Catalog No.
AHG25901
Biological activity
Measured by its ability to transfer GalNAc from UDP-GalNAc to peptide EA2. The specific activity is >350 pmol/min/μg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Lys52-Gln571
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q10471
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
pp-GaNTase 2, GALNT2, Polypeptide GalNAc transferase 2, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2, GalNAc-T2, Polypeptide N-acetylgalactosaminyltransferase 2, Protein-UDP acetylgalactosaminyltransferase 2
Exploring the combined roles of GALNT1 and GALNT2 in hepatocellular carcinoma malignancy and EGFR modulation., PMID:40095226
Glycosylation Pathways Targeted by Deregulated miRNAs in Autism Spectrum Disorder., PMID:39859496
GalNT2-mediated O-glycosylation affects pancreas development and function in mice., PMID:39613794
Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and Macrovascular Complications of Type 2 Diabetes., PMID:38791405
GALNT2 expression is associated with glucose control and serum metabolites in patients with type 2 diabetes., PMID:38627282
Integrative single-cell analysis of LUAD: elucidating immune cell dynamics and prognostic modeling based on exhausted CD8+ T cells., PMID:38596689
GALNT2 targeted by miR-139-5p promotes proliferation of clear cell renal cell carcinoma via inhibition of LATS2 activation., PMID:38478152
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression., PMID:37993881
Quantitative mapping of the in vivo O-GalNAc glycoproteome in mouse tissues identifies GalNAc-T2 O-glycosites in metabolic disorder., PMID:37862385
Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids., PMID:37834292
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis., PMID:37597090
The sub-molecular characterization identification for cervical cancer., PMID:37484385
Application of genetic risk score for in-stent restenosis of second- and third-generation drug-eluting stents in geriatric patients., PMID:37468836
RNA-Sequencing Characterization of lncRNA and mRNA Functions in Septic Pig Liver Injury., PMID:37107704
GALNT2 sustains glioma stem cells by promoting CD44 expression., PMID:37000153
Integrated bioinformatics analyses identifying key transcriptomes correlated with prognosis and immune infiltrations in lung squamous cell carcinoma., PMID:36879671
Leveraging Genetics to Address the Role of GALNT2 on Atherogenic Dyslipidemia., PMID:36861373
O-Glycosylating Enzyme GALNT2 Predicts Worse Prognosis in Cervical Cancer., PMID:36110252
The O-glycosylating enzyme GALNT2 acts as an oncogenic driver in non-small cell lung cancer., PMID:36058918
GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level., PMID:35885984
A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis., PMID:35304331
N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion., PMID:35279766
Role of GALNT2 on Insulin Sensitivity, Lipid Metabolism and Fat Homeostasis., PMID:35055114
Polypeptide N-acetylgalactosaminyltransferase-Associated Phenotypes in Mammals., PMID:34576978
GALNT2/14 overexpression correlate with prognosis and methylation: potential therapeutic targets for lung adenocarcinoma., PMID:33964375
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma., PMID:33785338
Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving High-Density Lipoprotein Cholesterol., PMID:33296900
Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2., PMID:33152927
GALNT2 regulates ANGPTL3 cleavage in cells and in vivo of mice., PMID:32999434
TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy., PMID:32699192
Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function., PMID:32293671
Quantile-dependent expressivity of postprandial lipemia., PMID:32101585
Survival-related risk score of lung adenocarcinoma identified by weight gene co-expression network analysis., PMID:31611953
Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing., PMID:31499127
Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells., PMID:31455323
Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis., PMID:31076460
Generalizability and applicability of results obtained from populations of European descent regarding the effect direction and size of HDL-C level-associated genetic variants to the Hungarian general and Roma populations., PMID:30468910
Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines., PMID:30327431
Paeoniflorin regulates GALNT2-ANGPTL3-LPL pathway to attenuate dyslipidemia in mice., PMID:30096295
Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans., PMID:29987113
TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation., PMID:29593093
ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice., PMID:29104012
HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics., PMID:29103089
Altered expression of different GalNAc‑transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer., PMID:29039611
Novel regulators of plasma lipid levels., PMID:28333714
GALNT2 effect on HDL-cholesterol and triglycerides levels in humans: Evidence of pleiotropy?, PMID:28153384
[Genetic determination of dyslipidemia - What tell us the results of genome-wide association studies?]., PMID:28128572
Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders., PMID:28097321
Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3., PMID:28025493
Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents., PMID:27508872
For research use only. Not for human or drug use.
