Catalog No.
AHG93101
Biological activity
Immobilized human GPNMB (Cat #: AHG93101) at 1 μg/mL (100 μL/well) can bind anti-GPNMB Rabbit pAb with a linear range of 0.976-116.5 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Lys23-Pro486
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14956
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NMB, Hematopoietic growth factor inducible neurokinin-1 type, HGFIN, GPNMB, Transmembrane glycoprotein NMB
bTRM Control of Murine Cytomegalovirus CNS Reactivation., PMID:40508083
Macrophages Lacking TSC2 have mTORC1-dependent GPNMB Augmentation Ameliorating Cardiac Ischemia-Reperfusion Injury., PMID:40501569
GPNMB Expression Identifies FLCN-Associated Eosinophilic Renal Tumors With Heterogeneous Clinicopathologic Spectrum and Gene Expression Profiles., PMID:40470587
CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures., PMID:40435316
Mgat4b-mediated selective N-glycosylation regulates melanocyte development and melanoma progression., PMID:40424122
Glycoprotein nonmetastatic melanoma protein b immunohistochemistry can be a useful ancillary tool to diagnose subependymal giant cell astrocytoma., PMID:40419674
Unlocking diagnostic potential: A retrospective analysis of GPNMB immunohistochemistry in nearly 1000 surgical pathology specimens., PMID:40389121
Evaluation of 3,606 renal cell tumors for TFE3 rearrangements and TFEB alterations via fluorescence in situ hybridization, next generation sequencing, and GPNMB immunohistochemistry., PMID:40381702
Overexpression of LINC00672 promotes autophagy in Alzheimer's disease by upregulating GPNMB., PMID:40367036
Expression cloning of cell surface receptors for the CpG oligodeoxynucleotide/CXCL14 complex., PMID:40345012
Skeletal muscle biomarkers of amyotrophic lateral sclerosis: a large-scale, multi-cohort proteomic study., PMID:40313273
[Clinicopathological and molecular characteristics of renal cell carcinomas with TFEB gene amplification]., PMID:40302582
Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens., PMID:40278930
Identification of pivotal genes and regulatory networks associated with SAH based on multi-omics analysis and machine learning., PMID:40274967
Genome-wide association studies of the fatty acid composition of Korean native chicken breast meat., PMID:40264524
Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB., PMID:40251684
A proteogenomic tool uncovers protein markers for human microglial states., PMID:40236015
GPNMB Suppresses Inflammation and Extracellular Matrix Degradation in Nucleus Pulposus Cells by Inhibiting Pro-Inflammatory Cytokine Production and Activation of the NF-κB Signaling Pathway., PMID:40234039
A Mendelian randomization study on association of alpha-synuclein and GPNMB with Parkinson's disease risk and progression., PMID:40214956
Characterisation of macrophages in healthy and diseased livers in mice: identification of necrotic lesion-associated macrophages., PMID:40212045
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses., PMID:40200337
Modeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion., PMID:40197748
TFE3-rearranged ossifying fibromyxoid tumors are uniquely negative for glycoprotein non-metastatic melanoma protein B: A study of 13 TFE3-rearranged mesenchymal tumors., PMID:40189028
GPNMB regulates the differentiation and transformation of monocyte-derived macrophages during MASLD., PMID:40186908
Examination of the histogenesis of epithelial cysts in angiomyolipoma with epithelial cysts (AMLEC) using GPNMB and TSC2 immunostains., PMID:40180055
Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease., PMID:40176187
Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery., PMID:40164598
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury., PMID:40117216
Acquired resistance to immune checkpoint therapy is caused by glycoprotein non-metastatic melanoma protein B signal cascade., PMID:40114009
Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction., PMID:40088037
GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophages., PMID:40038549
ELF5 gene promotes milk lipid synthesis in goat mammary epithelial cells by transcriptomic analysis., PMID:40015575
Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease., PMID:40008429
GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles., PMID:39992792
Secretomes of Gingival Fibroblasts From Periodontally Diseased Tissues: A Proteomic Analysis., PMID:39988729
The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration., PMID:39983908
Glycoprotein nonmetastatic melanoma protein B is regulated by hepatic peroxisome proliferator-activated receptor γ in liver steatosis., PMID:39971219
CSF GPNMB in Parkinson's disease: A potential association with age and microglial activation., PMID:39957200
Patterns of expression and prognostic implication of glycoprotein nonmetastatic protein B (GPNMB) expression in sentinel lymph nodes of melanoma patients., PMID:39951029
The glycoprotein GPNMB protects against oxidative stress through enhanced PI3K/AKT signaling in epidermal keratinocytes., PMID:39947468
MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB., PMID:39849576
GPNMB expression differentiates subependymal giant cell astrocytoma from other mimickers., PMID:39837150
Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis., PMID:39819676
Integrated transcriptomics and proteomics analysis of the impact of iodine‑125 in hepatocellular carcinoma., PMID:39791207
[MED15-TFE3 renal cell carcinoma: a clinicopathological and molecular analysis]., PMID:39762166
Nuclear receptor PPARγ targets GPNMB to promote oligodendrocyte development and remyelination., PMID:39756479
Integrated lipidomics and RNA-seq reveal prognostic biomarkers in well-differentiated and dedifferentiated retroperitoneal liposarcoma., PMID:39696292
GPNMB attenuates neuroinflammation and improves ischemic stroke via modulation of PI3K/Akt and p38 MAPK signaling pathways., PMID:39643105
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis., PMID:39642243
Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study., PMID:39624674
For research use only. Not for human or drug use.
