Catalog No.
AHH07801
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human EphA7 (Cat #: AHH07801) is coated at 2 μg/mL (100 μL/well), the concentration of biotinylayed rhEphrin-A4 that produces 50% of the optimal binding response is found to be approximately 1.5‑6 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Val555
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15375
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EHK3, hEK11, Ephrin type-A receptor 7, HEK11, EHK-3, EPH homology kinase 3, EK11, EPHA7, EPH-like kinase 11
Ephrin-A5 or EphA7 stimulation is anti-proliferative for human rhabdomyosarcoma in vitro., PMID:40426233
Calcifying pseudoneoplasm of the neuraxis progressing to G5/PDGFRA subgroup glioblastoma in a United States Army veteran with a history of head trauma and germline POT1 and EPHB2 mutations: illustrative case., PMID:40388884
tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer's disease via the EphA7-ERK1/2-p70S6K signaling pathway., PMID:40375351
Regulatory role of neuronal guidance proteins in spinal cord injury., PMID:40364635
Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1/DNMT1 and PI3K/AKT axes and improves the response to multiple therapies in cervical cancer., PMID:40258813
Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development., PMID:40145984
Altered TP53, CDKN2A, ATM, EPHA7, POT1, CHEK1, GRIN2A, and EGFR Predict Shorter Survival in Penile Squamous Cell Carcinoma., PMID:39694330
Intra-BLA alteration of interneurons' modulation of activity in rats, reveals a dissociation between effects on anxiety symptoms and extinction learning., PMID:39512628
EphA-Mediated Regulation of Stomatin Expression in Prostate Cancer Cells., PMID:39377541
The Role of Biomarkers in the Early Diagnosis of Gastric Cancer: A Study on CCR5, CCL5, PDGF, and EphA7., PMID:39329983
Membrane Proteome-Wide Screening of Autoantibodies in CIDP Using Human Cell Microarray Technology., PMID:38484217
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4., PMID:37993804
Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts., PMID:37978056
Meta-analysis of microarray data to determine gene indicators involved in the cisplatin resistance in ovarian cancer., PMID:37937323
In-silico and structure-based assessment to evaluate pathogenicity of missense mutations associated with non-small cell lung cancer identified in the Eph-ephrin class of proteins., PMID:37813626
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma., PMID:37738252
Ten-m3 plays a role in the formation of thalamostriatal projections., PMID:37700636
Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells., PMID:37569713
Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells., PMID:37277920
May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?, PMID:36613532
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney., PMID:36266461
Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma., PMID:36037142
Patients deriving long-term benefit from immune checkpoint inhibitors demonstrate conserved patterns of site-specific mutations., PMID:35798829
The identification and validation of EphA7 hypermethylation, a novel biomarker, in cervical cancer., PMID:35681118
The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Doxorubicin and Topotecan Resistant Ovarian Cancer Cell Lines., PMID:35628654
Epigenetic switch controls social actions., PMID:35390284
c-Met and EPHA7 Receptor Tyrosine Kinases Are Related to Prognosis in Clear Cell Renal Cell Carcinoma: Focusing on the Association with Myoferlin Expression., PMID:35205843
EPHA2, EPHA4, and EPHA7 Expression in Triple-Negative Breast Cancer., PMID:35204461
The role of EphA7 in different tumors., PMID:35112312
Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region., PMID:35103233
Transcriptome-guided resolution of tumor microenvironment interactions in pheochromocytoma and paraganglioma subtypes., PMID:35088383
ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder., PMID:35081333
The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines., PMID:35008952
Artesunate-induced Cellular Effects Are Mediated by Specific EPH Receptors and Ephrin Ligands in Breast Carcinoma Cells., PMID:34949656
A Novel Missense Variant of HOXD13 Caused Atypical Synpolydactyly by Impairing the Downstream Gene Expression and Literature Review for Genotype-Phenotype Correlations., PMID:34777468
MicroRNA-146b-5p/EPHA7 axis regulates cell invasion, metastasis, proliferation, and temozolomide-induced chemoresistance via regulation of IRAK4/TRAF6/NF-κB signaling pathway in aggressive pituitary adenoma., PMID:34746996
Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons., PMID:34546353
Machine learning identifies molecular regulators and therapeutics for targeting SARS-CoV2-induced cytokine release., PMID:34486798
Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers., PMID:34399808
Clinical genomic profiling to identify actionable alterations for very early relapsed triple-negative breast cancer patients in the Chinese population., PMID:34396843
microRNA-196b promotes esophageal squamous cell carcinogenesis and chemoradioresistance by inhibiting EPHA7, thereby restoring EPHA2 activity., PMID:34354862
The Expression Profile and Prognostic Values of EPHA Family Members in Breast Cancer., PMID:34221956
Crystal structure of clinically reported mutations Gly656Arg, Gly656Glu and Asp751His identified in the kinase domain of EphA7., PMID:34186436
EPHA7 haploinsufficiency is associated with a neurodevelopmental disorder., PMID:34176129
Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in Chemotherapy., PMID:33977106
Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension., PMID:33906900
EPHA7 mutation as a predictive biomarker for immune checkpoint inhibitors in multiple cancers., PMID:33526018
Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma., PMID:33439936
EphA7 isoforms differentially regulate cortical dendrite development., PMID:33275600
Identification of adhesion-associated DNA methylation patterns in the peripheral nervous system., PMID:33273976
For research use only. Not for human or drug use.
