predict early relapse activity in multiple sclerosis., PMID:35759479
Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration., PMID:35409356
An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes., PMID:34818986
CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis., PMID:34497102
Comprehensive Analysis of CD163 as a Prognostic Biomarker and Associated with Immune Infiltration in Glioblastoma Multiforme., PMID:34395626
Cerebrospinal Fluid Chitinases as Biomarkers for Amyotrophic Lateral Sclerosis., PMID:34359293
Modic changes are associated with activation of intense inflammatory and host defense response pathways - molecular insights from proteomic analysis of human intervertebral discs., PMID:34303868
Circular RNA circ-CHI3L1.2 modulates cisplatin resistance of osteosarcoma cells via the miR-340-5p/LPAATβ axis., PMID:34164774
Monocyte-Derived Macrophages Contribute to Chitinase Dysregulation in Amyotrophic Lateral Sclerosis: A Pilot Study., PMID:34054686
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression., PMID:34017124
CHI3L2 Is a Novel Prognostic Biomarker and Correlated With Immune Infiltrates in Gliomas., PMID:33937022
Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients., PMID:33924468
Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival., PMID:33828170
Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines., PMID:32787775
CHI3L2 Expression Levels Are Correlated with AIF1, PECAM1, and CALB1 in the Brains of Alzheimer's Disease Patients., PMID:32705525
CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis., PMID:32666680
CSF chitinase 3-like-1 association with disability of primary progressive MS., PMID:32611760
Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease., PMID:32066474
YKL-39 as a Potential New Target for Anti-Angiogenic Therapy in Cancer., PMID:32038607
Time-Course Transcriptome Analysis of Gingiva-Derived Mesenchymal Stem Cells Reveals That Fusobacterium nucleatum Triggers Oncogene Expression in the Process of Cell Differentiation., PMID:31993418
M2 Macrophage Marker Chitinase 3-Like 2 (CHI3L2) Associates With Progression of Conventional Renal Cell Carcinoma., PMID:31810965
CSF chitinase proteins in amyotrophic lateral sclerosis., PMID:31123140
Identification and Validation of a Biomarker Signature in Patients With Resectable Pancreatic Cancer via Genome-Wide Screening for Functional Genetic Variants., PMID:30942874
Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis., PMID:30797944
Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy., PMID:29728799
Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis., PMID:29331073
CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients., PMID:28989002
Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster., PMID:28404605
Cerebrospinal fluid chitinase-3-like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis., PMID:26872061
Role of chitinase-like proteins in cancer., PMID:26733160
RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response., PMID:25826113
Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis., PMID:25698171
Structural and thermodynamic insights into chitooligosaccharide binding to human cartilage chitinase 3-like protein 2 (CHI3L2 or YKL-39)., PMID:25477513
Identifying causal variants at loci with multiple signals of association., PMID:25104515
Determination of chitinases family during osteoclastogenesis., PMID:24440516
Human cartilage chitinase 3-like protein 2: cloning, expression, and production of polyclonal and monoclonal antibodies for osteoarthritis detection and identification of potential binding partners., PMID:24111862
For research use only. Not for human or drug use.
