Catalog No.
AHG02501
Biological activity
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >15 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln36-Ser655
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q04756
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HGF activator, Hepatocyte growth factor activator, HGFA, HGFAC
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment., PMID:40442619
Sex differences in proteomics of cardiovascular disease - Results from the Yale-CMD registry., PMID:40224648
Combined Therapy Targeting MET and Pro-HGF Activation Shows Significant Therapeutic Effect Against Liver Metastasis of CRPC., PMID:40076928
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
An exploratory SWATH plasma proteomics analysis of phyllodes tumor- a type of female breast tumor., PMID:39933222
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury., PMID:39515667
Identification of potential novel targets for treating inflammatory bowel disease using Mendelian randomization analysis., PMID:39414629
ADH4-a potential prognostic marker for hepatocellular carcinoma with possible immune-related implications., PMID:39090641
Integrating plasma proteomics with genome-wide association data to identify novel drug targets for inflammatory bowel disease., PMID:39009667
Clinical characterization and proteomic profiling of lean nonalcoholic fatty liver disease., PMID:38034020
Genetic vulnerability to Crohn's disease reveals a spatially resolved epithelial restitution program., PMID:37878672
Integrated analysis of the lncRNA-associated ceRNA network in Alzheimer's disease., PMID:37187245
Molecular mechanisms investigation for liver metastasis of colorectal cancer by combined bioinformatic gene expression profile analysis., PMID:36868002
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses., PMID:36857861
The effect of hepatocyte growth factor on intestinal adaption in an experimental model of short bowel syndrome., PMID:36631569
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis., PMID:36413406
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage., PMID:36028175
Alterations in the kallikrein-kinin system predict death after heart transplant., PMID:35986069
Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption., PMID:35661789
Genome-wide identification of copy number variation and association with fat deposition in thin and fat-tailed sheep breeds., PMID:35614300
Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans., PMID:34547768
[Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer]., PMID:34238413
Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B., PMID:33096475
COVID-19-Related Coagulopathy-Is Transferrin a Missing Link?, PMID:32751741
TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue-bound HGF., PMID:32539223
Bioinformatics analysis of key biomarkers and potential molecular mechanisms in hepatocellular carcinoma induced by hepatitis B virus., PMID:32443377
Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes., PMID:31511937
Proteome of normal human perilymph and perilymph from people with disabling vertigo., PMID:31185063
HGFAC expression decreased in liver cancer and its low expression correlated with DNA hypermethylation and poor prognosis., PMID:30635948
Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair., PMID:30388869
Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas., PMID:29987920
Differential expression of genes encoding proteins of the HGF/MET system in insulinomas., PMID:26435753
Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA)., PMID:25998175
Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells., PMID:22877752
Hepatic gene expression and plasma albumin concentration related to outcome after attenuation of a congenital portosystemic shunt in dogs., PMID:21641243
For research use only. Not for human or drug use.
